Patents by Inventor Alexei Brooun

Alexei Brooun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents
    Patent number: 10662204
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and administration of these compounds to patients to treat pancreatic, lung, colon and other cancers.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: May 26, 2020
    Assignee: Pfizer Inc.
    Inventors: Simon Planken, Hengmiao Cheng, Michael Raymond Collins, Jillian Elyse Spangler, Alexei Brooun, Andreas Maderna, Cynthia Palmer, Maria Angelica Linton, Asako Nagata, Ping Chen
  • Tetrahydroquinazoline derivatives useful as anticancer agents
    Patent number: 10590115
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: March 17, 2020
    Assignee: Pfizer Inc.
    Inventors: Simon Planken, Hengmiao Cheng, Michael Raymond Collins, Jillian Elyse Spangler, Alexei Brooun, Andreas Maderna, Cynthia Palmer, Maria Angelica Linton, Asako Nagata, Ping Chen
  • Tetrahydroquinazoline Derivatives Useful as Anticancer Agents
    Publication number: 20190248767
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Application
    Filed: February 1, 2019
    Publication date: August 15, 2019
    Applicant: PFIZER INC.
    Inventors: Simon PLANKEN, Hengmiao CHENG, Michael Raymond COLLINS, Jillian Elyse SPANGLER, Alexei BROOUN, Andreas MADERNA, Cynthia PALMER, Maria Angelica LINTON, Asako NAGATA, Ping CHEN
  • Substituted Quinazoline and Pyridopyrimidine Derivatives Useful as Anticancer Agents
    Publication number: 20190233440
    Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Applicant: PFIZER INC.
    Inventors: Simon PLANKEN, Hengmiao CHENG, Michael Raymond COLLINS, Jillian Elyse SPANGLER, Alexei BROOUN, Andreas MADERNA, Cynthia PALMER, Maria Angelica LINTON, Asako NAGATA, Ping CHEN
  • Crystalline composition of farsenyl pyrophosphate synthase (IspA)
    Patent number: 7563610
    Abstract: Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from E. coli and its various uses.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: July 21, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Douglas R. Dougan, David Hosfield, Yanming Zhang
  • Crystallization of the catalytic domain of human phosphodiesterase 4-D3 (PDE4-D3)
    Patent number: 7556950
    Abstract: Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: July 7, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Ellen Chien, Douglas R. Dougan, Michelle L. Kraus, Clifford D. Mol, Gyorgy Snell
  • Crystal of a Receptor-Ligand Complex and methods of use
    Publication number: 20080064052
    Abstract: The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the Receptor-Ligand Complex for identifying, designing, selecting, or testing inhibitors of the EphB4 receptor protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the receptor.
    Type: Application
    Filed: January 12, 2007
    Publication date: March 13, 2008
    Applicant: The Scripps Research Institute
    Inventors: Peter Kuhn, Anand Kolaktar, Alexei Brooun, Jill Chrencik, Michelle Kraus
  • Crystal Structure of a Receptor-Ligand Complex and Methods of Use
    Publication number: 20080020984
    Abstract: The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the Receptor-Ligand Complex for identifying, designing, selecting, or testing inhibitors of the EphB4 receptor protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the receptor.
    Type: Application
    Filed: July 23, 2007
    Publication date: January 24, 2008
    Applicant: The Scripps Research Institute
    Inventors: Peter Kuhn, Anand Kolatkar, Alexei Brooun, Jill Chrencik, Michelle Kraus
  • Crystallization of protein kinase B?/AKT1
    Patent number: 7309594
    Abstract: Provided are crystals relating to Protein kinase B?/AKT1 and its various uses.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: December 18, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Ellen Y. T. Chien, Douglas R. Dougan, Andrew J. Jennings, Michelle L. Kraus, Clifford D. Mol
  • Crystallization of MvaS (HMG-CoA Synthase)
    Patent number: 7252930
    Abstract: Provided are crystals relating to MvaS (HMG-CoA Synthase) and its various uses.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: August 7, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, David J. Hosfield, Robert J. Skene, Leslie W. Tari, Sheng Ye
  • Crystallization of Glucocorticoid Receptor
    Patent number: 7241868
    Abstract: Provided are crystals relating to human Glucocorticoid Receptor and its various uses.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: July 10, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Oleg Brodsky, Ellen Chien, Douglas R. Dougan, Clifford D. Mol, Gyorgy Snell
  • Crystal structure of MvaS
    Patent number: 7076372
    Abstract: Provided are structure coordinates relating to MvaS and its various uses.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: July 11, 2006
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, David J. Hosfield, Robert J. Skene, Leslie W. Tari, Sheng Ye