Patents by Inventor ALEXIS BEMELMANS

ALEXIS BEMELMANS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Promoters and uses thereof
    Patent number: 11390866
    Abstract: The present invention relates to a nucleic acid sequence derived from the regulatory region of the human gamma-synuclein gene and having a promoter activity in retinal ganglion cells. The present invention also relates to expression cassettes or vectors comprising said promoter operably linked to a nucleic acid sequence encoding a polypeptide of interest as well as viral particles or host cells comprising said expression cassette or vector. The present invention also relates to the use of said expression cassettes, vectors, viral particles or cells in the treatment of ocular disease, in particular ocular disease associated with retinal ganglion cell or photoreceptor cell degeneration.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: July 19, 2022
    Assignees: SORBONNE UNIVERSITÉ, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Deniz Dalkara, Serge Picaud, Melissa Desrosiers, Jose-Alain Sahel, Jens Duebel, Alexis Bemelmans, Botond Roska
  • PROMOTERS AND USES THEREOF
    Publication number: 20180355354
    Abstract: The present invention relates to a nucleic acid sequence derived from the regulatory region of the human gamma-synuclein gene and having a promoter activity in retinal ganglion cells. The present invention also relates to expression cassettes or vectors comprising said promoter operably linked to a nucleic acid sequence encoding a polypeptide of interest as well as viral particles or host cells comprising said expression cassette or vector. The present invention also relates to the use of said expression cassettes, vectors, viral particles or cells in the treatment of ocular disease, in particular ocular disease associated with retinal ganglion cell or photoreceptor cell degeneration.
    Type: Application
    Filed: December 5, 2016
    Publication date: December 13, 2018
    Inventors: DENIZ DALKARA, SERGE PICAUD, MELISSA DESROSIERS, JOSE-ALAIN SAHEL, JENS DUEBEL, ALEXIS BEMELMANS, BOTOND ROSKA
  • RECOMBINANT VIRUSES CODING FOR A GLUTAMATE DECARBOXYLASE (GAD) ACTIVITY
    Publication number: 20020028212
    Abstract: Recombinant viruses comprising a heterologous DNA sequence coding for a protein having glutamate decarboxylase (GAD) activity, preparation thereof, and therapeutic use thereof, in particular for treating and/or preventing degenerative neurological diseases.
    Type: Application
    Filed: November 5, 1996
    Publication date: March 7, 2002
    Inventors: MARIE-CLAUDE GEOFFROY, PHILIPPE HORELLOU, JEAN-FRANCOIS JULIEN, JACQUES MALLET, MICHEL PERRICAUDET, JEAN-JACQUES ROBERT, EMMANUELLE VIGNE, ALEXIS BEMELMANS