Patents by Inventor Alexandre V. Lebedev

Alexandre V. Lebedev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES
    Publication number: 20260218175
    Abstract: The present invention includes compositions and methods for the treatment of a medical condition or disease utilizing editing oligonucleotides. The editing oligonucleotides contain a an oligonucleotide strand of about 10 to about 50 nucleotides on each side of the editing moiety which may contain a sugar or linker that positions the active editing moiety in the proper location for hybridization to the target nucleic acid. The editing oligonucleotides may also contain at least one nucleotide sequence change from the targeted sequence in the genome. The method includes modifying a genomic sequence within a cell utilizing an editing oligonucleotide without additional proteins or nucleic acids to assist in the editing process. The editing oligonucleotide may comprise backbone modifications that increase the nuclease stability of the oligonucleotide as compared to unmodified oligonucleotides or oligonucleotides having three phosphorothioates on each terminus.
    Type: Application
    Filed: June 18, 2025
    Publication date: July 30, 2026
    Inventors: Tod M. Woolf, Alexandre V. Lebedev, Richard I. Hogrefe
  • MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION
    Publication number: 20260109977
    Abstract: Described herein are modified RNA molecules where a 3?-stabilizing region is covalently attached to the RNA, and where the 3?-stabilizing region comprises one or more modified nucleosides. Methods of synthesizing said RNAs are also provided herein.
    Type: Application
    Filed: November 12, 2025
    Publication date: April 23, 2026
    Applicant: TriLink BioTechnologies, LLC
    Inventors: Chunping Xu, Chanfeng Zhao, Paul Theodore Ludford, III, Dhamodharan Venugopal, Alexandre V. Lebedev, Hengyuan Lang
  • Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
    Patent number: 12359197
    Abstract: The present invention includes compositions and methods for the treatment of a medical condition or disease utilizing editing oligonucleotides. The editing oligonucleotides contain an oligonucleotide strand of about 10 to about 50 nucleotides on each side of the editing moiety which may contain a sugar or linker that positions the active editing moiety in the proper location for hybridization to the target nucleic acid. The editing oligonucleotides may also contain at least one nucleotide sequence change from the targeted sequence in the genome. The method includes modifying a genomic sequence within a cell utilizing an editing oligonucleotide without additional proteins or nucleic acids to assist in the editing process. The editing oligonucleotide may comprise backbone modifications that increase the nuclease stability of the oligonucleotide as compared to unmodified oligonucleotides or oligonucleotides having three phosphorothioates on each terminus.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 15, 2025
    Assignee: Etagen Pharma, Inc.
    Inventors: Tod M. Woolf, Alexandre V. Lebedev, Richard I. Hogrefe
  • Chimeric oligonucleoside compounds
    Patent number: 6060456
    Abstract: Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target ribonucleic acid sequences, and in treating disease conditions relating to such sequences.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: May 9, 2000
    Assignee: Genta Incorporated
    Inventors: Lyle J. Arnold, Jr., Mark A. Reynolds, Cristina Giachetti, Alexandre V. Lebedev