Patents by Inventor Alexios-Leandros Skaltsounis

Alexios-Leandros Skaltsounis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-BROMO-INDIRUBINS
    Publication number: 20220274964
    Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
    Type: Application
    Filed: March 9, 2022
    Publication date: September 1, 2022
    Inventors: Richard JOVE, Sangkil NAM, David HORNE, Jun XIE, Alexios Leandros SKALTSOUNIS, Marina KRITSANIDA, Nicolas GABORIAUD-KOLAR
  • 5-bromo-indirubins
    Patent number: 11306072
    Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: April 19, 2022
    Assignees: City of Hope, National and Kapodistrian University of Athens
    Inventors: Richard Jove, Sangkil Nam, David Horne, Jun Xie, Alexios Leandros Skaltsounis, Marina Kritsanida, Nicolas Gaboriaud-Kolar
  • Thioindirubins
    Patent number: 11213510
    Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using thioindirubin derivatives.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: January 4, 2022
    Assignees: City of Hope, National and Kapodistrian University of Athens
    Inventors: Sangkil Nam, David Horne, Ravi Salgia, Alexios Leandros Skaltsounis, Nicolas Gaboriaud-Kolar, Panagiotis Gerolymatos, Nikolaos Lougiakis
  • Pyridopyrazine compounds and uses thereof
    Patent number: 11117894
    Abstract: Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: September 14, 2021
    Assignees: City of Hope, National and Kapodistrian University of Athens
    Inventors: Sangkil Nam, David Horne, Ravi Salgia, Alexios-Leandros Skaltsounis, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos
  • PYRIDOPYRAZINE COMPOUNDS AND USES THEREOF
    Publication number: 20210139476
    Abstract: Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.
    Type: Application
    Filed: June 21, 2018
    Publication date: May 13, 2021
    Inventors: Sangkil Nam, David Horne, Ravi Salgia, Alexios-Leandros Skaltsounis, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos
  • THIOINDIRUBINS
    Publication number: 20200345693
    Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using thioindirubin derivatives.
    Type: Application
    Filed: August 30, 2018
    Publication date: November 5, 2020
    Inventors: Sangkil Nam, David Horne, Ravi Salgia, Alexios Leandros Skaltsounis, Nicolas Gaboriaud-Kolar, Panagiotis Gerolymatos, Nikolaos Lougiakis
  • 5-BROMO-INDIRUBINS
    Publication number: 20200283421
    Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
    Type: Application
    Filed: February 13, 2020
    Publication date: September 10, 2020
    Inventors: Richard Jove, Sangkil Nam, David Horne, Jun Xie, Alexios Leandros Skaltsounis, Marina Kritsanida, Nicolas Gaboriaud-Kolar
  • 5-BROMO-INDIRUBINS
    Publication number: 20180170915
    Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 21, 2018
    Inventors: Richard Jove, Sangkil Nam, David Horne, Jun Xie, Alexios Leandros Skaltsounis, Marina Kritsanida, Nicolas Gaboriaud-Kolar
  • Indirubin derivatives and uses thereof in treating chronic myelogenous leukemia
    Patent number: 9512076
    Abstract: Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). One aspect of the invention relates to a method of treating CML using at least one indirubin derivative compound or a pharmaceutical composition thereof. Indirubin derivatives (IRDs) potently inhibited Signal Transducer and Activator of Transcription 5 (Stat5) protein in CML cells. Compound IRD 810 inhibits Bcr-Abl/Stat5 or Src/Stat5 signaling in human KCL-22 CML and imatinib-resistant human KCL-22 CML cells expressing the T315I mutant Bcr-Abl. Previous studies indicate that SFKs cooperate with Bcr-Abl to activate downstream Stat5 signaling. Activation of Stat5 was strongly blocked by IRD 810 in CML cells. IRDs disclosed herein have been identified as potent inhibitors of Bcr-Abl/Stat5 or SFK/Stat5 signaling pathway.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: December 6, 2016
    Assignee: CITY OF HOPE
    Inventors: Richard Jove, Sangkil Nam, Alexios-Leandros Skaltsounis
  • 5-BROMO-INDIRUBINS
    Publication number: 20160068517
    Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 10, 2016
    Inventors: Richard Jove, Sangkil Nam, David Horne, Jun Xie, Alexios Leandros Skaltsounis, Marina Kritsanida, Nicolas Gaboriaud-Kolar
  • Compounds and compositions derived from olives and methods of the use thereof
    Patent number: 6906100
    Abstract: The preparation of extracts from olive fruits, olive tree leaves, olive oil as well as olive-press waste. The isolation of natural products from these extracts and the evaluation of the DNA protective antioxidant activity of the extracts and the purified compounds on intact cells.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: June 14, 2005
    Assignee: Lavipharm S.A.
    Inventors: Spiros Fotinos, Ligia Panaitescu, Alexios-Leandros Skaltsounis, Sofia Mitakou, Prokopios Magiatis, Nektarios Aligiannis, Dimitrios Galaris
  • COMPOUNDS AND COMPOSITIONS DERIVED FROM OLIVES AND METHODS OF USE THEREOF
    Publication number: 20030185921
    Abstract: The preparation of extracts from olive fruits, olive tree leaves, olive oil as well as olive-press waste. The isolation of natural products from these extracts and the evaluation of the DNA protective antioxidant activity of the extracts and the purified compounds on intact cells.
    Type: Application
    Filed: February 10, 2003
    Publication date: October 2, 2003
    Inventors: Spiros Fotinos, Ligia Panaitescu, Alexios-Leandros Skaltsounis, Sofia Mitakou, Prokopios Magiatis, Nektarios Aligiannis, Dimitrios Galaris
  • Acronycine analogues
    Patent number: 5567707
    Abstract: Compounds of formula (I): ##STR1## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Y are defined in the description.Those compounds are used therapeutically in the treatment of cancerous tumours.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: October 22, 1996
    Assignee: Adir et Compagnie
    Inventors: Michel Koch, Fran.cedilla.ois Tillequin, Alexios-Leandros Skaltsounis, Yves Rolland, Alain Pierre, Ghanem Atassi