Patents by Inventor Alexandre TANG

Alexandre TANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NATURAL KILLER (NK) CELL ENGAGERS BINDING TO NKp46 AND BCMA VARIANTS WITH FC-ENGINEERING
    Publication number: 20250197528
    Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-? receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).
    Type: Application
    Filed: November 26, 2024
    Publication date: June 19, 2025
    Inventors: Nicolas GOURDIN, Laurent GAUTHIER, Alexandre TANG, Marielle CHIRON, Angela VIRONE-ODDOS, Alessandro MASIERO, Jochen BENINGA, Ingo FOCKEN, Sambasiva RAO, Yanfeng ZHOU, Leila SEVIGNY
  • Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with Fc-engineering
    Patent number: 12195555
    Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-? receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).
    Type: Grant
    Filed: September 19, 2023
    Date of Patent: January 14, 2025
    Inventors: Nicolas Gourdin, Laurent Gauthier, Alexandre Tang, Marielle Chiron, Angela Virone-Oddos, Alessandro Masiero, Jochen Beninga, Ingo Focken, Sambasiva Rao, Yanfeng Zhou, Leila Sevigny
  • NATURAL KILLER (NK) CELL ENGAGERS BINDING TO NKp46 AND BCMA VARIANTS WITH FC-ENGINEERING
    Publication number: 20240034816
    Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-? receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).
    Type: Application
    Filed: September 19, 2023
    Publication date: February 1, 2024
    Inventors: Nicolas GOURDIN, Laurent GAUTHIER, Alexandre TANG, Marielle CHIRON, Angela VIRONE-ODDOS, Alessandro MASIERO, Jochen BENINGA, Ingo FOCKEN, Sambasiva RAO, Yanfeng ZHOU, Leila SEVIGNY