Patents by Inventor Alexandre Zysman

Alexandre Zysman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5773611
    Abstract: The invention relates to ceramides of formula: ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical; R.sub.2 denotes a C.sub.11 -C.sub.19 hydrocarbon radical, which is linear and carries one or more ethylenic unsaturations, and in particular one or two, or a mixture of C.sub.11 -C.sub.19 hydrocarbon radicals, which are linear, saturated or carry one or more ethylenic unsaturations, and in particular one or two, in which the proportion of saturated radicals cannot exceed 35%, these compounds being in the form of a racemic mixture of the erythro and threo diastereoisomers in the erythro:threo proportions of 85:15 to 60:40.The invention also relates to the process for preparing the compounds as well as their applications in the cosmetic and dermopharmaceutical fields.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: June 30, 1998
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Guy Vanlerberghe, Didier Semeria
  • Patent number: 5618523
    Abstract: The invention relates to ceramides of formula: ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical; R.sub.2 denotes a C.sub.11 -C.sub.19 hydrocarbon radical, which is linear and carries one or more ethylenic unsaturations, and in particular one or two, or a mixture of C.sub.11 -C.sub.19 hydrocarbon radicals, which are linear, saturated or carry one or more ethylenic unsaturations, and in particular one or two, in which the proportion of saturated radicals cannot exceed 35%, these compounds being in the form of a racemic mixture of the erythro and threo diastereoisomers in the erythro:threo proportions of 85:15 to 60:40.The invention also relates to the process for preparing the compounds as well as their applications in the cosmetic and dermopharmaceutical fields.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: April 8, 1997
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Guy Vanlerberghe, Didier Semeria
  • Patent number: 5539129
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: July 23, 1996
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag, Alain Ribier, Guy Vanlerberghe, Claude Mahieu, Claude Berthelot
  • Patent number: 5431905
    Abstract: A compound of the formula:R--NHCOOCH(CH.sub.2 OCH.sub.2 CHOHCH.sub.2 OH).sub.2 (I)wherein R is a C.sub.10 -C.sub.20 alkyl, optionally unsaturated, is employed in the preparation of wax microdispersions useful particularly in cosmetic composition for the hair.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: July 11, 1995
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag
  • Patent number: 5371252
    Abstract: A compound of the formula:R--NHCOOCH(CH.sub.2 OCH.sub.2 CHOHCH.sub.2 OH).sub.2 (I)wherein R is a C.sub.10 -C.sub.20 alkyl, optionally unsaturated, is employed in the preparation of wax microdispersions useful particularly in cosmetic composition for the hair.
    Type: Grant
    Filed: November 10, 1992
    Date of Patent: December 6, 1994
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag
  • Patent number: 5362494
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: November 8, 1994
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag, Alain Ribier, Guy Vanlerberghe, Claude Mahieu, Claude Berthelot
  • Patent number: 5290565
    Abstract: Composition for promoting healing containing, as a healing agent, nonionic vesicles obtained from a lipid mixture containing at least one nonionic lipid having the formula; ##STR1## wherein R is either at least one C.sub.16 -C.sub.18 radical, or R'CO wherein R' is at least one C.sub.15 -C.sub.17 alkyl radical, in combination with cholesterol and, optionally, dicetylphosphate or tetracetylphospate.This composition can be used topically to accelerate the scarring of wounds.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: March 1, 1994
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag, Guy Vanlerberghe, Rose-Marie Handjani, Alain Ribier
  • Patent number: 5198470
    Abstract: The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use or pharmaceutical use for skin conditions containing this compound.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: March 30, 1993
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Guy Vanlerberghe, Henri Sebag
  • Patent number: 5164488
    Abstract: The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:C.sub.2 H.sub.4 O.sub.r and/orC.sub.3 H.sub.5 (OH)O.sub.s,in which r denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 or 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.
    Type: Grant
    Filed: February 13, 1991
    Date of Patent: November 17, 1992
    Assignee: L'Oreal
    Inventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
  • Patent number: 5149860
    Abstract: The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use of pharmaceutical use for skin conditions containing this compound.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: September 22, 1992
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Guy Vanlerberghe, Henri Sebag
  • Patent number: 5124081
    Abstract: Amphiphilic lipid compound having the formula: ##STR1## in which: R.sub.1 denotes a C.sub.7 -C.sub.21 alkyl or alkenyl radical,R.sub.2 denotes a saturated or unsaturated C.sub.7 -C.sub.31 hydrocarbon radical,COA denotes a group chosen from the following groups:a) COOM, M being H, Na, K, NH.sub.4 or a substituted ammonium ion derived from an amine,b) ##STR2## B being a radical derived from mono- or polyhydroxylated primary or secondary amines and R denoting a hydrogen atom or a methyl, ethyl or hydroxyethyl radical,c) ##STR3## Q denoting a substituted aminoalkyl or ammonioalkyl radical and R having the meaning indicated for b), andd) COOZ, Z representing the residue of a C.sub.3 -C.sub.7 polyol, and a process for its preparation.Cosmetic or dermopharmaceutical composition comprising the said compound and especially an aqueous dispersion of liposomes.
    Type: Grant
    Filed: June 24, 1986
    Date of Patent: June 23, 1992
    Assignee: L'Oreal
    Inventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
  • Patent number: 5008406
    Abstract: The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:--C.sub.2 H.sub.4 O--.sub.rand/or--C.sub.3 H.sub.5 (OH)O--.sub.s,in which r denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 or 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.
    Type: Grant
    Filed: April 20, 1989
    Date of Patent: April 16, 1991
    Assignee: L'Oreal
    Inventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
  • Patent number: 4940575
    Abstract: 4-Hydroxyisoxazole derivatives corresponding to the formula: ##STR1## wherein: R represents a linear or branched alkyl or hydroxyalkyl radical with 1 to 23 carbon atoms, a linear or branched alkenyl radical with 2 to 23 carbon atoms, a phenyl radical, or a benzyl radical, andR.sub.1 represents OR.sub.2, --NHR.sub.3, or --NH--NHR.sub.4,R.sub.2 represents a hydrogen atom or an alkyl radical with 1 to 24 carbon atoms,R.sub.3 represents a hydrogen atom, an alkyl radical with 1 to 20 carbon atoms, or a ##STR2## radical, where n is 2 to 3 and r' and r" are identical or different, representing a hydrogen atom or a lower alkyl radical or forming a heterocycle when taken together such as morpholine, piperidine, or piperazine,R.sub.4 represents a hydrogen atom or a benzyl radical,and the salts of the formula (I) compounds.These derivatives are applicable to therapeutic and cosmetic fields, in particular to counteract the harmful effects of the sun.
    Type: Grant
    Filed: June 26, 1989
    Date of Patent: July 10, 1990
    Assignee: Societe Anonyme dite:L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag
  • Patent number: 4827003
    Abstract: The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:--C.sub.2 H.sub.4 O--.sub.rand/or--C.sub.3 H.sub.5 (OH)O--.sub.s,in whichr denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 to 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: May 2, 1989
    Assignee: L'Oreal
    Inventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
  • Patent number: 4587321
    Abstract: Quaternary siloxane polymers of the formula: ##STR1## in which A denotes an .alpha.,.beta.-bis-alkylpolysiloxane or a C.sub.1-6 hydrocarbon chain which can contain OH groups and can be interrupted by one or more oxygen atoms and/or aromatic rings; R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which are identical or different, denote a C.sub.1 -C.sub.6 alkyl or phenyl; R.sub.5 =methyl, ethyl or --CH.sub.2 --; R.sub.6 =C.sub.1 -C.sub.18 alkyl or --CH.sub.2 --; if R.sub.5 and/or R.sub.6 denote --CH.sub.2 --, they form a methylpiperazinium radical or ethylpiperazinium radical, a diethylenediamine radical or a heterocycle with --N--A--N--; Y denotes one of the anions Cl.sup.-, Br.sup.-, CH.sub.3 SO.sub.3.sup.-, ##STR2## m=1-6; and p=1-50 are disclosed for use, in particular, for treating the hair, nails and skin. They are resistant to several rinses on these substrates.
    Type: Grant
    Filed: April 1, 1985
    Date of Patent: May 6, 1986
    Assignee: L'Oreal
    Inventors: Henri Sebag, Alexandre Zysman
  • Patent number: 4533714
    Abstract: Quaternary siloxane polymers of the formula: ##STR1## in which A denotes an .alpha.,.beta.-bis-alkylpolysiloxane or a C.sub.1-6 hydrocarbon chain which can contain OH groups and can be interrupted by one or more oxygen atoms and/or aromatic rings; R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which are identical or different, denote a C.sub.1 -C.sub.6 alkyl or phenyl; R.sub.5 =methyl, ethyl or --CH.sub.2 --; R.sub.6 =C.sub.1 -C.sub.18 alkyl or --CH.sub.2 --; if R.sub.5 and/or R.sub.6 denote --CH.sub.2 --, they form a methylpiperazinium radical or ethylpiperazinium radical, a diethylenediamine radical or a heterocycle with --N--A--N--; Y denotes one of the anions Cl.sup.-, Br.sup.-, CH.sub.3 SO.sub.3.sup.-, ##STR2## m=1-6; and p=1-50 are disclosed for use, in particular, for treating the hair, nails and skin. They are resistant to several rinses on these substrates.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: August 6, 1985
    Assignee: L'Oreal
    Inventors: Henri Sebag, Alexandre Zysman
  • Patent number: 4371517
    Abstract: The invention provides compositions intended for the treatment of fibrous materials. These compositions contain at least one cationic polymer, at least one anionic polymer, at least one alkali metal salt and at least one non-ionic surface-active agent or surface-active agent which contains one or more carboxyl or carboxylate groups in addition to non-ionic groups.
    Type: Grant
    Filed: September 12, 1979
    Date of Patent: February 1, 1983
    Assignee: L'Oreal
    Inventors: Guy Vanlerberghe, Henri Sebag, Alexandre Zysman, Claude Dubief
  • Patent number: 4349532
    Abstract: Composition suitable for treating the hair or skin, which conains at least one poly-(quaternary ammonium) polymer having units of the formula: ##STR1## in which A denotes an alkylene, hydroxyalkylene, alkenylene or alkynylene radical;B denotes:(a) --O--Z--O-- in which Z denotes a hydrocarbon radical or a group ##STR2## in which x and 4 denote a number from 1 to 4; (b) a bis-secondary diamine radical;(c) a radical --NH--Y--NH-- in which Y denotes a hydrocarbon radical or the radical --CH.sub.2 --CH.sub.2 --S--S--CH.sub.2 --CH.sub.2 --; or(d) a group --NH--CO--NH--;R.sub.1 denotes C.sub.1 -C.sub.4 alkyl; R.sub.2 denotes a hydrocarbon radical or two R.sub.2 radicals can complete a radical ##STR3## X denotes a halide; and n is 1 or an integer from 3 to 10. The polymers used in the composition of the invention have a good compatibility with anionic surface-active agents, are degradable and do not accumulate on the hair.
    Type: Grant
    Filed: September 14, 1978
    Date of Patent: September 14, 1982
    Inventors: Guy Vanlerberghe, Henri Sebag, Alexandre Zysman
  • Patent number: 4277581
    Abstract: A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di-carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis-primary and mono- and bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of (a') simple bi-functional compounds selected from bis-halohydrins, bis-azetidinium, bis-haloacyl diamine and alkyl bis-halides, (b') ol
    Type: Grant
    Filed: July 16, 1979
    Date of Patent: July 7, 1981
    Assignee: L'Oreal
    Inventors: Guy Vanlerberghe, Henri Sebag, Jean-Francois Grollier, Alexandre Zysman
  • Patent number: 4275054
    Abstract: A polyanionic polyamide salt which comprises chain units of the formula: ##STR1## in which X denotes ##STR2## R being an aliphatic radical containing 1 to 4 carbon atoms, each Y independently denotes a divalent aliphatic or cycloaliphatic radical, Z denotes a divalent radical of the formula: ##STR3## and M.sup.+ denotes a sodium or potassium ion or a quaternary ammonium ion of the formula: ##STR4## in which each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently denotes a hydrogen atom or a methyl, ethyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, methylhydroxypropyl or methyl-dihydroxypropyl radical, the viscosity of a 5% by weight aqueous solution of the salt being from 1 to 500 centipoises at a temperature of 25.degree. C., are provided which act as deodorants and deodorisers.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: June 23, 1981
    Assignee: L'Oreal
    Inventors: Henri Sebag, Alexandre Zysman, Guy Vanlerberghe