Patents by Inventor Alexei Korennykh

Alexei Korennykh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of monitoring RNase L activity
    Patent number: 11859234
    Abstract: The present disclosure relates, in general, to a method for generating chimeric DNA derived from RNase L cleavage products in a sample, and detection of such RNase L cleavage products for diagnosis and treatment of inflammation and infection in a subject.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: January 2, 2024
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Alexei Korennykh, Jesse Donovan
  • Reporter construct and biosensor for interferon second messenger 2-5A
    Patent number: 11667949
    Abstract: The present disclosure relates, in general, to a fusion protein construct comprising RNase L and a split reporter system, and methods of using the reporter for detecting 2?-5? linked oligoadenylates (2-5A) and double stranded RNA in vivo.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: June 6, 2023
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Alexei Korennykh, Alisha Chitrakar, Jesse Donovan
  • Compositions Comprising Immune System Activators and Method of Using Same
    Publication number: 20210047646
    Abstract: The present invention relates, in various embodiments, to compositions comprising synthetic DNA molecules, and methods of using such compositions to enhance an immune response to cancer, for example, by activating the RNase L pathway in cells without inducing immunosuppressive effects caused by other agents that are known to activate this pathway.
    Type: Application
    Filed: April 9, 2019
    Publication date: February 18, 2021
    Inventors: Alisha Chitrakar, Alexei Korennykh
  • Reporter Construct and Biosensor for Interferon Second Messenger 2-5A
    Publication number: 20190249223
    Abstract: The present disclosure relates, in general, to a fusion protein construct comprising RNase L and a split reporter system, and methods of using the reporter for detecting 2?-5? linked oligoadenylates (2-5A) and double stranded RNA in vivo.
    Type: Application
    Filed: February 15, 2019
    Publication date: August 15, 2019
    Inventors: Alexei Korennykh, Alisha Chitrakar, Jesse Donovan
  • METHOD OF MONITORING RNASE L ACTIVITY
    Publication number: 20190203259
    Abstract: The present disclosure relates, in general, to a method for generating chimeric DNA derived from RNase L cleavage products in a sample, and detection of such RNase L cleavage products for diagnosis and treatment of inflammation and infection in a subject.
    Type: Application
    Filed: May 5, 2017
    Publication date: July 4, 2019
    Inventors: Alexei Korennykh, Jesse Donovan
  • Methods and compositions for modulating Ire1, SRC and ABL activity
    Patent number: 9382230
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: July 5, 2016
    Assignee: The Regents of the University of California
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales
  • Methods of inhibiting Ire1
    Patent number: 8980899
    Abstract: Disclosed herein are, inter alia, methods for inhibiting Ire1 activity.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: March 17, 2015
    Assignee: The Regents of the University of California
    Inventors: Alexei Korennykh, Peter Walter, Han Li, Arvin Dar, Kevan Shokat
  • METHODS AND COMPOSITIONS FOR MODULATING IRE1, SRC, AND ABL ACTIVITY
    Publication number: 20150011575
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales
  • Methods and compositions for modulating IRE1, SRC, and ABL activity
    Patent number: 8815885
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: August 26, 2014
    Assignee: The Regents of the University of California
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales
  • METHODS OF INHIBITING IRE1
    Publication number: 20120322814
    Abstract: Disclosed herein are, inter alia, methods for inhibiting Ire1 activity.
    Type: Application
    Filed: October 18, 2010
    Publication date: December 20, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alexei Korennykh, Peter Walter, Han Li, Arvin Dar, Kevan Shokat
  • Methods and Compositions for Modulating IRE1, SRC, and ABL Activity
    Publication number: 20110319436
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Application
    Filed: September 15, 2009
    Publication date: December 29, 2011
    Applicant: The Regents of the University of California
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales