Patents by Inventor Alexandre Pellan CHENG

Alexandre Pellan CHENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DETECTING CELL-FREE DNA IN BIOLOGICAL SAMPLES
    Publication number: 20240026456
    Abstract: The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.
    Type: Application
    Filed: August 30, 2023
    Publication date: January 25, 2024
    Applicant: CORNELL UNIVERSITY
    Inventors: Iwijn DE VLAMINCK, John Richard LEE, Philip Smith BURNHAM, Alexandre Pellan CHENG, Manikkam SUTHANTHRIAN, Darshana M. DADHANIA
  • METHODS FOR ASSESSING THE SEVERITY AND PROGRESSION OF SARS-COV2 INFECTIONS USING CELL-FREE DNA
    Publication number: 20230323455
    Abstract: The present disclosure is directed to methods for assessing the severity and progression of a SARS-CoV2 infection in a subject using cell-free DNA (cfDNA). The present disclosure is further directed to methods for assessing tissue damage as a result of SARS-CoV2 infection. In addition, the present disclosure provides methods for treating a SARS-CoV2 infection in a subject. Finally, the disclosure also provides methods for detecting a microbial co-infection of a subject suffering from a SARS-CoV2 infection.
    Type: Application
    Filed: July 23, 2021
    Publication date: October 12, 2023
    Inventors: Iwijn DE VLAMINCK, Alexandre Pellan CHENG, Matthew Pellan CHENG, Donald Cuong VINH, Wei GU, Charles CHIU
  • Methods of detecting cell-free DNA in biological samples
    Patent number: 11781188
    Abstract: The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: October 10, 2023
    Assignee: CORNELL UNIVERSITY
    Inventors: Iwijn De Vlaminck, John Richard Lee, Philip Smith Burnham, Alexandre Pellan Cheng, Manikkam Suthanthrian, Darshana Dadhania
  • METHODS FOR DETECTING TISSUE DAMAGE, GRAFT VERSUS HOST DISEASE, AND INFECTIONS USING CELL-FREE DNA PROFILING
    Publication number: 20230257822
    Abstract: The present disclosure is directed to novel methods for detecting tissue damage, graft-versus-host disease (GVHD), microbial infections, presence of a tumor, and loss of engraftment in a subject using cell-free DNA (cfDNA) profiling. The methods of the disclosure are in part based on the recognition that damaged tissues, microbes during an infection, tumors, and donor cells (e.g., in a hematopoietic cell transplantation) shed small fragments of cfDNA into blood circulation.
    Type: Application
    Filed: April 23, 2021
    Publication date: August 17, 2023
    Inventors: Iwijn DE VLAMINCK, Alexandre Pellan CHENG, Matthew Pellan CHENG, Francisco Miguel MARTY, Jerome RITZ
  • METHODS OF DETECTING CELL-FREE DNA IN BIOLOGICAL SAMPLES
    Publication number: 20200048713
    Abstract: The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.
    Type: Application
    Filed: April 5, 2018
    Publication date: February 13, 2020
    Applicant: CORNELL UNIVERSITY
    Inventors: Iwijn DE VLAMINCK, John Richard LEE, Philip Smith BURNHAM, Alexandre Pellan CHENG, Manikkam SUTHANTHRIAN, Darshana DADHANIA