Patents by Inventor Alexey Rivkin

Alexey Rivkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TYROSINE KINASE INHIBITORS
    Publication number: 20120264735
    Abstract: The present invention relates to pyridazin-4(1H)-one derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: December 14, 2010
    Publication date: October 18, 2012
    Inventors: Jonathan Young, Barbara Czako, Michael Altman, David Guerin, Michelle Martinez, Alexey Rivkin, Kevin Wilson, Kathryn Lipford, Catherine White, Laura Surdi, Stephanie Chichetti, Matthew H. Daniels, Sean P. Ahearn, Danielle Falcone, Ekundayo Osimboni
  • Piperidine derivatives
    Patent number: 8252803
    Abstract: Compounds of formula I: I selectively inhibit production of Ab(1-42) and hence find use in treatment of Alzheimer's disease and other conditions associated with deposition of A(b) in the brain.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: August 28, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Alexey A. Rivkin
  • Therapeutic agents
    Patent number: 8183276
    Abstract: The invention encompasses 2-[4-(imidazolyl)-phenyl]vinyl-heterocycle derivatives which selectively attenuate production of Abeta(1-42) and are useful in the treatment of Alzheimer's disease. Pharmaceutical compositions and methods of use are also encompassed.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: May 22, 2012
    Inventors: Christian Fischer, Benito Munoz, Alexey A. Rivkin
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 8110590
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: February 7, 2012
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20120022044
    Abstract: According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of A?42 and hence are useful in treatment of Alzheimer's disease and related conditions.
    Type: Application
    Filed: December 7, 2009
    Publication date: January 26, 2012
    Inventors: Christian Fischer, Joey Methot, Hua Zhou, Adam J. Schell, Benito Munoz, Alexey A. Rivkin, Sean P. Ahearn, Stephanie Chichetti, Rachel N. MacCoss, Sam Kattar, Matthew Christopher, Chaomin Li, Andrew Rosenau, William Colby Brown
  • PURINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20110251172
    Abstract: The invention encompasses purine derivatives as gamma secretase modulators, useful for treating diseases associated with the deposition of beta-amyloid peptide in the brain, such as Alzheimer's disease, or of preventing or delaying the onset of dementia associated with such diseases. Pharmaceutical compositions and methods of use are included.
    Type: Application
    Filed: July 31, 2009
    Publication date: October 13, 2011
    Inventors: Alexey A. Rivkin, Sean P. Ahearn, Stephanie M. Chichetti, Christohpher L. Hamblett, Yudith Garcia, Michelle Martinez, Benito Munoz
  • PYRIMIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20110207733
    Abstract: The invention encompasses pyrimidine derivatives as gamma secretase modulators, useful for treating diseases associated with the deposition of beta-amyloid peptide in the brain, such as Alzheimer's disease, or of preventing or delaying the onset of dementia associated with such diseases. Pharmaceutical compositions and methods of use are included.
    Type: Application
    Filed: July 31, 2009
    Publication date: August 25, 2011
    Inventors: Alexey A. Rivkin, Sean P. Ahearn, Stephanie M. Chichetti
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 7875638
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: January 25, 2011
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong, Kaida Wu, Malcolm A. S. Moore, David Dorn
  • THERAPEUTIC AGENTS
    Publication number: 20100324029
    Abstract: The invention encompasses 2-[4-(imidazolyl)-phenyl]vinyl-heterocycle derivatives which selectively attenuate production of Abeta(1-42) and are useful in the treatment of Alzheimer's disease. Pharmaceutical compositions and methods of use are also encompassed.
    Type: Application
    Filed: February 5, 2008
    Publication date: December 23, 2010
    Inventors: Christian Fischer, Benito Munoz, Alexey A. Rivkin
  • PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS
    Publication number: 20100204230
    Abstract: Compounds of formula (I) selectively inhibit production of A?(1-42) and hence find use in treatment of Alzheimer's disease and other conditions associated with deposition of A(?) in the brain.
    Type: Application
    Filed: February 11, 2008
    Publication date: August 12, 2010
    Inventors: Peter Blurton, Stephen Fletcher, Martin Teall, Timothy Harrison, Benito Munoz, Alexey Rivkin, Christopher Hamblett, Phieng Siliphaivanh, Karin Otte
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF
    Publication number: 20100197746
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: October 22, 2009
    Publication date: August 5, 2010
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 7759374
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: July 20, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • PIPERIDINE DERIVATIVES
    Publication number: 20100041680
    Abstract: Compounds of formula I: I selectively inhibit production of Ab(1-42) and hence find use in treatment of Alzheimer's disease and other conditions associated with deposition of A(b) in the brain.
    Type: Application
    Filed: February 8, 2008
    Publication date: February 18, 2010
    Inventor: Alexey A. Rivkin
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Patent number: 7649006
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: January 19, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
  • Synthesis of Epothilones, Intermediates Thereto, Analogues and Uses Thereof
    Publication number: 20090149516
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: June 9, 2008
    Publication date: June 11, 2009
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong, Kaida Wu, Malcolm A.S. Moore, David Dorn
  • Inhibitors of Fatty Acid Synthase (Fas)
    Publication number: 20090048276
    Abstract: The instant invention provides for compounds which comprise substituted 3-aryl-4-hydroxyquinolin-2(1H)-ones that inhibit FAS activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting FAS activity by administering the compound to a patient in need of treatment of cancer.
    Type: Application
    Filed: January 26, 2007
    Publication date: February 19, 2009
    Inventors: Mark T. Goulet, Benito Munoz, Alexey A. Rivkin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 7384964
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: June 10, 2008
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong, Kaida Wu, Malcolm A. S. Moore, David Dorn
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Publication number: 20070032534
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: October 12, 2006
    Publication date: February 8, 2007
    Inventors: Samuel Danishefsky, Alexey Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana Gabarda, Huajin Dong
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Publication number: 20050143429
    Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
    Type: Application
    Filed: August 18, 2004
    Publication date: June 30, 2005
    Inventors: Samuel Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana Gabarda, Huajin Dong, Kaida Wu, Malcolm Moore, David Dorn
  • Synthesis of epothilones, intermediates thereto and analogues thereof
    Publication number: 20040053995
    Abstract: The present invention provides compounds of formula (I): 1
    Type: Application
    Filed: March 28, 2003
    Publication date: March 18, 2004
    Inventors: Samuel J. Danishefsky, Alexey Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda