Patents by Inventor Alexis Broisat

Alexis Broisat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-MESOTHELIN RADIOLABELLED SINGLE DOMAIN ANTIBODIES SUITABLE FOR THE IMAGING AND TREATMENT OF CANCERS
    Publication number: 20200197547
    Abstract: Mesothelin (MSLN) has been found to be overexpressed in several human malignancies: 100% of epithelial mesotheliomas, the majority of pancreatic and ovarian adenocarcinomas, more than 50% of lung adenocarcinomas and 34 to 67% of triple negative breast cancer (TNBC). The limited expression of mesothelin in normal human tissues and its overexpression in several aggressive human cancers make MSLN an attractive candidate for therapy. The objective of the inventors was to perform the nuclear imaging of TNBC xenografts with anti-MSLN single domain antibodies radiolabeled with 99mTc (99mTc-A1 and 99mTc-C6). They showed that 99mTc-A1 represent a good candidate for targeting mesothelin positive tumors. Accordingly, the present invention to an anti-mesothelin single domain antibody which is labelled with a radionuclide and its uses for imaging and/or treating cancer.
    Type: Application
    Filed: August 29, 2018
    Publication date: June 25, 2020
    Inventors: Alexis BROISAT, Catherine GHEZZI, Christopher MONTEMAGNO, Daniel FAGRET
  • Anti-VCAM-1 nanobodies
    Patent number: 9771423
    Abstract: The present invention relates to nanobodies specifically directed against VCAM-1 and to their use in medical imaging and in diagnostic, prognostic and treatment methods.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: September 26, 2017
    Assignees: VIRJE UNIVERSITEIT BRUSSEL, CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, UNIVERSITE GRENOBLE ALPES
    Inventors: Catherine Ghezzi, Daniel Fagret, Alexis Broisat, Nick Devoogdt, Tony Lahoutte, Serge Muydermans
  • ANTI-VCAM-1 NANOBODIES
    Publication number: 20140255303
    Abstract: The present invention relates to nanobodies specifically directed against VCAM-1 and to their use in medical imaging and in diagnostic, prognostic and treatment methods.
    Type: Application
    Filed: August 22, 2012
    Publication date: September 11, 2014
    Applicant: UNIVERSITE JOSEPH FOURIER- GRENOBLE 1
    Inventors: Catherine Ghezzi, Daniel Fagret, Alexis Broisat, Nick Devoogdt, Tony Lahoutte, Serge Muydermans