Patents by Inventor Alfio Borghese

Alfio Borghese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR THE PREPARATION OF 3,4-SUBSTITUTED-1,2,5-THIADIAZOLES AND INTERMEDIATES THEREOF
    Publication number: 20090156808
    Abstract: The present invention relates to intermediate compounds useful for the preparation of 1,2,5-thiadiazole compounds, including unsymmetrically substituted compounds such as 4-(3-secondary amino-2-hydroxy-propoxy)-1,2,5-thiadiazole compounds and azacyclic or azabicyclic 1,2,5-thiadiazole compounds and to processes for making the same.
    Type: Application
    Filed: December 7, 2005
    Publication date: June 18, 2009
    Inventors: Alfio Borghese, Vincenzo Mancuso, Alain Merschaert
  • Crystalline forms of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone
    Patent number: 7381826
    Abstract: The present invention provides novel crystalline forms of {2-[1-(3,5-bistrifluoromethylbenzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, compositions thereof, intermediates thereof, methods of using the same, processes for making the same, and processes for making intermediates thereof.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: June 3, 2008
    Assignee: Eli Lilly and Company
    Inventors: Alfio Borghese, David Scott Coffey, Pamela Kaye Footman, Steven Wayne Pedersen, Susan Marie Reutzel-Edens, Shella Lenyonga Tameze, Carsten Timpe, Carsten Weber
  • Novel crystalline forms of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1h-[1,2,3] triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone
    Publication number: 20070078166
    Abstract: The present invention provides novel crystalline forms of {2-[1-(3,5-bistrifluoromethylbenzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, compositions thereof, intermediates thereof, methods of using the same, processes for making the same, and processes for making intermediates thereof.
    Type: Application
    Filed: October 12, 2004
    Publication date: April 5, 2007
    Applicant: Eli Lilly and Company Patent Division
    Inventors: Alfio Borghese, David Coffey, Pamela Footman, Steven Pedersen, Susan Reutzel-Edens, Shella Tameze, Carsten Timpe, Carsten Weber
  • Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
    Publication number: 20040249170
    Abstract: This invention provides a process for the synthesis of(S)-3-Methylamino-1-2-thienyl)-1-propanol, a key intermediate in the synthesis of duloxetine.
    Type: Application
    Filed: July 7, 2004
    Publication date: December 9, 2004
    Inventor: Alfio Borghese
  • Method for resolving chiral (2s) and (2r) chromanes
    Publication number: 20040014994
    Abstract: Disclosed are processes for resolving chiral (2S) and (2R) benzopyrans, racemizing benzopyrans, and recycling racemized benzopyrans to increase yield of a desired enantiomer to provide purified or substantially purified bicyclic amino substituted benzopyran derivatives. Such benzopyran derivatives are preferably chromans which can be coupled with benzoyl derivatives via an amide bond to produce potent platelet aggregation inhibitors.
    Type: Application
    Filed: July 17, 2003
    Publication date: January 22, 2004
    Inventors: Luc Antoine, Pascal Bouquel, Alfio Borghese, Hugo Gorissen, Vien V. Khau, Michael Martinelli, Alain Merschaert, Gerd Ruhter, Carine Rypens
  • Methods for producing amino-substituted chromanes
    Publication number: 20040014804
    Abstract: Disclosed are processes for producing benzopyran compounds, reduced 2-(chroman-2-yl) acetic acid compounds and 2-(6-aminochroman-2-yl)acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
    Type: Application
    Filed: July 15, 2003
    Publication date: January 22, 2004
    Inventors: Luc Antoine, Pascal Bouquel, Alfio Borghese, Hugo Gorissen, Michael Martinelli, Alain Merschaert, Gerd Ruhter, Carine Rypens, Robert Scarborough, Theo Schotten, Jean-Pierre Van Hoeck