Patents by Inventor Alexis Vallée-Bélisle

Alexis Vallée-Bélisle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KINETICALLY PROGRAMMED SYSTEMS AND REACTIONS FOR MOLECULAR DETECTION
    Publication number: 20210310057
    Abstract: The present disclosure concerns detection systems which are kinetically controlled. In the systems of the present disclosure, the systems are kinetically controlled by a first association constant (k1) between the targeting oligonucleotide and the target, a second association constant (k2) between the targeting oligonucleotide and the signaling oligonucleotide and a third association constant (k3) between the signaling oligonucleotide and an anchoring nucleotide. The system is configured such that k1>k2>k3.
    Type: Application
    Filed: May 31, 2019
    Publication date: October 7, 2021
    Inventors: Alexis VALLEE-BELISLE, Guichi ZHU
  • Steric-hindrance hybridization systems, assays and methods associated thereto
    Patent number: 10352928
    Abstract: The present disclosure provides target detection and quantification systems as well as related methods based on the use of steric hindrance (either created by the target itself or a macromolecular entity used to bind to the target) to prevent or limit the hybridizing between an anchoring oligonucleotide (associated to a substrate) and a signaling oligonucleotide or a combination of signaling oligonucleotides (capable of specifically binding the target or the macromolecular entity).
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: July 16, 2019
    Inventors: Alexis Vallée-Bélisle, Sahar Sadat Mahshid
  • STERIC-HINDRANCE HYBRIDIZATION SYSTEMS, ASSAYS AND METHODS ASSOCIATED THERETO
    Publication number: 20170045503
    Abstract: The present disclosure provides target detection and quantification systems as well as related methods based on the use of steric hindrance (either created by the target itself or a macromolecular entity used to bind to the target) to prevent or limit the hybridizing between an anchoring oligonucleotide (associated to a substrate) and a signaling oligonucleotide or a combination of signaling oligonucleotides (capable of specifically binding the target or the macromolecular entity).
    Type: Application
    Filed: April 2, 2015
    Publication date: February 16, 2017
    Inventors: Alexis Vallée-Bélisle, Sahar Sadat Mahshid
  • Nucleotide-Based Probes and Methods for the Detection and Quantification of Macromolecules and Other Analytes
    Publication number: 20130288923
    Abstract: Provided are unimolecular oligonucleotide probes for detecting a target in a sample. The probes use target binding-induced structural changes to detect the presence of the target in the sample. Also provided are methods of using the probes to detect a target in a sample.
    Type: Application
    Filed: November 21, 2011
    Publication date: October 31, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alexis Vallée-Bélisle, Francesco Ricci, Ryan White, Andrew J. Bonham, Kevin W. Plaxco