Patents by Inventor Alexis Traynor-Kaplan

Alexis Traynor-Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inositol derivatives for increasing chloride secretion and inhibiting inflammation
    Patent number: 7453006
    Abstract: Inositol derivatives, compositions comprising inositol derivatives, and methods for using compositions comprising inositol derivatives as agents for activating the secretion of chloride ions and/or treatment of inflammation are described.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: November 18, 2008
    Assignee: Inologic, Inc.
    Inventors: Alexis Traynor-Kaplan, Carsten Schultz, Tanja Meyerdierks, Mark Moody, Andrew Schnaars, Jane Smith
  • Camphanylidene and phenylalkyl inositol polyphosphate compounds, compositions, and methods of their use
    Publication number: 20070129336
    Abstract: This invention relates to new camphanylidene and phenyl alkyl inositol polyphosphate derivatives that inhibit the absorption of sodium ions in epithelial cells and regulate inducible nitric oxide synthase (iNOS) in macrophages. The invention provides methods for inhibiting sodium ion absorption by epithelial cells and/or regulating inducible nitric oxide synthase (iNOS) in macrophages, by treating epithelial cells or administering to a patient in need of such treatment a therapeutically effective amount of camphanylidene and/or phenyl alkyl inositol polyphosphate compound. Representative camphanylidene and phenyl alkyl inositol polyphosphate compounds include, for example, 1,2-camphanylidene-myo-inositol 3,4,5,6-tetrakisphosphate octalkis (propionoxymethyl) ester (INO-4996), 2,3-camphanylidene-myo-inositol 1,4,5,6-tetrakisphosphate octakis (propionoxymethyl) ester (INO-4984) and 2-O-butyryl-1-O-(3-phenylpropyl)-myo-inositol 3,4,5,6-tetrakisphosphate octakis (propionoxymethyl) ester (INO-4997).
    Type: Application
    Filed: March 25, 2004
    Publication date: June 7, 2007
    Applicant: Inologic, Inc.
    Inventor: Alexis Traynor-Kaplan
  • Method of modulating sodium ion absorption in epithelial cells
    Publication number: 20050020542
    Abstract: The invention provides methods for modulating sodium ion absorption by epithelial cells, by treating epithelial cells or administering to a patient in need of such treatment a therapeutically effective amount of a sodium uptake modulating inositol polyphosphate compound. The sodium uptake modulating inositol polyphosphate compound can be designed to inhibit or enhance sodium uptake. Representative sodium uptake inhibiting inositol polyphosphate compounds include, for example, 1-octyl-2-O-bu-tyryl-inositol 3,4,5,6-tetrakisphosphate propionoxymethyl ester (INO E2).
    Type: Application
    Filed: September 19, 2002
    Publication date: January 27, 2005
    Inventors: Alexis Traynor-Kaplan, Mark Moody
  • Inositol polyphosphate derivatives and methods of using same
    Patent number: 5977078
    Abstract: The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: November 2, 1999
    Assignee: The Regents of the Univesity of California
    Inventors: Alexis Traynor-Kaplan, Carsten Schultz, Stefan Roemer, Christoph Stadler, Marco Rudolf
  • Inositol polyphosphates and methods of using same
    Patent number: 5880099
    Abstract: The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates.
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: March 9, 1999
    Assignee: The Regents of the University of California
    Inventors: Alexis Traynor-Kaplan, Carsten Schultz, Stefan Roemer, Christoph Stadler, Marco Rudolf