Patents by Inventor Alexey Vyacheslavovich Stepanov

Alexey Vyacheslavovich Stepanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION OF DEOXYRIBONUCLEASE ENZYME AND CELL THERAPIES FOR TREATMENT OF CANCER
    Publication number: 20240050476
    Abstract: The invention relates to methods for treatment of cancers utilizing a combination of a deoxyribonuclease enzyme and adoptive cell immunotherapy comprising cells expressing a chimeric antigen receptor (CAR) or a T cell receptor (TCR). In particular embodiments, the deoxyribonuclease enzyme can be given parenterally or encoded by a vector or secreted by a cell comprising TCR or CAR.
    Type: Application
    Filed: January 7, 2022
    Publication date: February 15, 2024
    Applicant: CLS THERAPEUTICS LIMITED
    Inventors: Dmitry Dmitrievich GENKIN, Georgy Viktorovich TETS, Viktor Veniaminovich TETS, Alexey Vyacheslavovich STEPANOV
  • ARTICLES AND METHODS DIRECTED TO PERSONALIZED THERAPY OF CANCER
    Publication number: 20220018845
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: July 26, 2021
    Publication date: January 20, 2022
    Applicants: HESPERIX SA, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Alexander Gabibovich Gabibov, Richard A. Lerner, Alexey Anatolievich Belogurov, Jia Xie
  • Articles and methods directed to personalized therapy of cancer
    Patent number: 11215618
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: January 4, 2022
    Assignees: HESPERIX SA, The Scripps Research Institute
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
  • ARTICLES AND METHODS DIRECTED TO PERSONALIZED THERAPY OF CANCER
    Publication number: 20210333282
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: August 3, 2020
    Publication date: October 28, 2021
    Applicants: HESPERIX SA, The Scripps Research Institute
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
  • REPROGRAMMING OF POLYMORPHONUCLEAR LEUKOCYTES
    Publication number: 20210069242
    Abstract: The application is directed a method of treating a cancer in subject by administering to the subject a therapeutically effective amount of polymorphonuclear leukocytes genetically modified to express a recombinant chimeric antigen receptor (CAR) or T cell receptor (TCR). Further provided are modified polymorphonuclear leukocytes and related compositions for use in such methods.
    Type: Application
    Filed: April 17, 2020
    Publication date: March 11, 2021
    Inventors: Dmitry Dmitrievich GENKIN, Alexey Vyacheslavovich Stepanov, Michael Vladimirovich Dubina, Alexey Alexandrovich Bogdanov, Alexander Gabibovich Gabibov
  • ARTICLES AND METHODS DIRECTED TO PERSONALIZED THERAPY OF CANCER
    Publication number: 20200400676
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: August 3, 2020
    Publication date: December 24, 2020
    Applicants: OPKO Pharmaceuticals, LLC, The Scripps Research Institute, Shemyakin-Ovchinnikov institute of Bioorganic Chemistry, Russian Academy of Sciences, PJSC Pharmsynthez
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
  • ARTICLES AND METHODS DIRECTED TO PERSONALIZED THERAPY OF CANCER
    Publication number: 20200363420
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: August 3, 2020
    Publication date: November 19, 2020
    Applicants: OPKO Pharmaceuticals, LLC, The Scripps Research Institute, Shemyakin-Ovchinnikov institute of Bioorganic Chemistry, Russian Academy of Sciences, PJSC Pharmsynthez
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
  • ARTICLES AND METHODS DIRECTED TO PERSONALIZED THERAPY OF CANCER
    Publication number: 20200271657
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: October 4, 2018
    Publication date: August 27, 2020
    Applicants: OPKO Pharmaceuticals, LLC, The Scripps Research Institute, Bioorganic Chemistry, Russian Academy of Sciences, PJSC Pharmsynthez
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie