Patents by Inventor Alexi GORANOV

Alexi GORANOV has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENOMIC ENGINEERING OF BIOSYNTHETIC PATHWAYS LEADING TO INCREASED NADPH
    Publication number: 20240067997
    Abstract: The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an altered GAPDH, expressing a variant glutamate dehydrogenase (gdh), aspartate semialdehyde dehydrogenase (asd), dihydropicolinate reductase (dapB), and meso-diaminopimelate dehydrogenase (ddh), expressing a novel nicotinamide nucleotide transhydrogenase, expressing a novel threonine aldolase, and expressing or modulating the expression of a pyruvate carboxylase in the host cells.
    Type: Application
    Filed: October 7, 2022
    Publication date: February 29, 2024
    Inventors: Shawn MANCHESTER, Benjamin MASON, Alexi GORANOV
  • Genomic engineering of biosynthetic pathways leading to increased NADPH
    Patent number: 11519012
    Abstract: The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an altered GAPDH, expressing a variant glutamate dehydrogenase (gdh), aspartate semialdehyde dehydrogenase (asd), dihydropicolinate reductase (dapB), and meso-diaminopimelate dehydrogenase (ddh), expressing a novel nicotinamide nucleotide transhydrogenase, expressing a novel threonine aldolase, and expressing or modulating the expression of a pyruvate carboxylase in the host cells.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 6, 2022
    Assignee: Zymergen Inc.
    Inventors: Shawn Manchester, Benjamin Mason, Alexi Goranov
  • GENOMIC ENGINEERING OF BIOSYNTHETIC PATHWAYS LEADING TO INCREASED NADPH
    Publication number: 20200263214
    Abstract: The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an altered GAPDH, expressing a variant glutamate dehydrogenase (gdh), aspartate semialdehyde dehydrogenase (asd), dihydropicolinate reductase (dapB), and meso-diaminopimelate dehydrogenase (ddh), expressing a novel nicotinamide nucleotide transhydrogenase, expressing a novel threonine aldolase, and expressing or modulating the expression of a pyruvate carboxylase in the host cells.
    Type: Application
    Filed: May 18, 2018
    Publication date: August 20, 2020
    Inventors: Shawn Manchester, Benjamin Mason, Alexi Goranov
  • A HIGH-THROUGHPUT (HTP) GENOMIC ENGINEERING PLATFORM FOR IMPROVING SACCHAROPOLYSPORA SPINOSA
    Publication number: 20200115705
    Abstract: The present disclosure provides a HTP microbial genomic engineering platform for Saccharopolyspora spp. that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition.
    Type: Application
    Filed: June 6, 2018
    Publication date: April 16, 2020
    Applicant: Zymergen Inc.
    Inventors: Benjamin MASON, Alexi GORANOV, Peter KELLY, Youngnyun KIM, Sheetal MODI, Nihal PASUMARTHI, Benjamin MIJTS, Peter ENYEART