Abstract: A device (including a head portion, a neck portion, and a body portion) can be removably attached to an arm of an eyeglass frame near the hinge to deliver light therapy to a user's eye. The head portion can include a light source that provides the light therapy to the user's eye. The light therapy can include one or more parameters (e.g., dose, time, etc.) and may be controlled based on the position of the light source. The neck portion can be flexible and moveable to orient the light source towards the eye. The body portion can include a controller, at least one sensor, a power source, and the like. The device can include an attachment mechanism to removably attach the device to the arm of the eyeglass frame.

Abstract: A vitrectomy device includes a carrier having a pocket. A cover is connected to the carrier with at least one of the carrier and the cover has an axle defining an axis. A trigger is pivotably connected to the axle and having a passage. A hollow needle is provided for insertion into the vitreous humor of an eye and extends within the passage. A vacuum sample assembly is received in the pocket and has a chamber under vacuum. The trigger is pivotable about the axle from a first position in which the chamber is not fluidly connected to the needle to a second position in which the needle is bent into fluid communication with the chamber for automatically drawing a vitreous sample through the needle into the chamber under vacuum pressure. Other aspects are also described.

Abstract: The present application describes the addition of various feedback mechanisms including visual and audio feedback mechanisms to an ophthalmic diagnostic device to assist a subject to self-align to the device. The device may use the visual and non-visual feedback mechanisms independently or in combination with one another. The device may provide a means for a subject to provide feedback to the device to confirm that an alignment condition has been met. Alternatively, the device may have a means for sensing when acceptable alignment has been achieved. The device may capture diagnostic information during the alignment process or may capture after the alignment condition has been met.

Abstract: A device for removing vitreous from an eye includes a needle defining a lumen and a port extending to the lumen. The needle is configured for insertion into the vitreous of the eye. A sample container is coupled to the needle and includes a chamber in fluid communication with the lumen and at least at atmospheric pressure. A mechanism is provided for inducing vibration in the needle to draw a sample of the vitreous into the port and to the chamber.

Abstract: A device for removing vitreous from an eye includes a needle defining a lumen and a port extending to the lumen. The needle is configured for insertion into the vitreous of the eye. A sample container is coupled to the needle and includes a chamber in fluid communication with the lumen. A mechanism is provided for inducing vibration in the needle to draw a sample of the vitreous into the port and to the chamber. A drug delivery system is provided for delivering a therapeutic agent through the port. At least one of the sample container and the drug delivery system extends into the vibration inducing mechanism for reducing an overall length of the device.

Abstract: A method of guiding medical treatment of patients receiving an intravitreal injection are described. The method includes obtaining a vitreous sample from a subject receiving an intravitreal injection first treatment, determining the biomarker signature of the sample, reporting the biomarker signature of the sample, and changing the method of treatment to a second treatment if the biomarker signature indicates that use of the second treatment will have a preferable outcome.

Abstract: An intravitreal injection device is provided that includes a therapeutic agent reservoir and a hollow eye penetration member sized and dimensioned to be inserted into the vitreous humor of a patient's eye and in fluid communication with the therapeutic agent reservoir. A tamponade pad configured to contact and apply pressure to a conjunctiva of the patient's eye is translationally coupled to the hollow eye penetration member. The translational coupling between the tamponade pad and the hollow eye penetration member allows the withdrawal of the hollow eye penetration member while maintaining pressure between the tamponade pad and the conjunctiva.

Abstract: A vitrectomy device includes a body extending along an axis from a proximal end to a distal end and having a central passage. A needle is provided for insertion into the vitreous humor of an eye and extends within the central passage and out of the distal end of the body. An assembly including a chamber under vacuum and a piercing member extend away from the chamber. The chamber is movable in a direction transverse to the centerline from a first position in which the chamber is not fluidly connected to the needle to a second position in which the piercing member fluidly connects the chamber to the needle for drawing a vitreous sample into the chamber under vacuum pressure.

Abstract: Systems and methods for improved interferometric imaging are presented. One embodiment is a partial field frequency-domain interferometric imaging system in which a light beam is scanned in two directions across a sample and the light scattered from the object is collected using a spatially resolved detector. The light beam could illuminate a spot, a line or a two-dimensional area on the sample. Additional embodiments with applicability to partial field as well as other types of interferometric systems are also presented.

Abstract: A blister package for ophthalmic drugs that includes a base layer having a first side and a second side. At least one dome extends from the first side with each dome defining a cavity that receives a liquid drug dose. An intermediate layer extends over the second side of the base layer and covers each cavity. The intermediate layer includes an integrally formed nozzle aligned with each cavity. A removable layer extends over the intermediate layer and is releasable from the intermediate layer for uncovering each nozzle opening.

Abstract: Systems and methods for improved interferometric imaging are presented. One embodiment is a partial field frequency-domain interferometric imaging system in which a light beam is scanned in two directions across a sample and the light scattered from the object is collected using a spatially resolved detector. The light beam could illuminate a spot, a line or a two-dimensional area on the sample. Additional embodiments with applicability to partial field as well as other types of interferometric systems are also presented.

Abstract: The present application describes the addition of various feedback mechanisms including visual and audio feedback mechanisms to an ophthalmic diagnostic device to assist a subject to self-align to the device. The device may use the visual and non-visual feedback mechanisms independently or in combination with one another. The device may provide a means for a subject to provide feedback to the device to confirm that an alignment condition has been met. Alternatively, the device may have a means for sensing when acceptable alignment has been achieved. The device may capture diagnostic information during the alignment process or may capture after the alignment condition has been met.

Abstract: Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger than the spectral output bandwidth under the equilibrium conditions.

Abstract: The present application describes the addition of various feedback mechanisms including visual and audio feedback mechanisms to an ophthalmic diagnostic device to assist a subject to elf align to the device. The device may use the visual and non-visual feedback mechanisms independently or in combination with one another. The device may provide a means for a subject to provide feedback to the device to confirm that an alignment condition has been met. Alternatively, the device may have a means for sensing when Acceptable alignment has been achieved. The device may capture diagnostic information during the alignment process or may capture after the alignment condition has been met.

Abstract: A sampling device includes a container having a body defining a chamber and an opening to the chamber. A septum is bonded to the container to cover the opening and hermetically seal the chamber. The septum has an adherent layer with a first thickness and including a material configured to adhere to a rim of the container to provide a hermetic seal with the container. A metallic foil layer having a second thickness is coupled to the adherent layer. An elastomeric layer having a third thickness is coupled to the metallic foil layer to position the metallic foil layer between the adherent layer and the elastomeric layer. The third thickness is greater than the sum of the first thickness and the second thickness.

Abstract: Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger than the spectral output bandwidth under the equilibrium conditions.

Abstract: Ophthalmic imaging systems, particularly slit-scanning ophthalmo-scopes, are capable of characterizing refraction over the entire field of view of the system. Light from the light source of the system illuminates a region of the eye and the returning light is measured on a detector. The deviation of the location of the returning light from a predetermined location on the detector is measured. The deviation corresponds to the mismatch between the refractions of the imaging system and the eye. The light can be scanned across the full field of view to characterize the entire field. A second illumination source traveling along a second illumination path can be used to improve the characterization. The characterization can be of use for optimizing the focus of the instrument and for assessing the condition of the eye, including assessing myopia and astigmatism in the periphery.

Abstract: Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger the spectral output bandwidth under the equilibrium conditions.

Abstract: The present application describes the addition of various feedback mechanisms including visual and audio feedback mechanisms to an ophthalmic diagnostic device to assist a subject to elf align to the device. The device may use the visual and non-visual feedback mechanisms independently or in combination with one another. The device may provide a means for a subject to provide feedback to the device to confirm that an alignment condition has been met. Alternatively, the device may have a means for sensing when Acceptable alignment has been achieved. The device may capture diagnostic information during the alignment process or may capture after the alignment condition has been met.

Abstract: Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger the spectral output bandwidth under the equilibrium conditions.