Abstract: A multi-mode PLL frequency synthesizer of a wireless multi-mode transceiver is provided which includes a reference frequency source providing an oscillator signal with a constant reference frequency, a first frequency synthesizer subunit for converting the signal into carrier signals with frequencies in the range of a first frequency band, a second frequency synthesizer subunit for transforming the oscillator signal into carrier signals having frequencies in the range of a second frequency band, and a third frequency synthesizer subunit for converting the oscillator signal into an auxiliary signal with a fixed frequency. The auxiliary signal is used together with the carrier signals of the second frequency band to generate carrier signals with frequencies in the range of a third and fourth frequency band.

Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.

Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.

Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.

Abstract: A multi-mode PLL frequency synthesizer of a wireless multi-mode transceiver is provided which includes a reference frequency source providing an oscillator signal with a constant reference frequency, a first frequency synthesizer subunit for converting the signal into carrier signals with frequencies in the range of a first frequency band, a second frequency synthesizer subunit for transforming the oscillator signal into carrier signals having frequencies in the range of a second frequency band, and a third frequency synthesizer subunit for converting the oscillator signal into an auxiliary signal with a fixed frequency. The auxiliary signal is used together with the carrier signals of the second frequency band to generate carrier signals with frequencies in the range of a third and fourth frequency band.