Abstract: Methods for treating seizures in a subject having epilepsy are provided. The method may comprise administering a pharmaceutical composition comprising CBD and THC to the subject. In some embodiments, the ratio of CBD to THC in the pharmaceutical composition is between about 14:1 and about 17:1. Related uses of the pharmaceutical composition to treat seizures in a subject having epilepsy are also provided.

Abstract: The disclosure provides aqueous compositions comprising a rheology modifier comprising a water-swelling polymer and a co-emulsifier that are suitable for preparing cream formulations containing an oil. In one example, the composition comprises PPG-3 benzyl ether ethylhexanoate, glycerin and a rheology modifier comprising sodium polyacrylate, ethylhexyl cocoate, PPG-3 benzyl ether myristate, a co-emulsifier such as polysorbate 20, and an antimicrobial agent. Cream formulations can be prepared by mixing the aqueous composition and an oil without heating and provide desirable characteristics for topical use such as oil capacity and skin feel. The disclosure also provides associated methods as well as uses of the compositions for treating a medical condition.