Patents by Inventor Alexis ROVNER

Alexis ROVNER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAMMALIAN CELLS AND METHODS FOR ENGINEERING THE SAME
    Publication number: 20240076655
    Abstract: The present disclosure provides mammalian cell lines for expression of viral vectors, and methods of making and using the same. Provided methods employ use of identifiers that are capable of being packaged into a viral vector to select and/or identify mammalian cell lines with engineered sequences associated with beneficial characteristics for viral vectors production. Exemplary viral vectors include AAV vectors.
    Type: Application
    Filed: October 23, 2023
    Publication date: March 7, 2024
    Inventors: Alexis Rovner, Gaurab Chakrabarti, David Thompson, Gregory Sieczkiewicz, McKenna Hicks, Joseph Bellucci
  • MAMMALIAN CELLS AND METHODS FOR ENGINEERING THE SAME
    Publication number: 20240052341
    Abstract: The present disclosure provides mammalian cell lines for expression of viral vectors, and methods of making and using the same. Provided methods employ use of identifiers that are capable of being packaged into a viral vector to select and/or identify mammalian cell lines with engineered sequences associated with beneficial characteristics for viral vectors production. Exemplary viral vectors include AAV vectors.
    Type: Application
    Filed: September 1, 2021
    Publication date: February 15, 2024
    Inventors: Alexis Rovner, Gaurab Chakrabarti, David Thompson, Gregory Sieczkiewicz, McKenna Hicks, Joseph Bellucci
  • ENGINEERED ORGANISMS AND USES THEREOF IN THE PRODUCTION OF BIOLOGICS, REAGENTS, DIAGNOSTICS AND RESEARCH TOOLS
    Publication number: 20220282263
    Abstract: Provided herein are methods of generating engineered organisms with targeted genome designs, such as recoding designs, and targeted functional properties. Also provided are methods of generating biomanufacturing engineered organisms and uses thereof for production of biomanufactured products.
    Type: Application
    Filed: May 14, 2020
    Publication date: September 8, 2022
    Inventors: Ryan Gallagher, Alexis Rovner, George Church, Jeffrey Way, Pamela Silver
  • Compositions and methods for biocontainment of microorganisms
    Patent number: 11408007
    Abstract: Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (GMO) including the safeguards, and methods of use thereof are provided. The genetic safeguards generally impart a low escape frequency, are robust, and are modular. Safeguards with low escape frequency prevent the rise of mutants escaping defined media and limit growth in the wild. Robust safeguards retain wild-type levels of fitness while also maintaining containment in diverse growth conditions.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: August 9, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Farren J. Isaacs, Ryan Gallagher, Jaymin Patel, Alexis Rovner
  • ENGINEERED ORGANISMS AND USES THEREOF AS LIVING MEDICINES, RESEARCH TOOLS, FOOD PRODUCTS, OR ENVIRONMENTAL TOOLS
    Publication number: 20220228104
    Abstract: Provided herein are engineered organism containing a transgene in which expression of the transgene in an open environment is prevented or reduced, for example, by recoding designs. Also provided are methods of producing such engineered organism and use of such engineered organisms as therapeutics or for producing food, food supplement, and animal feed products.
    Type: Application
    Filed: May 14, 2020
    Publication date: July 21, 2022
    Inventors: Ryan Gallagher, Alexis Rovner, George Church, Jeffrey Way, Pamela Silver
  • COMPOSITIONS AND METHODS FOR BIOCONTAINMENT OF MICROORGANISMS
    Publication number: 20170240908
    Abstract: Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (GMO) including the safeguards, and methods of use thereof are provided. The genetic safeguards generally impart a low escape frequency, are robust, and are modular. Safeguards with low escape frequency prevent the rise of mutants escaping defined media and limit growth in the wild. Robust safeguards retain wild-type levels of fitness while also maintaining containment in diverse growth conditions.
    Type: Application
    Filed: September 28, 2015
    Publication date: August 24, 2017
    Inventors: Farren J. ISAACS, Ryan GALLAGHER, Jaymin PATEL, Alexis ROVNER