Abstract: A system and apparatus are provided for use in determining a spacing of a gap between a first flange and a second flange connected by at least one bolt using an integrated sensor. The sensor may include a plurality of electric coils for generating an AC magnetic field for causing a magnetic material to produce a dynamic mechanical response as a result of a change in the spacing of the first and second flanges. A holder for the sensor may be provided, and may be adapted for positioning between the joined parts or the associated flanges, and further may be adapted to attach to a bolt connecting the parts. Related methods are also disclosed, including for estimating a retained load on a gasket or seal associated with the first and second flanges.

Abstract: A system and apparatus are provided for use in determining a spacing of a gap between a first flange and a second flange connected by at least one bolt using an integrated sensor. The sensor may include a plurality of electric coils for generating an AC magnetic field for causing a magnetic material to produce a dynamic mechanical response as a result of a change in the spacing of the first and second flanges. A holder for the sensor may be provided, and may be adapted for positioning between the joined parts or the associated flanges, and further may be adapted to attach to a bolt connecting the parts. Related methods include estimating a retained load on a gasket or seal associated with the first and second flanges.

Abstract: A system is for determining a viscoelastic property of a flexible seal, such as for use in connection with a vessel having a junction formed between first and second rigid parts that serve to compress the seal in use. A magnetic material is coupled to the flexible seal, and a generator such as an electric coil is provided for generating a magnetic field for causing the magnetic material to output a signal representative of a dynamic mechanical response of the magnetic material. A sensor senses the signal. An analyzer may be provided for analyzing the signal to determine the viscoelastic property of the object. Flexible seals with one or more embedded permanent magnets are disclosed, as are a method and apparatus for manufacturing such a seal using superconductive levitation to position a magnetic material, such as a permanent magnet, in a mold cavity during injection of a molding material.

Abstract: A system is for determining a viscoelastic property of a flexible seal, such as for use in connection with a vessel having a junction formed between first and second rigid parts that serve to compress the seal in use. An oscillator including a magnetic material is coupled to the flexible seal, such as in a cantilevered manner with an integral part embedded in the flexible seal and projecting outwardly therefrom. A generator such as an electric coil is provided for generating a magnetic field for causing the magnetic material to output a signal representative of a dynamic mechanical response of the magnetic material. A sensor senses the signal. An analyzer may be provided for analyzing the signal to determine the viscoelastic property of the object. Flexible seals with one or more embedded permanent magnets are disclosed, as are related methods.

Abstract: A system is for determining a viscoelastic property of a flexible seal, such as for use in connection with a vessel having a junction formed between first and second rigid parts that serve to compress the seal in use. A magnetic material is coupled to the flexible seal, and a generator such as an electric coil is provided for generating a magnetic field for causing the magnetic material to output a signal representative of a dynamic mechanical response of the magnetic material. A sensor senses the signal. An analyzer may be provided for analyzing the signal to determine the viscoelastic property of the object. Flexible seals with one or more embedded permanent magnets are disclosed, as are a method and apparatus for manufacturing such a seal using superconductive levitation to position a magnetic material, such as a permanent magnet, in a mold cavity during injection of a molding material.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A vessel receives and agitates a fluid using an internal fluid-agitating element driven by an external motive device. In one aspect, the vessel is a bag including a first receiver for receiving and holding a fluid-agitating element at a home location. The first receiver may be in the form of an inwardly-projecting post having an oversized portion for capturing the fluid-agitating element, but various other forms are disclosed. Use of this feature in completely rigid vessels where the fluid-agitating element is free of direct attachment from a first receiver having an oversized portion is also disclosed. In another aspect, the vessel or bag further includes a second receiver for receiving a portion of an external structure, such as a motive device, and aligning the vessel relative thereto.

Abstract: An apparatus for integrity testing a first container having a flexible body at least partially defining a first interior chamber using a second container having a second, preferably sterilized interior chamber at least partially filled with a detectable gas. A sensor associated with a detection chamber for receiving the flexible container, and possibly the second container as well, senses the presence of the detectable gas external to the first interior chamber in the event of a leak of the detectable gas therefrom. Related methods also involve integrity testing of fluid processing bags and other types of flexible containers.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A system for pumping or mixing a fluid using a rotating pumping or mixing element and various other components for use in a pumping or mixing system are disclosed.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A vessel receives and agitates a fluid using an internal fluid-agitating element driven by an external motive device. In one aspect, the vessel is a bag including a first receiver for receiving and holding a fluid-agitating element at a home location. The first receiver may be in the form of an inwardly-projecting post having an oversized portion for capturing the fluid-agitating element, but various other forms are disclosed. Use of this feature in completely rigid vessels where the fluid-agitating element is free of direct attachment from a first receiver having an oversized portion is also disclosed. In another aspect, the vessel or bag further includes a second receiver for receiving a portion of an external structure, such as a motive device, and aligning the vessel relative thereto.

Abstract: A vessel in which a fluid is received and agitated by using an internal fluid-agitating element driven by a non-contact coupling with a motive device external to the vessel. In one aspect, the vessel is a bag including a first receiver for receiving and holding a fluid-agitating element at a home location. The first receiver may be in the form of an inwardly-projecting post having an oversized portion for capturing the fluid-agitating element, but various other forms are disclosed. In another aspect, the vessel or bag further includes a second receiver for receiving a portion of an external structure, such as a motive device, and aligning the vessel relative thereto. Related methods are also disclosed.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A vessel receives and agitates a fluid using an internal fluid-agitating element driven by an external motive device. In one aspect, the vessel is a bag including a first receiver for receiving and holding a fluid-agitating element at a home location. The first receiver may be in the form of an inwardly-projecting post having an oversized portion for capturing the fluid-agitating element, but various other forms are disclosed. Use of this feature in completely rigid vessels where the fluid-agitating element is free of direct attachment from a first receiver having an oversized portion is also disclosed. In another aspect, the vessel or bag further includes a second receiver for receiving a portion of an external structure, such as a motive device, and aligning the vessel relative thereto.

Abstract: Various alignment systems, devices, and related methods are for use in associated with mixing of fluid in a vessel, such as a flexible bag, using an internal fluid-agitating element driven by an external motive device.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: An apparatus detects a leak of an electrically conductive fluid from a disposable plastic bag used in mixing applications, such as during bioprocessing in a sterile environment. In one embodiment, the bag is associated with a sensor for detecting a leak from an interior compartment. The sensor may be arranged to detect either a leak internal to the at least two material layers of the bag or external to the outer layer, or both. Related methods are also disclosed.