Patents by Inventor Alexei V. Babkin
Alexei V. Babkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12161382Abstract: An ablation apparatus for creating a lesion in target tissue has a handle, an elongate shaft extending from the handle and a distal ablation portion. The distal ablation portion includes a cryogen flow manifold defining a plurality of fluid pathways between an insert body and a sleeve. Cryogen is circulated through the plurality of fluid pathways to create the lesion in the target tissue.Type: GrantFiled: July 27, 2021Date of Patent: December 10, 2024Assignee: Adagio Medical, Inc.Inventors: Cuong Pham, Kevin D. Rupp, Alexei V. Babkin, Pedram Nourian, Thu Tran, Steven W. Kovalcheck
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Publication number: 20240238028Abstract: A method of reducing visceral fat in the body of a patient comprises thermally treating the visceral fat sufficient to form a liquid-fat mixture or emulsion. The liquid-fat emulsion is then aspirated. Thermally treating can be performed by cooling according to a temperature profile causing the cell membranes to be disrupted. The visceral fat cells are warmed with a warming liquid immediately following cooling. The warming liquid, along with the contents of the fat cells that mix with the warming liquid, are withdrawn by aspiration.Type: ApplicationFiled: May 23, 2022Publication date: July 18, 2024Applicant: B2M MEDICAL, INC.Inventors: Meital MAZOR, Alexei V. Babkin, Rafi MAZOR
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Publication number: 20240122637Abstract: A surgical method for reducing insulin resistance comprises cryolipolysis of mesenteric fat in a controlled manner to avoid tissue ablative temperatures. Cryolipolysis is carried out in stages based on evaluating reduction in volumes of mesenteric fat and fasting glucose levels.Type: ApplicationFiled: October 12, 2023Publication date: April 18, 2024Inventors: Rafi MAZOR, Alexei V. Babkin
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Publication number: 20240122636Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.Type: ApplicationFiled: December 19, 2023Publication date: April 18, 2024Inventors: Alexei V. Babkin, Steven W. Kovalcheck, Xiaoyu Yu
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Publication number: 20240058047Abstract: A multimodality or hybrid ablation system includes an ablation apparatus for creating a lesion in target tissue. The ablation apparatus has an ablation shaft including a handle, a first portion, an ablation portion, distal tip, at least one ablation energy delivery lumen, at least one ablation energy return lumen, and a stylet lumen that extends substantially along a length of the ablation shaft from the handle to at least the ablation portion. The ablation apparatus also includes a stylet that is capable of being inserted into the stylet lumen where the stylet is made of a shape-memory material. A plurality of electrodes are arranged on the ablation portion for measuring or verifying tissue contact with the tissue and applying a pulsed electric field. Optionally, the pulsed electric field may be applied after or in parallel with freezing the target tissue.Type: ApplicationFiled: March 25, 2021Publication date: February 22, 2024Applicant: ADAGIO MEDICAL, INC.Inventors: Alexei V. BABKIN, Shirzad SHAHRIARI, Hou Man CHONG, Pedram NOURIAN, Faysal S. AHMED, Kevin D. RUPP
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Patent number: 11883085Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.Type: GrantFiled: October 22, 2021Date of Patent: January 30, 2024Assignee: Adagio Medical, Inc.Inventors: Alexei V. Babkin, Steven W. Kovalcheck, Xiaoyu Yu
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Patent number: 11751930Abstract: An ablation apparatus for creating a lesion in target tissue, the ablation apparatus including a handle, an elongate shaft extending from the handle to a distal tip, where the shaft includes a first portion, an ablation portion distal to the first portion and having an outer sheath, and at least one ablation energy element disposed within the outer sheath, where a space is formed between the at least one ablation energy element and the outer sheath. The ablation apparatus further includes a thermally conductive liner disposed within the space.Type: GrantFiled: January 8, 2019Date of Patent: September 12, 2023Assignee: ADAGIO MEDICAL, INC.Inventors: Alexei V. Babkin, Thomas Chien, Kevin D. Rupp, Steven W. Kovalcheck
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Publication number: 20230046154Abstract: Embodiments described herein are directed to a system for providing alternating freeze and thaw cycles. The system includes a controller, a vessel for holding a working fluid, a pressure generator, a cooler, a cooler heat exchanger, a heater, a heater heat exchanger, a check valve, and a treatment instrument. In some embodiments, the treatment instrument includes a distal end, a proximal end, a connecting portion adjacent to the proximal end, a needle element adjacent the distal end, a handle portion disposed between the proximal and distal end, and a depth-limiting element to limit an injection depth of the needle element.Type: ApplicationFiled: October 14, 2022Publication date: February 16, 2023Inventors: Meital Mazor, Alexei V. Babkin
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Patent number: 11517365Abstract: Embodiments described herein are directed to a system for providing alternating freeze and thaw cycles. The system includes a controller, a vessel for holding a working fluid, a pressure generator, a cooler, a cooler heat exchanger, a heater, a heater heat exchanger, a check valve, and a treatment instrument. In some embodiments, the treatment instrument includes a distal end, a proximal end, a connecting portion adjacent to the proximal end, a needle element adjacent the distal end, a handle portion disposed between the proximal and distal end, and a depth-limiting element to limit an injection depth of the needle element.Type: GrantFiled: February 3, 2017Date of Patent: December 6, 2022Inventors: Meital Mazor, Alexei V. Babkin
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Publication number: 20220160413Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.Type: ApplicationFiled: October 22, 2021Publication date: May 26, 2022Inventors: Alexei V. Babkin, Steven W. Kovalcheck, Xiaoyu Yu
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Publication number: 20220071680Abstract: An ablation apparatus for creating a lesion in target tissue has a handle, an elongate shaft extending from the handle and a distal ablation portion. The distal ablation portion includes a cryogen flow manifold defining a plurality of fluid pathways between an insert body and a sleeve. Cryogen is circulated through the plurality of fluid pathways to create the lesion in the target tissue.Type: ApplicationFiled: July 27, 2021Publication date: March 10, 2022Inventors: Cuong Pham, Kevin D. Rupp, Alexei V. Babkin, Pedram Nourian, Thu Tran, Steven W. Kovalcheck
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Publication number: 20220071681Abstract: A multimodality or hybrid ablation system includes an ablation apparatus for creating a lesion in target tissue. The ablation apparatus has an ablation shaft including a handle, a first portion, an ablation portion, distal tip, at least one ablation energy delivery lumen, at least one ablation energy return lumen, and a stylet lumen that extends substantially along a length of the ablation shaft from the handle to at least the ablation portion. The ablation apparatus also includes a stylet that is capable of being inserted into the stylet lumen where the stylet is made of a shape-memory material. A plurality of electrodes are arranged on the ablation portion for measuring or verifying tissue contact with the tissue and applying a pulsed electric field. Optionally, the pulsed electric field may be applied after, contemporaneously, or for only a portion that the cryo-modality is applied to the target tissue.Type: ApplicationFiled: September 29, 2021Publication date: March 10, 2022Inventors: Kevin D. Rupp, Alexei V. Babkin, Shirzad Shahriari, Hou Man Chong, Pedram Nourian, Faysal S. Ahmed
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Patent number: 11197707Abstract: A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.Type: GrantFiled: December 20, 2018Date of Patent: December 14, 2021Assignee: ADAGIO MEDICAL, INC.Inventors: Peter J. Littrup, Alexei V. Babkin, Robert V. Duncan, Pramod Kerkar, Sergey T. Boldarev
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Patent number: 11179186Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.Type: GrantFiled: April 25, 2020Date of Patent: November 23, 2021Assignee: Adagio Medical, Inc.Inventors: Alexei V. Babkin, Steven W. Kovalcheck, Xiaoyu Yu
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Publication number: 20210315627Abstract: A cryoablation apparatus for creating a lesion in a target tissue includes an expandable energy transfer region formed of a plurality of independent spline ablation members. Manipulation of a control member extending from a handle to the energy transfer region controllably adjusts the shape of the energy transfer region to contact complex anatomies. A service lumen extending through the length of apparatus can slidably receive an ancillary catheter such as a guide catheter or diagnostic catheter. The catheter has particular application to treating conditions of the heart. Related methods and systems are also described.Type: ApplicationFiled: July 29, 2019Publication date: October 14, 2021Applicant: ADAGIO MEDICAL, INC.Inventors: Alexei V. BABKIN, David CABRITA
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Patent number: 10952676Abstract: An endoesophageal balloon and catheter for operation with a transesophageal echocardiography (TEE) probe includes an inflatable balloon body disposed over the ultrasound element of the TEE probe, a liquid inflow lumen in fluid communication with the balloon, and a liquid outflow lumen in fluid communication with the balloon. The balloon is inflated with an acoustically transmitting liquid.Type: GrantFiled: October 12, 2014Date of Patent: March 23, 2021Assignee: Adagio Medical, Inc.Inventors: Alexei V. Babkin, Peter Littrup, Steven W. Kovalcheck
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Publication number: 20210059737Abstract: An ablation apparatus for creating a lesion in target tissue, the ablation apparatus including a handle, an elongate shaft extending from the handle to a distal tip, where the shaft includes a first portion, an ablation portion distal to the first portion and having an outer sheath, and at least one ablation energy element disposed within the outer sheath, where a space is formed between the at least one ablation energy element and the outer sheath. The ablation apparatus further includes a thermally conductive liner disposed within the space.Type: ApplicationFiled: January 8, 2019Publication date: March 4, 2021Applicant: ADAGIO MEDICAL, INC.Inventors: Alexei V. BABKIN, Thomas CHIEN, Kevin D. RUPP, Steven W. KOVALCHECK
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Publication number: 20200261136Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.Type: ApplicationFiled: April 25, 2020Publication date: August 20, 2020Applicant: Adagio Medical, Inc.Inventors: Alexei V. Babkin, Steven W. Kovalcheck, Xiaoyu Yu
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Patent number: 10667854Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.Type: GrantFiled: September 22, 2014Date of Patent: June 2, 2020Assignee: Adagio Medical, Inc.Inventors: Alexei V. Babkin, Steven W. Kovalcheck, Xiaoyu Yu
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Publication number: 20190117288Abstract: A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.Type: ApplicationFiled: December 20, 2018Publication date: April 25, 2019Applicant: ADAGIO MEDICAL, INC.Inventors: PETER J. LITTRUP, ALEXEI V. BABKIN, ROBERT V. DUNCAN, PRAMOD KERKAR, SERGEY T. BOLDAREV