Patents by Inventor Alexandre Zysman
Alexandre Zysman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5773611Abstract: The invention relates to ceramides of formula: ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical; R.sub.2 denotes a C.sub.11 -C.sub.19 hydrocarbon radical, which is linear and carries one or more ethylenic unsaturations, and in particular one or two, or a mixture of C.sub.11 -C.sub.19 hydrocarbon radicals, which are linear, saturated or carry one or more ethylenic unsaturations, and in particular one or two, in which the proportion of saturated radicals cannot exceed 35%, these compounds being in the form of a racemic mixture of the erythro and threo diastereoisomers in the erythro:threo proportions of 85:15 to 60:40.The invention also relates to the process for preparing the compounds as well as their applications in the cosmetic and dermopharmaceutical fields.Type: GrantFiled: February 26, 1997Date of Patent: June 30, 1998Assignee: L'OrealInventors: Alexandre Zysman, Guy Vanlerberghe, Didier Semeria
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Patent number: 5618523Abstract: The invention relates to ceramides of formula: ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical; R.sub.2 denotes a C.sub.11 -C.sub.19 hydrocarbon radical, which is linear and carries one or more ethylenic unsaturations, and in particular one or two, or a mixture of C.sub.11 -C.sub.19 hydrocarbon radicals, which are linear, saturated or carry one or more ethylenic unsaturations, and in particular one or two, in which the proportion of saturated radicals cannot exceed 35%, these compounds being in the form of a racemic mixture of the erythro and threo diastereoisomers in the erythro:threo proportions of 85:15 to 60:40.The invention also relates to the process for preparing the compounds as well as their applications in the cosmetic and dermopharmaceutical fields.Type: GrantFiled: February 2, 1995Date of Patent: April 8, 1997Assignee: L'OrealInventors: Alexandre Zysman, Guy Vanlerberghe, Didier Semeria
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Patent number: 5539129Type: GrantFiled: July 22, 1994Date of Patent: July 23, 1996Assignee: L'OrealInventors: Alexandre Zysman, Henri Sebag, Alain Ribier, Guy Vanlerberghe, Claude Mahieu, Claude Berthelot
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Patent number: 5431905Abstract: A compound of the formula:R--NHCOOCH(CH.sub.2 OCH.sub.2 CHOHCH.sub.2 OH).sub.2 (I)wherein R is a C.sub.10 -C.sub.20 alkyl, optionally unsaturated, is employed in the preparation of wax microdispersions useful particularly in cosmetic composition for the hair.Type: GrantFiled: July 29, 1994Date of Patent: July 11, 1995Assignee: L'OrealInventors: Alexandre Zysman, Henri Sebag
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Patent number: 5371252Abstract: A compound of the formula:R--NHCOOCH(CH.sub.2 OCH.sub.2 CHOHCH.sub.2 OH).sub.2 (I)wherein R is a C.sub.10 -C.sub.20 alkyl, optionally unsaturated, is employed in the preparation of wax microdispersions useful particularly in cosmetic composition for the hair.Type: GrantFiled: November 10, 1992Date of Patent: December 6, 1994Assignee: L'OrealInventors: Alexandre Zysman, Henri Sebag
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Patent number: 5362494Type: GrantFiled: July 14, 1992Date of Patent: November 8, 1994Assignee: L'OrealInventors: Alexandre Zysman, Henri Sebag, Alain Ribier, Guy Vanlerberghe, Claude Mahieu, Claude Berthelot
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Patent number: 5290565Abstract: Composition for promoting healing containing, as a healing agent, nonionic vesicles obtained from a lipid mixture containing at least one nonionic lipid having the formula; ##STR1## wherein R is either at least one C.sub.16 -C.sub.18 radical, or R'CO wherein R' is at least one C.sub.15 -C.sub.17 alkyl radical, in combination with cholesterol and, optionally, dicetylphosphate or tetracetylphospate.This composition can be used topically to accelerate the scarring of wounds.Type: GrantFiled: May 13, 1992Date of Patent: March 1, 1994Assignee: L'OrealInventors: Alexandre Zysman, Henri Sebag, Guy Vanlerberghe, Rose-Marie Handjani, Alain Ribier
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Patent number: 5198470Abstract: The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use or pharmaceutical use for skin conditions containing this compound.Type: GrantFiled: June 25, 1992Date of Patent: March 30, 1993Assignee: L'OrealInventors: Alexandre Zysman, Guy Vanlerberghe, Henri Sebag
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Patent number: 5164488Abstract: The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:C.sub.2 H.sub.4 O.sub.r and/orC.sub.3 H.sub.5 (OH)O.sub.s,in which r denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 or 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.Type: GrantFiled: February 13, 1991Date of Patent: November 17, 1992Assignee: L'OrealInventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
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Patent number: 5149860Abstract: The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use of pharmaceutical use for skin conditions containing this compound.Type: GrantFiled: September 20, 1990Date of Patent: September 22, 1992Assignee: L'OrealInventors: Alexandre Zysman, Guy Vanlerberghe, Henri Sebag
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Patent number: 5124081Abstract: Amphiphilic lipid compound having the formula: ##STR1## in which: R.sub.1 denotes a C.sub.7 -C.sub.21 alkyl or alkenyl radical,R.sub.2 denotes a saturated or unsaturated C.sub.7 -C.sub.31 hydrocarbon radical,COA denotes a group chosen from the following groups:a) COOM, M being H, Na, K, NH.sub.4 or a substituted ammonium ion derived from an amine,b) ##STR2## B being a radical derived from mono- or polyhydroxylated primary or secondary amines and R denoting a hydrogen atom or a methyl, ethyl or hydroxyethyl radical,c) ##STR3## Q denoting a substituted aminoalkyl or ammonioalkyl radical and R having the meaning indicated for b), andd) COOZ, Z representing the residue of a C.sub.3 -C.sub.7 polyol, and a process for its preparation.Cosmetic or dermopharmaceutical composition comprising the said compound and especially an aqueous dispersion of liposomes.Type: GrantFiled: June 24, 1986Date of Patent: June 23, 1992Assignee: L'OrealInventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
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Patent number: 5008406Abstract: The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:--C.sub.2 H.sub.4 O--.sub.rand/or--C.sub.3 H.sub.5 (OH)O--.sub.s,in which r denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 or 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.Type: GrantFiled: April 20, 1989Date of Patent: April 16, 1991Assignee: L'OrealInventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
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Patent number: 4940575Abstract: 4-Hydroxyisoxazole derivatives corresponding to the formula: ##STR1## wherein: R represents a linear or branched alkyl or hydroxyalkyl radical with 1 to 23 carbon atoms, a linear or branched alkenyl radical with 2 to 23 carbon atoms, a phenyl radical, or a benzyl radical, andR.sub.1 represents OR.sub.2, --NHR.sub.3, or --NH--NHR.sub.4,R.sub.2 represents a hydrogen atom or an alkyl radical with 1 to 24 carbon atoms,R.sub.3 represents a hydrogen atom, an alkyl radical with 1 to 20 carbon atoms, or a ##STR2## radical, where n is 2 to 3 and r' and r" are identical or different, representing a hydrogen atom or a lower alkyl radical or forming a heterocycle when taken together such as morpholine, piperidine, or piperazine,R.sub.4 represents a hydrogen atom or a benzyl radical,and the salts of the formula (I) compounds.These derivatives are applicable to therapeutic and cosmetic fields, in particular to counteract the harmful effects of the sun.Type: GrantFiled: June 26, 1989Date of Patent: July 10, 1990Assignee: Societe Anonyme dite:L'OrealInventors: Alexandre Zysman, Henri Sebag
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Patent number: 4827003Abstract: The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:--C.sub.2 H.sub.4 O--.sub.rand/or--C.sub.3 H.sub.5 (OH)O--.sub.s,in whichr denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 to 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.Type: GrantFiled: June 13, 1986Date of Patent: May 2, 1989Assignee: L'OrealInventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag
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Patent number: 4587321Abstract: Quaternary siloxane polymers of the formula: ##STR1## in which A denotes an .alpha.,.beta.-bis-alkylpolysiloxane or a C.sub.1-6 hydrocarbon chain which can contain OH groups and can be interrupted by one or more oxygen atoms and/or aromatic rings; R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which are identical or different, denote a C.sub.1 -C.sub.6 alkyl or phenyl; R.sub.5 =methyl, ethyl or --CH.sub.2 --; R.sub.6 =C.sub.1 -C.sub.18 alkyl or --CH.sub.2 --; if R.sub.5 and/or R.sub.6 denote --CH.sub.2 --, they form a methylpiperazinium radical or ethylpiperazinium radical, a diethylenediamine radical or a heterocycle with --N--A--N--; Y denotes one of the anions Cl.sup.-, Br.sup.-, CH.sub.3 SO.sub.3.sup.-, ##STR2## m=1-6; and p=1-50 are disclosed for use, in particular, for treating the hair, nails and skin. They are resistant to several rinses on these substrates.Type: GrantFiled: April 1, 1985Date of Patent: May 6, 1986Assignee: L'OrealInventors: Henri Sebag, Alexandre Zysman
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Patent number: 4533714Abstract: Quaternary siloxane polymers of the formula: ##STR1## in which A denotes an .alpha.,.beta.-bis-alkylpolysiloxane or a C.sub.1-6 hydrocarbon chain which can contain OH groups and can be interrupted by one or more oxygen atoms and/or aromatic rings; R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which are identical or different, denote a C.sub.1 -C.sub.6 alkyl or phenyl; R.sub.5 =methyl, ethyl or --CH.sub.2 --; R.sub.6 =C.sub.1 -C.sub.18 alkyl or --CH.sub.2 --; if R.sub.5 and/or R.sub.6 denote --CH.sub.2 --, they form a methylpiperazinium radical or ethylpiperazinium radical, a diethylenediamine radical or a heterocycle with --N--A--N--; Y denotes one of the anions Cl.sup.-, Br.sup.-, CH.sub.3 SO.sub.3.sup.-, ##STR2## m=1-6; and p=1-50 are disclosed for use, in particular, for treating the hair, nails and skin. They are resistant to several rinses on these substrates.Type: GrantFiled: November 7, 1983Date of Patent: August 6, 1985Assignee: L'OrealInventors: Henri Sebag, Alexandre Zysman
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Patent number: 4371517Abstract: The invention provides compositions intended for the treatment of fibrous materials. These compositions contain at least one cationic polymer, at least one anionic polymer, at least one alkali metal salt and at least one non-ionic surface-active agent or surface-active agent which contains one or more carboxyl or carboxylate groups in addition to non-ionic groups.Type: GrantFiled: September 12, 1979Date of Patent: February 1, 1983Assignee: L'OrealInventors: Guy Vanlerberghe, Henri Sebag, Alexandre Zysman, Claude Dubief
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Patent number: 4349532Abstract: Composition suitable for treating the hair or skin, which conains at least one poly-(quaternary ammonium) polymer having units of the formula: ##STR1## in which A denotes an alkylene, hydroxyalkylene, alkenylene or alkynylene radical;B denotes:(a) --O--Z--O-- in which Z denotes a hydrocarbon radical or a group ##STR2## in which x and 4 denote a number from 1 to 4; (b) a bis-secondary diamine radical;(c) a radical --NH--Y--NH-- in which Y denotes a hydrocarbon radical or the radical --CH.sub.2 --CH.sub.2 --S--S--CH.sub.2 --CH.sub.2 --; or(d) a group --NH--CO--NH--;R.sub.1 denotes C.sub.1 -C.sub.4 alkyl; R.sub.2 denotes a hydrocarbon radical or two R.sub.2 radicals can complete a radical ##STR3## X denotes a halide; and n is 1 or an integer from 3 to 10. The polymers used in the composition of the invention have a good compatibility with anionic surface-active agents, are degradable and do not accumulate on the hair.Type: GrantFiled: September 14, 1978Date of Patent: September 14, 1982Inventors: Guy Vanlerberghe, Henri Sebag, Alexandre Zysman
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Patent number: 4277581Abstract: A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di-carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis-primary and mono- and bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of (a') simple bi-functional compounds selected from bis-halohydrins, bis-azetidinium, bis-haloacyl diamine and alkyl bis-halides, (b') olType: GrantFiled: July 16, 1979Date of Patent: July 7, 1981Assignee: L'OrealInventors: Guy Vanlerberghe, Henri Sebag, Jean-Francois Grollier, Alexandre Zysman
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Patent number: 4275054Abstract: A polyanionic polyamide salt which comprises chain units of the formula: ##STR1## in which X denotes ##STR2## R being an aliphatic radical containing 1 to 4 carbon atoms, each Y independently denotes a divalent aliphatic or cycloaliphatic radical, Z denotes a divalent radical of the formula: ##STR3## and M.sup.+ denotes a sodium or potassium ion or a quaternary ammonium ion of the formula: ##STR4## in which each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently denotes a hydrogen atom or a methyl, ethyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, methylhydroxypropyl or methyl-dihydroxypropyl radical, the viscosity of a 5% by weight aqueous solution of the salt being from 1 to 500 centipoises at a temperature of 25.degree. C., are provided which act as deodorants and deodorisers.Type: GrantFiled: August 27, 1979Date of Patent: June 23, 1981Assignee: L'OrealInventors: Henri Sebag, Alexandre Zysman, Guy Vanlerberghe