Abstract: The present invention relates to a method and system for dosing a pharmaceutical product in a packaging machine having at least one volumetric dosing unit with a dosing chamber. The system check-weighs the volumetrically dosed product with appropriate speed and is integrated into a filling or packaging machine. In accordance with the invention, a volume of a first pharmaceutical component is metered and weighed before being introduced into a package. The procedure is repeated with a second pharmaceutical component. The package containing the components is then weighed. Advantageously, accuracy and precision of the amount of the weighed components can be monitored with the present invention to secure the quality of the pharmaceutical product.

Abstract: The present invention relates to a method for dosing a pharmaceutical product in a packaging machine comprising at least one volumetric dosing unit with a dosing chamber. The method comprises metering a volume of a first component, weighing the first component, introducing the first component into a package and metering a volume of a second component, introduce g the second component into the package and weighing of the package into which the components have being introduced. The invention further relates to a system for dosing a pharmaceutical product in a packaging machine comprising at least one volumetric dosing unit with a dosing chamber. The system comprises at least one volumetric dosing unit for metering a volume of the components. Further, means for introducing the said components into a package and means for weighing the components and the package are comprised.

Abstract: A method for the preparation of homogenous microparticles containing metoprolol by a fluidized bed process. The microparticles have a size distribution of less than 250 &mgr;m and contain at least 80% by weight of metoprolol.

Abstract: A novel process for the purification of poloxamers which contain aldehyde impurities, and particularly for the purification of the poloxamers named poloxamer 188 and poloxamer 407, which process includes dissolving the poloxamer(s) in a solvent which solvent may optionally contain an acid or a mixture of acids; if the solvent in which the poloxamer(s) has been dissolved is free from acid, acid is added; whereafter the aldehydes are removed.