Abstract: An end member assembly (EMI) with a longitudinal axis is securable to a flexible spring member (400). The end member assembly (EMI) has first and second ends. The end member assembly (EMI) includes first end member component (500) with a first component wall (502) includes an end wall portion (504) and a side wall portion (506). A second end member component (600) extends peripherally around and is permanently attached to the first end member component (500). The second end member component (600) includes a second component wall (602) with an outer surface portion (604). In some cases, the side wall portion (506) of the first component wall includes a plurality of first annular ribs (524) extending radially outward. The second component wall (602) includes a plurality of second annular ribs (612) extending radially inward. The pluralities of first and second annular ribs (524, 612) are axially interleaved with one another.

Abstract: The present invention provides multimers of one or more fusion proteins, each fusion protein including a Nrx-binding region of a Cblnl protein, a multimerization domain, and a AMPA receptor-binding region of a Nptxl protein, and pharmaceutical compositions containing the multimer(s) for use in forming new synaptic connections between excitatory interneurons.

Abstract: The present invention relates to the field of structural biology. More specifically, the present invention relates to an antigen-binding chimeric protein, called a MegaBody™, specifically binding a nanodisc, more specifically a membrane-scaffold protein (MSP)n which may be part of the nanodisc. The invention further provides for methods and uses of said nanodisc-specific antigen-binding chimeric proteins in three-dimensional high-resolution structural analysis of membrane proteins assembled within nanodiscs. The MSP-binding MegaBodies of the invention provide for a generic tool in membrane protein structural biology, more particular in Cryo-EM, by reducing preferred particle orientation of nanodiscs and of the entrapped target membrane proteins.

Abstract: Visualization of time series data includes sending to the data source a request for visualizing sensor data within a canvas having a width of w pixels and covering a visualization time range, each pixel of the canvas being representative of a time duration Iopt, receiving consecutive sets of tuples that each covers a time interval having the time duration It, performing a M4 aggregation comprising generating, from the received tuples, a set of consecutive w groups, each group of the w groups comprising tuples covering a time interval having the time duration Iopt, and determining for each group of the w groups a set of aggregates, and displaying the w sets of aggregates on the canvas of the browser window as a chart, wherein each one of the sets of aggregates is displayed in one of pixel columns of the canvas.

Abstract: Visualization of time series data includes sending to the data source a request for visualizing sensor data within a canvas having a width of w pixels and covering a visualization time range, each pixel of the canvas being representative of a time duration Iopt, receiving consecutive sets of tuples that each covers a time interval having the time duration It, performing a M4 aggregation comprising generating, from the received tuples, a set of consecutive w groups, each group of the w groups comprising tuples covering a time interval having the time duration Iopt, and determining for each group of the w groups a set of aggregates, and displaying the w sets of aggregates on the canvas of the browser window as a chart, wherein each one of the sets of aggregates is displayed in one of pixel columns of the canvas.

Abstract: The invention relates to methods of detecting the presence or absence of autoantibodies in an individual and to related methods and kits. In particular, the disclosure concerns measuring from one or more samples from an individual suspected of having a disease with an autoimmune component for binding of one or more autoantibodies to membrane vesicles comprising corresponding one or more antigens.

Abstract: Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase ? (RPTP?), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTP? and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTP?. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTP?. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

Abstract: The invention relates to methods of detecting the presence or absence of autoantibodies in an individual and to related methods and kits.

Abstract: After a predetermined limit for decryption attempts has been exceeded by a user attempting to decrypt an encrypted electronic message or attempting to decrypt a encrypted electronic certificate associated with an electronic message, access to the electronic message may be restricted.

Abstract: The invention relates to a process for determining an averaged frequency-dependent transfer function for a perturbed linear time-invariant system by means of an evaluation device, wherein the process comprises providing frequency-dependent reference signals derived from excitations input in a linear time-invariant system, providing frequency-dependent measuring signals for the linear time-invariant system associated with the frequency-dependent reference signals, and determining an averaged frequency-dependent transfer function for the linear time-invariant system, in that, using signal deconvolution of mutually associated measuring and reference signals, frequency-dependent transfer functions are determined and the frequency-dependent transfer functions are averaged, and wherein during determination of the averaged frequency-dependent transfer function at least a part of the determined frequency-dependent transfer functions is included in the averaging corresponding to a respectively associated frequency-dep

Abstract: Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase ? (RPTP?), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTP? and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTP?. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTP?. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

Abstract: Embodiments of the invention can relate to methods and devices for determining a room acoustic impulse response in a time domain. In one embodiment, an acoustic input signal from an acoustic signal source is emitted into an acoustic room, an acoustic output signal is detected by an acoustic measuring device in the room and fed from the acoustic measuring device to an evaluating device and, via the evaluating device, from a reference signal corresponding to the acoustic input signal, and the acoustic output signal, if necessary after prior processing of the acoustic output signal, a room acoustic impulse response in the time domain of the acoustic room is calculated in realtime and prepared for output in that, temporally in parallel and continuously, the acoustic input signal is emitted, the acoustic output signal is detected and, via the evaluating device, the room acoustic impulse response in the time domain is determined.

Abstract: The invention relates to a process for determining an averaged frequency-dependent transfer function for a perturbed linear time-invariant system by means of an evaluation device, wherein the process comprises providing frequency-dependent reference signals derived from excitations input in a linear time-invariant system, providing frequency-dependent measuring signals for the linear time-invariant system associated with the frequency-dependent reference signals, and determining an averaged frequency-dependent transfer function for the linear time-invariant system, in that, using signal deconvolution of mutually associated measuring and reference signals, frequency-dependent transfer functions are determined and the frequency-dependent transfer functions are averaged, and wherein during determination of the averaged frequency-dependent transfer function at least a part of the determined frequency-dependent transfer functions is included in the averaging corresponding to a respectively associated frequency-dep

Abstract: An apparatus and method for synthesizing nanostructures. In one embodiment, the apparatus includes a reactor having a reaction zone and a conductive susceptor positioned in the reaction zone. The method includes the steps of transporting a gas mixture having an aerosolized catalyst, a feedstock and a carrier gas into the reaction zone of the reactor, inductively heating the reaction zone, and regulating a flow rate of the gas mixture to allow the catalyst to spend a sufficient amount of time in the reaction zone for the growth of nanostructures.

Abstract: After a predetermined limit for decryption attempts has been exceeded by a user attempting to decrypt an encrypted electronic message or attempting to decrypt a encrypted electronic certificate associated with an electronic message, access to the electronic message may be restricted.

Abstract: Embodiments of the invention can relate to methods and devices for determining a room acoustic impulse response in a time domain. In one embodiment of a method, an acoustic input signal from an acoustic signal source is emitted into an acoustic room, an acoustic output signal is detected by an acoustic measuring device in the room and fed from the acoustic measuring device to an evaluating device and, by means of the evaluating device, from a reference signal corresponding to the acoustic input signal, and the acoustic output signal, if necessary after prior processing of the acoustic output signal, a room acoustic impulse response in the time domain of the acoustic room is calculated in real time and prepared for output in that, temporally in parallel and continuously, the acoustic input signal is emitted, the acoustic output signal is detected and, by means of the evaluating device, the room acoustic impulse response in the time domain is determined.

Abstract: An apparatus and method for synthesizing nanostructures. In one embodiment, the apparatus includes a reactor having a reaction zone and a conductive susceptor positioned in the reaction zone. The method includes the steps of transporting a gas mixture having an aerosolized catalyst, a feedstock and a carrier gas into the reaction zone of the reactor, inductively heating the reaction zone, and regulating a flow rate of the gas mixture to allow the catalyst to spend a sufficient amount of time in the reaction zone for the growth of nanostructures.

Abstract: An apparatus and method for synthesizing nanostructures. In one embodiment, the apparatus includes a reactor having a reaction zone and a conductive susceptor positioned in the reaction zone. The method includes the steps of transporting a gas mixture having an aerosolized catalyst, a feedstock and a carrier gas into the reaction zone of the reactor, inductively heating the reaction zone, and regulating a flow rate of the gas mixture to allow the catalyst to spend a sufficient amount of time in the reaction zone for the growth of nanostructures.

Abstract: An apparatus for synthesizing nanostructures. In one embodiment, the apparatus includes a heating device that defines a reaction zone therein and a susceptor made of a ferromagnetic material with a Curie temperature and placed in the reaction zone, where the Curie temperature substantially corresponds to a temperature at which the growth of desired nanostructures occurs and the heating device is capable of heating the susceptor substantially at the Curie temperature.

Abstract: An apparatus and method for synthesizing nanostructures. In one embodiment, the apparatus includes a reactor having a reaction zone and a conductive susceptor positioned in the reaction zone. The method includes the steps of transporting a gas mixture having an aerosolized catalyst, a feedstock and a carrier gas into the reaction zone of the reactor, inductively heating the reaction zone, and regulating a flow rate of the gas mixture to allow the catalyst to spend a sufficient amount of time in the reaction zone for the growth of nanostructures.