Patents by Inventor Alexis Denis
Alexis Denis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6440941Abstract: A subject of the invention is the compounds of formula (I) in which Y represents a hydrogen atom or a fluorine atom, n represents an integer comprised between 1 and 8, Z represents a hydrogen atom or the remainder of a carboxylic acid, optionally substituted on the heterocycle by one or more alkyl, alkenyl, alkynyl, O-alkyl, O-alkenyl, O-alkynyl, S-alkyl, S-alkenyl, S-alkynyl radicals containing up to 8 carbon atoms, one or more OH, NH2, C═N, NO2, CF3 radicals or one or more aryl radicals containing up to 14 carbon atoms or heteroaryl radicals containing one or more nitrogen oxygen or sulphur atoms, the aryl or heteroaryl radicals themselves being able to be substituted as well as their addition salts with acids, The products of formula (I) have antibiotic properties.Type: GrantFiled: November 18, 1999Date of Patent: August 27, 2002Assignee: Aventis Pharma S.A.Inventor: Alexis Denis
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Publication number: 20020111319Abstract: Novel compounds of the formula 1Type: ApplicationFiled: February 13, 2002Publication date: August 15, 2002Inventors: Constantin Agouridas, Francois Bretin, Alexis Denis, Claude Fromentin
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Patent number: 6433151Abstract: The invention relates to compounds of the formula (I) in which R represents a radical (CH2)mOn(X)YAr in which m represents the number 0 or 1, n represents the number 0 or 1, X represents a radical (NH)a, CH2 or SO2, where a represents the number 0 or 1, Y represents a radical (CH2)b—(CH═CH)c—(CH2)d, where c=0 or 1 and b+c+d ≦8, Z represents a hydrogen or halogen atom, Ar represents an optionally substituted aryl or heteroaryl radical and W represents a hydrogen atom or an acyl radical, and their acid addition salts. The compounds of the formula (1) have antibiotic properties.Type: GrantFiled: July 8, 1999Date of Patent: August 13, 2002Assignee: Aventis Pharma S.A.Inventors: Alexis Denis, Giuseppe Gigliotti
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Patent number: 6407257Abstract: A subject of the invention is, as new chemical products, the compounds of formula (I) in which X represents a hydrogen atom or a halogen atom and Z represents a hydrogen atom or the remainder of an acid as well as their addition salts with acids. The compounds of formula (I) have antibiotic properties.Type: GrantFiled: December 11, 2000Date of Patent: June 18, 2002Assignee: Aventis Pharma S.A.Inventors: Constantin Agouridas, Alexis Denis, Claude Fromentin
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Publication number: 20020028781Abstract: A subject of the invention is, as new chemical products, the compounds of formula (I) 1Type: ApplicationFiled: December 11, 2000Publication date: March 7, 2002Applicant: Hoechst Marion RousselInventors: Constantin Agouridas, Alexis Denis, Claude Fromentin
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Patent number: 6352983Abstract: Novel compounds of the formula wherein the substituents are defined as in the application having antibiotic properties.Type: GrantFiled: October 8, 1999Date of Patent: March 5, 2002Assignee: Aventis Pharma S.A.Inventors: Constantin Agouridas, Francois Bretin, Alexis Denis, Claude Fromentin
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Publication number: 20020013281Abstract: A subject of the invention is, as new chemical products, the compounds of formula (I) 1Type: ApplicationFiled: November 3, 1999Publication date: January 31, 2002Inventors: CONSTANTIN AGOURIDAS, ALEXIS DENIS, CLAUDE FROMENTIN
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Patent number: 6313101Abstract: A compound of the formula wherein X=CH2 or NH, Y=H or Hal, Z=H or acyl of an organic carboxylic acid of 1 to 6 carbon atoms, R is W and W′ are individually H, Hal and alkyl of 1 to 8 carbon atoms optionally substituted by at least one halogen having antibiotic properties.Type: GrantFiled: February 3, 2000Date of Patent: November 6, 2001Assignee: Aventis Pharma S.A.Inventors: Alexis Denis, Claude Fromentin, Bertrand Heckmann
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Patent number: 6162793Abstract: The compounds of formula (I): ##STR1## in which R is a hydrogen atom, an alkyl, optionally substituted by a halogen atom or a (CH.sub.2).sub.m Ar radical or a ##STR2## in which m represents an integer (1-8), n and p, identical or different, represent an integer (0-6), A and B, identical or different, represent a hydrogen or a halogen or an alkyl and Ar represents an aryl or heteroaryl, and Z represents a hydrogen or the remainder of a carboxylic acid, preparation process and use as medicaments.Type: GrantFiled: February 11, 1999Date of Patent: December 19, 2000Assignee: Hoechst Marion RousselInventors: Constantin Agouridas, Jean-Francois Chantot, Alexis Denis, Jean-Marie Pejac
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Patent number: 6100404Abstract: Intermediates for the preparation of compounds selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## n is an integer from 3 to 5, Ar is an optionally substituted heterocyclic selected from the group consisting ofType: GrantFiled: January 9, 1997Date of Patent: August 8, 2000Assignee: Hoechst Marion RousselInventors: Constantin Agouridas, Jean-Francois Chantot, Alexis Denis, Solange Gouin D'Ambrieres, Odile Le Martret
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Patent number: 5770579Abstract: Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', b is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.Type: GrantFiled: January 25, 1995Date of Patent: June 23, 1998Assignee: Roussel UclafInventors: Constantin Agouridas, Yannick Benedetti, Jean-Fran.cedilla.ois Chantot, Alexis Denis, Claude Fromentin, Odile Le Martret
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Patent number: 5760233Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.Type: GrantFiled: February 25, 1997Date of Patent: June 2, 1998Assignee: Roussel UclafInventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
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Patent number: 5656607Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.Type: GrantFiled: March 31, 1995Date of Patent: August 12, 1997Assignee: Roussel UclafInventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
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Patent number: 5635485Abstract: An erythromycin compound of Formula I or its non-toxic acid addition salt having antibiotic activity.Type: GrantFiled: April 21, 1995Date of Patent: June 3, 1997Assignee: Roussel UclafInventors: Constantin Agouridas, Jean-Francois Chantot, Alexis Denis, Solange G. D'Ambrieres, Odile L. Martret
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Patent number: 5614614Abstract: Novel intermediates for the preparation of the compounds of Formula I wherein the substituents are as defined in the specification.Type: GrantFiled: February 21, 1995Date of Patent: March 25, 1997Assignee: Roussel UclafInventors: Constantin Agouridas, Alain Bonnefoy, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
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Patent number: 5561118Abstract: Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, or X is ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-0 ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', B is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or A is ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.Type: GrantFiled: March 31, 1994Date of Patent: October 1, 1996Assignee: Roussel UclafInventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Claude Fromentin, Odile Le Martret
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Patent number: 5543400Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## m and n are individually integers from 0 to 6, A and B are individually a member selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, the double bond geometry being E or Z or E+Z or A and B form a third bond between the carbon atoms to which they are attached, Ar is selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms optionally substituted with at least one member of the group consisting of free carboxy, alkoxycarbonyl, carboxy salified with a non-toxic, pharmaceutically acceptable base, amidified carboxy, --OH, halogen, --NO.sub.2, --CN, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio and alkynylthio of up to 12 carbon atoms, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms and cycloalkyl of 3 to 12 carbon atoms, all optionally substituted with at least one halogen and ##STR3## R.sub.1 and R.sub.Type: GrantFiled: November 1, 1993Date of Patent: August 6, 1996Assignee: Roussel UclafInventors: Constantin Agouridas, Alain Bonnefoy, Jean-Fran.cedilla.ois Chantot, Alexis Denis, Odile Le Martret
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Patent number: 5527780Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is --(CH.sub.2).sub.n --Ar.sub.1 or --XAr.sub.2, n is an integer from 1 to 6, Ar.sub.1 and Ar.sub.2 are individually selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms substituted by at least one member of the group consisting of free carboxy, alkoxy carbonyl and carboxyl salified with a pharmaceutically acceptable base, --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms optionally substituted with at least one halogen, R.sub.1 and R.sub.2 are individually hydrogen or alkyl of 1 to 12 carbon atoms, b) ##STR3## wherein R.sub.Type: GrantFiled: November 1, 1993Date of Patent: June 18, 1996Assignee: Roussel UclafInventors: Constantin Agouridas, Alain Bonnefoy, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
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Patent number: 5444051Abstract: Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted,or X is ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', B is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.Type: GrantFiled: June 28, 1993Date of Patent: August 22, 1995Assignee: Roussel UCLAFInventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Claude Fromentin, Odile Le Martret
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Patent number: 5439889Abstract: All possible stereoisomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein the substituents are as defined in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.Type: GrantFiled: March 7, 1994Date of Patent: August 8, 1995Assignee: Roussel UclafInventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis