Patents by Inventor Alfio Fichera

Alfio Fichera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-racemic trifluoroleucine, and methods of making and using
    Patent number: 7371867
    Abstract: One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluoroleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbon-fluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: May 13, 2008
    Assignee: Trustees of Tufts College
    Inventors: Alfio Fichera, Zihni Bilgicer, Krishna Kumar, Xuechao Xing
  • Non-racemic hexafluoreleucine,and methods of making and using it
    Publication number: 20070112200
    Abstract: One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluoroleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbon-fluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
    Type: Application
    Filed: November 6, 2006
    Publication date: May 17, 2007
    Applicant: Trustees of Tufts College
    Inventors: Alfio Fichera, Zihni Bilgicer, Krishna Kumar, Xuechao Xing
  • Non-racemic hexafluoroleucine, and methods of making and using it
    Patent number: 7132559
    Abstract: One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluorleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbonfluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: November 7, 2006
    Assignee: Trustees of Tufts College
    Inventors: Alfio Fichera, Zihni Bilgicer, Krishna Kumar, Xuechao Xing
  • Non-racemic hexafluoreleucine, and methods of making and using it
    Publication number: 20040138493
    Abstract: One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluorleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbonfluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
    Type: Application
    Filed: March 15, 2004
    Publication date: July 15, 2004
    Inventors: Alfio Fichera, Zihni Bilgicer, Krishna Kumar, Xuechao Xing