Patents by Inventor Alexei Prokhnevsky

Alexei Prokhnevsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof
    Patent number: 9364530
    Abstract: The present invention relates to novel virus-like particles (VLPs) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus. The target polypeptide may be antigenic or therapeutic. The first and the second plant enveloped viruses may be the same. Either plant enveloped virus may be a plant rhabdovirus. Also provided are methods of making and using the VLPs.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 14, 2016
    Assignee: Fraunhofer USA, Inc.
    Inventors: Alexei Prokhnevsky, Vidadi Yusibov
  • VIRUS-LIKE PARTICLES COMPRISING A MATRIX PROTEIN FROM A PLANT ENVELOPED VIRUS AND USES THEREOF
    Publication number: 20150086589
    Abstract: The present invention relates to novel virus-like particles (VLPs) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus. The target polypeptide may be antigenic or therapeutic. The first and the second plant enveloped viruses may be the same. Either plant enveloped virus may be a plant rhabdovirus. Also provided are methods of making and using the VLPs.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 26, 2015
    Applicant: FRAUNHOFER USA Inc.
    Inventors: Alexei Prokhnevsky, Vidadi Yusibov
  • CLOSTEROVIRUS-BASED NUCLEIC ACID MOLECULES AND USES THEREOF
    Publication number: 20140056908
    Abstract: The present invention relates to novel nucleic acid molecules for producing target polypeptides in plant cells. More specifically, the novel nucleic acid molecules comprise a minireplicon derived from a Closteroviridae virus and heterologous polynucleotides encoding the target polypeptides. Also provided are compositions comprising the target polypeptides and uses thereof.
    Type: Application
    Filed: October 7, 2011
    Publication date: February 27, 2014
    Applicant: FRAUNHOFER USA INC.
    Inventors: Alexei Prokhnevsky, Vidadi Yusibov, Vadim Mett