Patents by Inventor Alexandre Vasilievich Ivachtchenko

Alexandre Vasilievich Ivachtchenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250066358
    Abstract: The present invention is directed to the compounds of Formula (I)—inhibitors of the interaction of menin and MLL. The inhibitors described herein can be useful in the treatment of diseases or disorders associated with menin-MLL interaction, such as cancer. In particular, the invention is concerned with compounds and pharmaceutical compositions inhibiting/blocking menin-MLL interaction, methods of treating diseases or disorders associated with menin-MLL interaction, and methods of synthesizing these compounds.
    Type: Application
    Filed: December 9, 2022
    Publication date: February 27, 2025
    Inventors: Ruben Abagyan, Vladislav Zenonovich Parchinsky, Alexander Khvat, Alexandre Vasilievich Ivachtchenko, Nikolay Savchuk
  • Publication number: 20250032598
    Abstract: The present application is directed to compounds, pharmaceuticals, formulations, and methods for treating and preventing RNA virus infections, particularly infections in mammals. The present application also relates to treating and preventing diseases caused by RNA viruses. In preferred embodiments, the pharmaceuticals, formulations, and methods for treatment and prevention use liposomal aprotinin (Lip-APR).
    Type: Application
    Filed: July 24, 2023
    Publication date: January 30, 2025
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Alena Alexandrovna Ivachtchenko, Ilya Andreevich Ivashchenko, Nikolay Filippovich Savchuk
  • Publication number: 20250011319
    Abstract: The present invention is generally directed to inhibitors of hematopoietic progenitor kinase 1 (HPK1) and FMS-like tyrosine kinase 3 (FLT3) gene, useful in the treatment of diseases and disorders modulated by said HPK1, and FLT3 having the Formula I:
    Type: Application
    Filed: October 3, 2022
    Publication date: January 9, 2025
    Inventors: Ruben Abagyan, Oleg D Mitkin, Vladislav Zenonovich Parchinsky, Alexei Pushechnikov, Alexandre Vasilievich Ivachtchenko, Nikolay Savchuk
  • Publication number: 20240415944
    Abstract: The invention relates to a new aqueous aprotinin-containing antiviral pharmaceutical composition with aprotinin activity from 50 KIU/ml to 950 KIU/ml, optionally containing excipients, for the prevention and treatment of acute respiratory viral infections (ARVI) (acute respiratory infection—ARI). The invention also relates to a new drug for the treatment and prevention of ARVI, comprising said composition in a form suitable for inhalation, nasal or drip use. The medicament can be a nasal spray, or a throat and mouth spray, placed in a vial or vial with a metering valve for a spray or with a dropper dispenser. The medicament can also be aqueous aprotinin-containing antiviral pharmaceutical composition, in a form suitable for inhalation, placed in a vial or vial, container or ampoule for inhalation by a nebulizer. The invention also relates to the use of VASPFC or a drug based on it for the prevention and treatment of ARVI.
    Type: Application
    Filed: April 6, 2021
    Publication date: December 19, 2024
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Nikolay Filippovich Savchuk, Alena Alexandrovna Ivachtchenko
  • Publication number: 20240383918
    Abstract: Substituted 3,4,12,12a-tetrahydro-1H-[1,4]-oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione of general formula 1, its stereoisomer, their prodrug, pharmaceutically acceptable salt, solvate, hydrate, and a crystalline or polycrystalline form thereof where: R1 is 7,8-difluoro-4,9-dihydrothieno[2,23-c][2]benzothiepin-4-yl, R2 is hydrogen or a protective group selected from a series comprising benzyl, (C1-C3 alkyl)oxycarbonyloxy, {[(C1-C3alkyl)oxycarbonyl]-oxy}methoxy, {[2-(C1-C3 alkyl)oxyethoxy]carbonyl}oxy, ({(1R)-2-[(C1-C3alkyl)oxy]-1-methylethoxy}carbonyl) oxy, {[(3S)-ethoxyfuran-3-yloxy]-carbonyl}oxy, [(ethoxy-2H-pyran-4-yloxy)carbonyl]oxy, {[(1-acetylazetidine)-3-yloxy]carbonyl}oxy, {[(C1-C3 alkyl)oxycarbonyl]oxy}methoxy, ({[2-(C1-C3 alkyl)oxyethoxy]carbonyl}oxy) methoxy.
    Type: Application
    Filed: July 25, 2024
    Publication date: November 21, 2024
    Applicant: VIRIOM, INC.
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Oleg Dmitrievich Mitkin
  • Publication number: 20240383919
    Abstract: Substituted 3,4,12,12a-tetrahydro-1H-[1,4]-oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione of general formula 1, its stereoisomer, their prodrug, pharmaceutically acceptable salt, solvate, hydrate, and a crystalline or polycrystalline form thereof where: R1 is diphenylmethyl, bis(4-fluorophenyl)methyl, (3,4-difluorophenyl)(phenyl)methyl, (3,4-difluorophenyl)(2-methylsulfanylphenyl)methyl; R2 is hydrogen or a {[(C1-C3alkyl)oxycarbonyl]-oxy}methoxy and stereoisomers thereof.
    Type: Application
    Filed: July 25, 2024
    Publication date: November 21, 2024
    Applicant: VIRIOM, INC.
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Oleg Dmitrievich Mitkin
  • Patent number: 12091423
    Abstract: Influenza is an acute infectious respiratory disease caused by the influenza virus. It is part of the group of Acute Respiratory Viral Infections (ARVI). It occasionally spreads in the form of epidemics and pandemics. Currently, more than 2000 variants of the influenza virus differing in the antigen spectrum have been identified. Given that influenza is a serious threat to public health (worldwide, these annual epidemics lead to 3-5 million cases of severe illness, millions of hospitalizations, and up to 650,000 deaths), it seems appropriate to search for new anti-influenza drugs with improved characteristics.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: September 17, 2024
    Assignee: VIRIOM, INC.
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Oleg Dmitrievich Mitkin
  • Publication number: 20240270699
    Abstract: The present invention is generally directed to inhibitors of hematopoietic progenitor kinase 1 (HPK1), leucine rich repeat kinase 2 (LRRK2) protein, FMS-like tyrosine kinase 3 (FLT3) gene, interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), and Janus kinases (JAKs), including Janus kinase 1 (JAK1), Janus kinase 2 (JAK2), Janus kinase 3 (JAK3), and tyrosine kinase 2 (TYK2) useful in the treatment of diseases and disorders modulated by said HPK1, LRRK2, FLT3, IRAK1, IRAK4, and JAKs, having the Formula (I):
    Type: Application
    Filed: March 13, 2024
    Publication date: August 15, 2024
    Inventors: Volodymyr Kysil, Vladislav Zenonovich Parchinsky, Alexei Pushechnikov, Alexandre Vasilievich Ivachtchenko, Nikolay Savchuk
  • Publication number: 20240262801
    Abstract: The present invention is generally directed to inhibitors of protein tyrosine phosphatase enzymes useful in the treatment of diseases and disorders modulated by said enzymes and having the Formula (I):
    Type: Application
    Filed: December 8, 2023
    Publication date: August 8, 2024
    Inventors: Volodymyr Kysil, Vladislav Zenonovich Parchinsky, Alexei Pushechnikov, Alexandre Vasilievich Ivachtchenko, Nikolay Savchuk
  • Publication number: 20240238260
    Abstract: The present invention relates to a novel Noradrenergic and Specific Serotonergic Anxiolytic and Antidepressant (NaSSA) and a method for the production and use thereof for treating mental disorders. The subject of this invention is a novel noradrenergic and specific serotonergic drug for the treatment of mental disorders in humans, which is 2,8-dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride (A·HCl), a polymorphous modification thereof, and methods for the production and use thereof.
    Type: Application
    Filed: March 27, 2020
    Publication date: July 18, 2024
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko
  • Publication number: 20240043424
    Abstract: The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I):
    Type: Application
    Filed: September 12, 2023
    Publication date: February 8, 2024
    Applicant: Eil Therapeutics, Inc.
    Inventors: Volodymyr Kysil, Vladislav Zenonovich Parchinsky, Alexei Pushechnikov, Alexandre Vasilievich Ivachtchenko, Ruben Abagyan, Andrew Orry, Polo Chun-Hung Lam, Nikolay Savchuk
  • Patent number: 11834450
    Abstract: The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I):
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: December 5, 2023
    Assignee: EIL THERAPEUTICS, INC.
    Inventors: Volodymyr Kysil, Vladislav Zenonovich Parchinsky, Alexei Pushechnikov, Alexandre Vasilievich Ivachtchenko, Ruben Abagyan, Andrew Orry, Polo Chun-Hung Lam, Nikolay Savchuk
  • Publication number: 20230372458
    Abstract: This invention relates to a novel anti-coronavirus agent for COVID-19 (SARS-CoV-2) combination therapy. The agent comprises, in a therapeutically effective amount and ratio, aprotinin (APR) or a medicinal drug based thereon and a SARS-CoV-2 replication inhibitor. The aprotinin-based medicinal drug is preferably selected from the group consisting of Aprotex, Vero-Narcap, Ingitril, Contrykal, Kontrisel, Trasilol®, Ingiprol, Aprotimbin, Gordox®, Contriven, Trascolan, or Aerus. For SARS-CoV-2 replication inhibitor one can use favipiravir (FPV) or Remdesivir (RMD), or a medicinal drug based thereon. The favipiravir-based medicinal drug is preferably selected from the group consisting of Avigan, Favilavir, Avifavir, Coronavir, or Fabiflu. Further, the invention relates to a combination method to treat COVID-19 (SARS-CoV-2) by administering said anti-coronavirus agent to a patient with COVID-19.
    Type: Application
    Filed: December 17, 2020
    Publication date: November 23, 2023
    Inventors: Alexandre Vasilievich IVACHTCHENKO, Nikolay Filippovich SAVCHUK, Alena Alexandrovna IVACHTCHENKO, Vladimir Grigorievich LOGINOV, Mikhail TOPR, Andrey Alexandrovich IVASHCHENKO
  • Publication number: 20230357238
    Abstract: The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (A):
    Type: Application
    Filed: July 14, 2023
    Publication date: November 9, 2023
    Applicant: Eil Therapeutics, Inc.
    Inventors: Volodymyr KYSIL, Vladislav Zenonovich PARCHINSKY, Alexei PUSHECHNIKOV, Alexandre Vasilievich IVACHTCHENKO, Ruben ABAGYAN, Andrew ORRY, Polo Chun-Hung LAM, Nikolay SAVCHUK
  • Publication number: 20230346899
    Abstract: The present application relates to the new the pharmaceutical combination therapy and prevention of SARS-CoV-2 and/or disease associated with this infection, including viral and bacterial pneumonia and COVID-19, using aprotinin (APR), ribavirin and / or nirmatrelvir (NIMR), the pharmaceutical kit and the pharmaceutical composition for this pharmaceutical combination therapy and prevention of SARS-CoV-2 and/or disease associated with this infection, including COVID-19.
    Type: Application
    Filed: April 10, 2023
    Publication date: November 2, 2023
    Applicants: ASAVI LLC
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Alena Alexandrovna Ivachtchenko, Ilya Andreevich Ivashchenko, Nikolay Filippovich Savchuk
  • Publication number: 20230310480
    Abstract: The application relates to pharmaceutical combinations, methods, and therapies for the treatment and prevention of SARS-CoV-2 infection and related diseases. The combinations contain aprotinin and molnupiravir, and/or favipiravir. The application also includes related pharmaceutical kits. Further details are described in the specification.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 5, 2023
    Applicants: ASAVI LLC
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Alena Alexandrovna Ivachtchenko, Ilya Andreevich Ivashchenko, Nikolay Filippovich Savchuk
  • Publication number: 20230310544
    Abstract: A pharmaceutical combination prevention and treatment of RNA virus infection and/or a disease associated with this infection, of acute respiratory viral infections (ARVI) and severe acute respiratory syndrome (SARS), including viral and bacterial pneumonia and COVID-19, using aprotinin (APR) and an anti-RNA ingredient. A pharmaceutical kit and pharmaceutical composition in the form of an aqueous solution (APC) or a lyophilizate (PCL) for a pharmaceutical combination treatment and prevention of RNA virus infection and/or a disease associated with this infection.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 5, 2023
    Applicants: ASAVI LLC
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Alena Alexandrovna Ivachtchenko, Ilya Andreevich Ivashchenko, Nikolay Filippovich Savchuk
  • Publication number: 20230310467
    Abstract: The application relates to pharmaceutical combinations, methods, and therapies for the treatment and prevention of SARS-CoV-2 infection and related diseases. The combinations contain aprotinin, baricitinib, and/or remdesivir. The application also includes related pharmaceutical kits. Further details are described in the specification.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 5, 2023
    Applicants: ASAVI LLC
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Alena Alexandrovna Ivachtchenko, Ilya Andreevich Ivashchenko, Nikolay Filippovich Savchuk
  • Patent number: 11697650
    Abstract: The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I):
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: July 11, 2023
    Assignee: Eil Therapeutics, Inc.
    Inventors: Volodymyr Kysil, Vladislav Zenonovich Parchinsky, Alexei Pushechnikov, Alexandre Vasilievich Ivachtchenko, Ruben Abagyan, Andrew Orry, Polo Chun-Hung Lam, Nikolay Savchuk
  • Publication number: 20230181704
    Abstract: This invention relates to a novel anti-SARS-CoV-2 virus agent Antiprovir to be used for the prevention and treatment of coronavirus disease COVID-19. The use of a pharmaceutical composition, including Aprotex®, Gordox® and Aerus®, with aprotinin as the active ingredient and excipients, said pharmaceutical composition being anti-SARS-CoV-2 virus drug Antiprovir to be used for the prevention and treatment of coronavirus disease COVID-19. The drug Antiprovir for the prevention and treatment of coronavirus disease COVID-19, which is a pharmaceutical composition containing 0.1% wt. ÷ 0.2% wt. aprotinin, optionally 0.2 %wt. ÷ 1.0% wt. excipients, and the rest is water for injection.
    Type: Application
    Filed: July 3, 2020
    Publication date: June 15, 2023
    Inventors: Alexandre Vasilievich Ivachtchenko, Andrey Alexandrovich Ivashchenko, Nikolay Filippovich Savchuk, Alena Alexandrovna Ivachtchenko, Vladimir Grigorievich Loginov, Mikhail Topr