Patents by Inventor Alexis Sauer-Budge
Alexis Sauer-Budge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11337586Abstract: Disclosed herein is an aspiration assembly for attaching to an endoscope. The aspiration assembly comprises an extendable suction tube for aspirating an object (e.g., smoke, blood, blood clot, bone debris, or tissue debris) at or near a surgical site during an endoscopic surgery. The aspiration assembly can further comprise an irrigation tube for directing a fluid to the surgical site for cleaning the endoscope lens. By integrating an extendable suction tube with the endoscope, the technology described herein obviate the need for instrument switching and/or multiple surgeons during the surgery.Type: GrantFiled: April 15, 2016Date of Patent: May 24, 2022Assignees: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION, FRAUNHOFER USA, INC.Inventors: Anand Devaiah, Andre Sharon, Alexis Sauer-Budge, Holger Wirz, Yuzhang Yang, Stephanus Johannes Marcellis Van Der Kemp, Daniel Echeverria
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Patent number: 11331659Abstract: A pipetting device includes a housing, a valve assembly, and an actuator assembly. The housing includes a tip for receiving a capillary tube. The valve assembly includes a shuttle valve having a filling position and a dispensing position and a valve rod. The actuator assembly includes an actuator, a valve trigger, a piston mount, and an indexing mechanism. The actuator extends from the housing and has a push button coupled to a push rod. The valve trigger being configured to engage the valve assembly and includes an aperture configured to receive the piston mount therein. The indexing mechanism is configured to index a rotated position of the push button to a predefined volume of dispensed fluid.Type: GrantFiled: February 14, 2018Date of Patent: May 17, 2022Assignees: FRAUNHOFER USA, INC., CHILDREN'S MEDICAL CENTER CORPORATION, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.Inventors: Alexis Sauer-Budge, Holger Wirz, Samuel J. Brookfield, Nira Pollock, Ronald Janzen
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Publication number: 20200230592Abstract: A pipetting device includes a housing, a valve assembly, and an actuator assembly. The housing includes a tip for receiving a capillary tube. The valve assembly includes a shuttle valve having a filling position and a dispensing position and a valve rod. The actuator assembly includes an actuator, a valve trigger, a piston mount, and an indexing mechanism. The actuator extends from the housing and has a push button coupled to a push rod. The valve trigger being configured to engage the valve assembly and includes an aperture configured to receive the piston mount therein. The indexing mechanism is configured to index a rotated position of the push button to a predefined volume of dispensed fluid.Type: ApplicationFiled: February 14, 2018Publication date: July 23, 2020Applicants: FRAUNHOFER USA, INC., THE CHILDREN'S MEDICAL CENTER CORPORATION, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.Inventors: Alexis Sauer-Budge, Holger Wirz, Samuel J. Brookfield, Nira Pollock, Ronald Janzen
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Publication number: 20180110404Abstract: Disclosed herein is an aspiration assembly for attaching to an endoscope. The aspiration assembly comprises an extendable suction tube for aspirating an object (e.g., smoke, blood, blood clot, bone debris, or tissue debris) at or near a surgical site during an endoscopic surgery. The aspiration assembly can further comprise an irrigation tube for directing a fluid to the surgical site for cleaning the endoscope lens. By integrating an extendable suction tube with the endoscope, the technology described herein obviate the need for instrument switching and/or multiple surgeons during the surgery.Type: ApplicationFiled: April 15, 2016Publication date: April 26, 2018Applicants: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION, FRAUNHOFER USA, INC.Inventors: Anand DEVAIAH, Andre SHARON, Alexis SAUER-BUDGE, Holger WIRZ, Yuzhang YANG, Stephanus Johannes Marcellis VAN DER KEMP, Daniel ECHEVERRIA
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Publication number: 20160136658Abstract: The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is achieved by sequential centrifugation steps. In particular, one aspect of the invention relates to a separation/concentration device which comprises at least a first chamber and a second chamber connected by a first valve, whereby operation of the first valve controls the material transfer from the first chamber to the second chamber. In some embodiments, valve operation can be manually, semi-manually or automatically. Other aspects of the invention relate to single- or multi-chambered separation/concentrator devices, and methods and systems for use. Other aspects of the invention relate to devices for operation of the valves, e.g., semi-manual actuation devices, and automatic inertial activation devices and mechanical actuation devices present in purpose-built centrifuges.Type: ApplicationFiled: October 20, 2015Publication date: May 19, 2016Inventors: Andre SHARON, Alexis SAUER-BUDGE, Aaron SIZE, Holger WIRZ
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Publication number: 20160089217Abstract: A dental implant includes an upper connector portion and lower implantation portion, the connector portion receiving a dental crown or similar prosthesis, the implantation portion having rectangular cross section and linear vertical profile with machine taper. An outer surface of the implantation portion provides frictional fit with a correspondingly shaped surrounding bone surface. A bone removal tool includes a hand-held actuator generating high-frequency, small-amplitude vibration, and an attached metal tool tip having elongated head portion and curved neck portion. The head portion has rectangular cross section and linear taper, and an outer surface of the head portion has a saw-toothed grinding pattern for removing bone. The neck portion is dimensioned and configured to establish mechanical resonance of the tool tip including axial reciprocating action of the head portion in response to the actuator vibration.Type: ApplicationFiled: December 4, 2015Publication date: March 31, 2016Inventors: Robert Gyurko, Serge Dibart, Andre Sharon, Alexis Sauer-Budge, Holger Wirz
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Publication number: 20160000413Abstract: Devices for performing fine-needle aspiration of tissue and methods of using the same are disclosed. The device includes a syringe including a fiber optic probe, a plunger, and a needle and a holder including a coupling mechanism, a first actuator, and a second actuator. The fiber optic probe is configured to move within a lumen of the needle and is guided into the needle by a fiber optic channel. The plunger is configured to create a vacuum in the needle.Type: ApplicationFiled: January 30, 2014Publication date: January 7, 2016Inventors: John C. BRIGGS, Andre SHARON, Alexis SAUER-BUDGE, David CHARGIN, Irving BIGIO, Jennifer ROSEN, Ousama A'AMAR, Aaron SIZE, Stephanie LEE
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Patent number: 9199250Abstract: The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is achieved by sequential centrifugation steps. In particular, one aspect of the invention relates to a separation/concentration device which comprises at least a first chamber (101) and a second chamber (103) connected by a first valve (111), whereby operation of the first valve controls the material transfer from the first chamber to the second chamber. In some embodiments, valve operation can be manually, semi-manually or automatically. Other aspects of the invention relate to single- or multi-chambered separation/concentrator devices, and methods and systems for use. Other aspects of the invention relate to devices for operation of the valves, e.g., semi-manual actuation devices, and automatic inertial activation devices and mechanical actuation devices present in purpose-built centrifuges.Type: GrantFiled: April 30, 2010Date of Patent: December 1, 2015Assignees: Trustees of Boston University, Fraunhofer USA, Inc.Inventors: Andre Sharon, Alexis Sauer-Budge, Aaron Size, Holger Wirz
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Patent number: 9046483Abstract: The invention relates to a method for characterizing a target polynucleic acid by providing a surface containing a channel of a dimension sufficient to allow sequential monomer-by-monomer passage of a single-stranded polynucleic acid, but not of a double-stranded polynucleic acid; providing a source of hybridized target polynucleic acid at the surface; inducing passage of the target polynucleic acid through the channel, whereby the target polynucleic acid undergoes base pair separation (melts) prior to its passage; and making one or more measurements over time as the target polynucleic acid moves relative to the channel yielding data suitable to determine a monomer-dependent characteristic of the target polynucleic acid.Type: GrantFiled: August 8, 2013Date of Patent: June 2, 2015Assignee: President and Fellows of Harvard CollegeInventors: Timothy J. Denison, Alexis Sauer-Budge, Jene A. Golovchenko, Amit Meller, Eric Brandin, Daniel Branton
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Patent number: 8986528Abstract: The invention relates to a method for characterizing a target polynucleic acid by providing a surface containing a channel of a dimension sufficient to allow sequential monomer-by-monomer passage of a single-stranded polynucleic acid, but not of a double-stranded polynucleic acid; providing a source of hybridized target polynucleic acid at the surface; inducing passage of the target polynucleic acid through the channel, whereby the target polynucleic acid undergoes base pair separation (melts) prior to its passage; and making one or more measurements over time as the target polynucleic acid moves relative to the channel yielding data suitable to determine a monomer-dependent characteristic of the target polynucleic acid.Type: GrantFiled: March 28, 2013Date of Patent: March 24, 2015Assignee: President and Fellows of Harvard CollegeInventors: Timothy J. Denison, Alexis Sauer-Budge, Jene A. Golovchenko, Amit Meller, Eric Brandin, Daniel Branton
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Publication number: 20140273046Abstract: Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate antibiotics. In another embodiment, the methods and devices described herein are used to determine susceptibility of bacteria to an antibiotic. The methods also provide a method for determining an appropriate antibiotic to treat an individual having a bacterial infection.Type: ApplicationFiled: May 29, 2014Publication date: September 18, 2014Applicants: Trustees of Boston University, Fraunhofer USA, INC.Inventors: Alexis Sauer-Budge, Andre Sharon, Maxim Kalashnikov, Holger Wirz
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Patent number: 8785148Abstract: Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate antibiotics. In another embodiment, the methods and devices described herein are used to determine susceptibility of bacteria to an antibiotic. The methods also provide a method for determining an appropriate antibiotic to treat an individual having a bacterial infection.Type: GrantFiled: October 28, 2011Date of Patent: July 22, 2014Assignees: Fraunhofer, USA, Inc., Trustees of Boston UniversityInventors: Alexis Sauer-Budge, Andre Sharon, Maxim Kalashnikov, Holger Wirz
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Publication number: 20130313112Abstract: The invention relates to a method for characterizing a target polynucleic acid by providing a surface containing a channel of a dimension sufficient to allow sequential monomer-by-monomer passage of a single-stranded polynucleic acid, but not of a double-stranded polynucleic acid; providing a source of hybridized target polynucleic acid at the surface; inducing passage of the target polynucleic acid through the channel, whereby the target polynucleic acid undergoes base pair separation (melts) prior to its passage; and making one or more measurements over time as the target polynucleic acid moves relative to the channel yielding data suitable to determine a monomer-dependent characteristic of the target polynucleic acid.Type: ApplicationFiled: August 8, 2013Publication date: November 28, 2013Applicant: President and Fellows of Harvard CollegeInventors: Timothy J. DENISON, Alexis Sauer-Budge, Jene A. Golovchenko, Amit Meller, Eric Brandin, Daniel Branton
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Publication number: 20130270115Abstract: The invention relates to a method for characterizing a target polynucleic acid by providing a surface containing a channel of a dimension sufficient to allow sequential monomer-by-monomer passage of a single-stranded polynucleic acid, but not of a double-stranded polynucleic acid; providing a source of hybridized target polynucleic acid at the surface; inducing passage of the target polynucleic acid through the channel, whereby the target polynucleic acid undergoes base pair separation (melts) prior to its passage; and making one or more measurements over time as the target polynucleic acid moves relative to the channel yielding data suitable to determine a monomer-dependent characteristic of the target polynucleic acid.Type: ApplicationFiled: March 28, 2013Publication date: October 17, 2013Inventors: Timothy J. DENISON, Alexis Sauer-Budge, Jene A. Golovchenko, Amit Meller, Eric Brandin, Daniel Branton
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Publication number: 20120122831Abstract: Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate antibiotics. In another embodiment, the methods and devices described herein are used to determine susceptibility of bacteria to an antibiotic. The methods also provide a method for determining an appropriate antibiotic to treat an individual having a bacterial infection.Type: ApplicationFiled: October 28, 2011Publication date: May 17, 2012Applicants: FRAUNHOFER USA, INC., TRUSTEES OF BOSTON UNIVERSITYInventors: Alexis Sauer-Budge, Andre Sharon, Maxim Kalashnikov, Holger Wirz
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Publication number: 20120115705Abstract: The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is achieved by sequential centrifugation steps. In particular, one aspect of the invention relates to a separation/concentration device which comprises at least a first chamber (101) and a second chamber (103) connected by a first valve (111), whereby operation of the first valve controls the material transfer from the first chamber to the second chamber. In some embodiments, valve operation can be manually, semi-manually or automatically. Other aspects of the invention relate to single- or multi-chambered separation/concentrator devices, and methods and systems for use. Other aspects of the invention relate to devices for operation of the valves, e.g., semi-manual actuation devices, and automatic inertial activation devices and mechanical actuation devices present in purpose-built centrifuges.Type: ApplicationFiled: April 30, 2010Publication date: May 10, 2012Applicants: Fraunhofer USA, Inc., Trustees of Boston UniversityInventors: Andre Sharon, Alexis Sauer-Budge, Aaron Size, Holger Wirz
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Publication number: 20120077260Abstract: The present invention relates generally to the control of fluid flow rate and direction on a microfluidic device. In particular, the present invention provides an integrated valveless microfluidic device, where directional fluid control is controlled using off-chip remote valve switching and fluid flow rate changes are controlled using on-chip flow-rate changing fluid reservoirs. The present invention provides methods and systems for directional fluid control and control of fluid flow rate in an integrated microfluidic device which enables processes with different flow rates to be performed on one device without the need of on-chip valves.Type: ApplicationFiled: March 30, 2010Publication date: March 29, 2012Applicants: Fraunhofer USA, Inc., Trustees of Boston UniversityInventors: Andre Sharon, David A. Chargin, Paul Mirsky, Alexis Sauer-Budge
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Publication number: 20110313145Abstract: Disclosed herein are methods for purification of RNA from a sample. The RNA can be total RNA or mRNA. The method involves preparing the sample in a solution of lysis buffer and depositing into a first end of a lysis straw such that the sample solution flows through the matrix of the lysis straw and is eluted from the opposite end of the lysis straw, and depositing the eluted material into a first end of a solid phase extraction (SPE) straw, such that the deposited solution flows through the matrix of the SPE straw towards the opposite end of the SPE straw, and eluting the RNA from the SPE straw by depositing a solution of elution buffer, into the first end of the SPE straw, such that the deposited solution flows through the matrix of the SPE straw and is eluted from the opposite end of the SPE straw, wherein purified RNA from the sample is present in the eluate of the SPE straw.Type: ApplicationFiled: June 10, 2011Publication date: December 22, 2011Applicants: FRAUNHOFER USA, INC., TRUSTEES OF BOSTON UNIVERSITYInventors: Andre Sharon, Anirban Chatterjee, Paul Mirsky, Alexis Sauer-Budge
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Publication number: 20070117214Abstract: Methods and apparatuses for performing assays involving binding material elements with a plurality of bonds over a substantial area of a surface of a resonant device establishing a normalized exposure. The methods and apparatuses also involve controlling an external influence applied to the material elements over a first period of time and measuring a signal during a second period of time that is indicative of the change in the amount of material elements bound to the surface relative to the normalized exposure. In some cases, the measured signals are integrated with respect to time to determine the time averaged amount of material elements bound to the surface.Type: ApplicationFiled: May 2, 2006Publication date: May 24, 2007Applicant: BioScale, Inc.Inventors: Brett Masters, Michael Miller, Alexis Sauer-Budge
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Publication number: 20070037142Abstract: Methods for detecting viruses are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the virus, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.Type: ApplicationFiled: May 2, 2006Publication date: February 15, 2007Applicant: BioScale, Inc.Inventors: Alexis Sauer-Budge, Brett Masters, Michael Miller, Mark Lundstrom