Abstract: The invention relates to methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of an inhibitor of the interaction between the PD-1 receptor and its ligand PD-L1.

Abstract: The present invention is a microscope slide holder suitable for use with a centrifuge. The slide holder includes a base with a plurality of chambers, the chambers being formed to receive and retain microscope slides. The slide holder may also include a seal, configured to cover the plurality of chambers, and a lid, which is removable from the base. The slide holder may also include a cover, which is configured to cover selected portions of the microscope slide. The method of using the microscope slide holder is also disclosed.

Abstract: The closed electron drift plasma accelerator comprises an annular ionization chamber, an acceleration chamber on the same axis as the ionization chamber, an annular anode, a hollow cathode, a first DC voltage source, an annular gas manifold, a magnetic circuit, and magnetic field generators. A coaxial annular coil is placed in the cavity of the ionization chamber, is provided with bias conductive cladding connected, together with the electrically-conductive material of the inside faces of the walls of the ionization chamber, to the positive pole of a second voltage source whose negative pole is connected to the anode, and constitutes an additional magnetic field generator which, together with the other magnetic field generators, forms a magnetic field having a magnetic line of force with an “X” point corresponding to a magnetic field zero situated between the coaxial annular coil and the anode.

Abstract: The present invention relates to a manipulating device (A) for producing Schönflies motions comprising a parallel array of at least two legs (B), each leg (B) including an actuator unit (C) having first and second ends and producing a pan-tilt motion, each leg (B) also including a passive unit (D) having first and second ends, the first end of the passive unit (D) being coupled to the first end of the actuator unit (C) such that the passive unit (D) reacts to the pan-tilt motion, a base (1) connected to the second end of each actuator unit (C), all second ends having a constant relative position with respect to one another; and a common end-effector (36) connected to the second end of all passive units (D) such that the common end-effector (36) is provided with a Schönflies motion by the legs (B).

Abstract: The present invention relates to a manipulating device (A) for producing Schönflies motions comprising a parallel array of at least two legs (B), each leg (B) including an actuator unit (C) having first and second ends and producing a pan-tilt motion, each leg (B) also including a passive unit (D) having first and second ends, the first end of the passive unit (D) being coupled to the first end of the actuator unit (C) such that the passive unit (D) reacts to the pan-tilt motion, a base (1) connected to the second end of each actuator unit (C), all second ends having a constant relative position with respect to one another; and a common end-effector (36) connected to the second end of all passive units (D) such that the common end-effector (36) is provided with a Schönflies motion by the legs (B).

Abstract: The closed electron drift plasma accelerator comprises an annular ionization chamber, an acceleration chamber on the same axis as the ionization chamber, an annular anode, a hollow cathode, a first DC voltage source, an annular gas manifold, a magnetic circuit, and magnetic field generators. A coaxial annular coil is placed in the cavity of the ionization chamber, is provided with bias conductive cladding connected, together with the electrically-conductive material of the inside faces of the walls of the ionization chamber, to the positive pole of a second voltage source whose negative pole is connected to the anode, and constitutes an additional magnetic field generator which, together with the other magnetic field generators, forms a magnetic field having a magnetic line of force with an “X” point corresponding to a magnetic field zero situated between the coaxial annular coil and the anode.

Abstract: A device for measuring variations in the thrust of a plasma accelerator with closed electron drift comprising a main annular channel for ionization and acceleration, at least one hollow cathode disposed outside the main channel and downstream therefrom, an anode, ionizable gas feed means associated respectively with the hollow cathode and with the anode, and magnetic field creation means. The device comprises a plurality of magnetic flux sensors (101 to 104; 31 to 33) disposed around the acceleration channel (24), a plurality of amplifiers (111 to 114) whose inputs receive the respective signals delivered by the magnetic flux sensors (101 to 104; 31 to 33) and a summing circuit (115) whose inputs are connected to the outputs of said amplifiers (111 to 114).

Abstract: The system (31 to 33, 34 to 38) for generating a magnetic field in the main channel of the plasma accelerator are adapted to produce, in the main channel (24) an essentially radial magnetic field at the downstream end (225) of the channel (24), its induction being maximum at this point. The magnetic field has a minimum induction in the transition area in the vicinity of the anode (25), the absolute induction value of the field increasing again upstream of the anode (25), in the region of the buffer chamber (23) in order to produce a magnetic mirror effect. The magnetic field lines include, between the anode (25) and the downstream end (225) of the channel (24), a concavity oriented downstream, causing focusing of ions, the maximum ionisation density area being located downstream of the anode (25).