Abstract: The present invention relates to methods and systems for brain sex phenotype score prediction according to application of artificial intelligence algorithms to scalp electroencephalography data. Whether male- or female-born, each person does not necessarily abide by biologically predetermined sex for the brain. The human brain is sexually dimorphic, which matters when a decision on mental health and treatment selection is made. A brain sex phenotype score is introduced to address the need to measure the current brain sex. The score estimation method relies on the deep learning algorithm that integrates the feature extraction and classification processes into a single automated architecture. The method uses novel algorithms for scalp electroencephalogram data augmentation and channel rolling, allowing the claimed network to be more precise and converge faster. A SAAS-based framework for brain sex phenotype score calculation is disclosed in one or more embodiments.

Abstract: A power conversion system comprising an electric machine and at least two power electronics converters, wherein the electrical machine comprises at least one current carrying component, wherein the current carrying component consists of at least two concentric rings forming the current carrying component. The at least two concentric rings are not galvanically or electrically connected to each other and each concentric ring is galvanically connected to at least one power converter via its machine side terminals.

Abstract: The invention relates to an electrical machine for submerged applications and an energy conversion system for conversion of mechanical energy of unidirectional or reciprocating linear or rotational motion into electric energy and vice versa. The electric energy may be in the form of DC or AC current and voltage. The system is totally submerged in pure or salt water. The enabling element of the invention is multi-pole permanent magnet synchronous machine with separately encapsulated stator and rotor, integrated with mechanical system and power electronics.

Abstract: A method of preparing the anthracyclin carminomycin using a starting material comprising daunorubicin. The method comprises reacting daunorubicin or N-protected daunorubicin with soft Lewis acids for the demethylation of the 4-methoxy group, resulting in a reaction mass. The reaction mass is treated with an aqueous solution of a strong organic acid or a mineral acid. After decomposition of the resulting carminomycin and Lewis acids reactive complex, the reaction mass is extracted using a water insoluble organic solvent. As a result, carminomycin is extracted as a base.

Abstract: Complete drive system, called motor-drive unit, for use in remote locations with limited radial space like downhole, narrow tunnels, pipelines and other applications with similar conditions. Given the spatial limitations the unit must have elongated shape. It includes a number of motors connected mechanically in series and a lower number of inverters, driving groups of the motors so that load is equally distributed along axis of the unit. Motors within each group can be electrically connected in series or in parallel. The motor-drive unit is supposed to be fed by DC voltage via a cable with length up to several km; therefore, it includes a buck converter for stabilization of voltage inside the unit and a power-line communication module to be controllable from the surface.

Abstract: A method of preparing an anthracyclin such as epirubicin from a starting material comprising 13-dihydrodaunorubicine (13-daunorubicinol). The method comprises producing N-Trifluoroacetyl-13-daunorubicinol from 13-daunorubicinol by acylation. The N-Trifluoroacetyl-13-daunorubicinol is reacted with an aprotic solvent and an acylating agent to produce an intermediate sulfoxy salt which is treated with a strong base to produce 4?-keto-N-Trifluoroacetyldaunorubicin. The 4?-keto-N-Trifluoroacetyldaunorubicin is reacted with a reducing agent, such as borohydride of an alkaline metal, to produce N-Trifluoroacetyl-4?-epi-daunorubicin. The N-Trifluoroacetyl-4?-epi-daunorubicin is hydrolyzed in a basic solution to produce an intermediate compound. The intermediate compound is reacted with a halogenizing agent to produce a 14-Hal-derivative. The 14-Hal derivative is hydrolized in the presence of a formate of an alkaline metal to produce the desired final compound.

Abstract: The invention relates to an electrical machine for submerged applications and an energy conversion system for conversion of mechanical energy of unidirectional or reciprocating linear or rotational motion into electric energy and vice versa. The electric energy may be in the form of DC or AC current and voltage. The system is totally submerged in pure or salt water. The enabling element of the invention is multi-pole permanent magnet synchronous machine with separately encapsulated stator and rotor, integrated with mechanical system and power electronics.

Abstract: A method for the aralkylation of anthracyclins by utilizing an aralkylating agent R3—CH2X (for example, BnBr) in accordance with the reaction pathway describe by the scheme shown in FIG. 1. The present invention recognizes that 4-R1, 3?-N3-Daunomycines are suitable substrates for selective 4?-O-benzylation, yielding 4-R1, 3?-N3-4?-O-Aralkyl-Daunorubicines (in particular, 4?-O-Bn-Daunomycines). Thus, the present invention provides a pathway for a simple production of 4?-O-aralkylated derivatives of anthracyclines which can be effectively used to produce anthracyclines.

Abstract: The purpose is to accommodate large axial channels in a slim electric machine without sacrificing its torque density and radial dimensions. This is possible with a rotor (11) provided with permanent magnets (12) and a stator (13) with slots (15) for coils (20A-c), where the slots (15) are separated by teeth (16, 17), which electrical machine include teeth (17) not carrying coils (20A-c), which teeth (17) are provided with axial channels (18, 18?) protruding into the teeth (17) and neighboring back iron so that an area of the channel (18, 18?) inside the tooth (17) is comparable to or even larger than the an area of the channel (18, 18?) in the back iron. The channels serve for transportation of fluids and other substances through the machine and also to integrate a motor protector, which may be required in down-hole applications. There are also novel manufacturing techniques associated with the new concept.

Abstract: Complete drive system, called motor-drive unit, for use in remote locations with limited radial space like downhole, narrow tunnels, pipelines and other applications with similar conditions. Given the spatial limitations the unit must have elongated shape. It includes a number of motors connected mechanically in series and a lower number of inverters, driving groups of the motors so that load is equally distributed along axis of the unit. Motors within each group can be electrically connected in series or in parallel. The motor-drive unit is supposed to be fed by DC voltage via a cable with length up to several km; therefore, it includes a buck converter for stabilization of voltage inside the unit and a power-line communication module to be controllable from the surface.

Abstract: A method for operating a doubly fed permanent magnet synchronous machine and a system including such a machine and a converter for feeding and withdrawal of power. The machine has two or more winding groups where at least one winding group is connected directly to a grid and at least one winding group has the possibility to be connected to the grid via a power electronics converter or directly.

Abstract: A method for the aralkylation of anthracyclins by utilizing an aralkylating agent R3-CH2X (for example, BnBr) in accordance with the reaction pathway describe by the scheme shown in FIG. 1. The present invention recognizes that 4-R1, 3?-N3-Daunomycines are suitable substrates for selective 4?-O-benzylation, yielding 4-R1, 3?-N3-4?-O-Aralkyl-Daunorubicines (in particular, 4?-O-Bn-Daunomycines). Thus, the present invention provides a pathway for a simple production of 4?-O-aralkylated derivatives of anthracyclines which can be effectively used to produce anthracyclines.

Abstract: A method of preparing an anthracyclin such as epirubicin from a starting material comprising 13-dihydrodaunorubicine (13-daunorubicinol). The method comprises producing N-Trifluoroacetyl-13-daunorubicinol from 13-daunorubicinol by acylation. The N-Trifluoroacetyl-13-daunorubicinol is reacted with an aprotic solvent and an acylating agent to produce an intermediate sulfoxy salt which is treated with a strong base to produce 4?-keto-N-Trifluoroacetyldaunorubicin. The 4?-keto-N-Trifluoroacetyldaunorubicin is reacted with a reducing agent, such as borohydride of an alkaline metal, to produce N-Trifluoroacetyl-4?-epi-daunorubicin. The N-Trifluoroacetyl-4?-epi-daunorubicin is hydrolyzed in a basic solution to produce an intermediate compound. The intermediate compound is reacted with a halogenizing agent to produce a 14-Hal-derivative. The 14-Hal derivative is hydrolized in the presence of a formate of an alkaline metal to produce the desired final compound.

Abstract: A method of preparing the anthracyclin carminomycin using a starting material comprising daunorubicin. The method comprises reacting daunorubicin or N-protected daunorubicin with soft Lewis acids for the demethylation of the 4-methoxy group, resulting in a reaction mass. The reaction mass is treated with an aqueous solution of a strong organic acid or a mineral acid. After decomposition of the resulting carminomycin and Lewis acids reactive complex, the reaction mass is extracted using a water insoluble organic solvent. As a result, carminomycin is extracted as a base.