Patents by Inventor Alfons Grunenberg

Alfons Grunenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-[4-(amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate
    Publication number: 20100173953
    Abstract: The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.
    Type: Application
    Filed: September 29, 2007
    Publication date: July 8, 2010
    Inventors: Alfons Grunenberg, Juergen Stiehl, Katharina Tenbieg, Birgit Keil
  • NOVEL POLYMORPHOUS FORM AND THE AMORPHOUS FORM OF 5-CHLORO-N-({ (5S)-2-OXO-3[4-(3-OXO-4-MORPHOLINYL(-PHENYL]-1,3-OXAZOLIDINE-5-YL}-METHYL)-2-THIOPHENE CARBOXAMIDE
    Publication number: 20100152189
    Abstract: The present invention relates to a novel polymorphic form and the amorphous form of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene-carboxamide, processes for their preparation, medicaments comprising these forms, and their use in the control of diseases.
    Type: Application
    Filed: September 22, 2006
    Publication date: June 17, 2010
    Applicant: BAYER HEALTHCARE AG
    Inventors: Alfons Grunenberg, Jana Lenz, Gerhard Arnold Braun, Birgit Keil, Christian R. Thomas
  • Crystalline modifications of N-?-(2,4,6-triisopropyl-phenylsulfonyl)-3-hydroxyamidino-(L)- phenylalanine 4-ethoxycarbonylpiperazide and/or salts thereof
    Patent number: 7713980
    Abstract: The present invention relates to novel crystalline modifications of N-?-(2,4,6-triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanine 4-ethoxycarbonylpiperazide and/or salts thereof, which can be used as pharmaceutical agents, and to pharmaceutical compositions and pharmaceutical uses comprising these novel crystalline modifications.
    Type: Grant
    Filed: November 24, 2005
    Date of Patent: May 11, 2010
    Assignee: Wilex AG
    Inventors: Alfons Grunenberg, Jana Lenz
  • Polymorph II of 4-[4-(Amino)-3- Fluorophenoxy]-N-Methylpyridine-2-Carboxamide
    Publication number: 20100113533
    Abstract: The present invention relates to the polymorph II of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.
    Type: Application
    Filed: November 3, 2007
    Publication date: May 6, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Juergen Stiehl, Alfons Grunenberg, Katharina Tenbieg, Birgit Keil
  • POLYMORPH III OF 4-[4-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE
    Publication number: 20100063112
    Abstract: The present invention relates to the polymorph III of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.
    Type: Application
    Filed: November 3, 2007
    Publication date: March 11, 2010
    Inventors: Alfons Grunenberg, Juergen Stiehl, Katharina Tenbieg, Birgit Keil
  • Thermodynamically stable form of a tosylate salt
    Publication number: 20090215833
    Abstract: The present invention relates to a novel form, thermodynamically stable at room temperature, of the tosylate salt of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide, to processes for its preparation, to medicaments comprising it and to its use in the control of disorders.
    Type: Application
    Filed: September 20, 2005
    Publication date: August 27, 2009
    Applicant: Bayer HealthCare AG
    Inventors: Alfons Grunenberg, Jana Lenz
  • Novel Crystalline Form Of Cyano-1-Cyclopropyl-7-1S,6S-2,8-Diazabicyclo[4.3.0]Nonan-8-Yl) -6-Fluoro-1,4-Dihydro-4-Oxo-3-Quinoline Carboxylic Acid
    Publication number: 20080125458
    Abstract: The present invention relates to the trihydrate of pradofloxacin, to a process for its preparation and to antibacterial compositions comprising them.
    Type: Application
    Filed: March 19, 2005
    Publication date: May 29, 2008
    Applicant: BAYER HEALTHCARE AG
    Inventors: Hubert Rast, Iris Heep, Alfons Grunenberg, Werner Hallenbach, Jordi Benet-Buchholz
  • Crystalline Modifications of N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-Hydroxyamidino- (L)- Phenylalanine 4-Ethoxycarbonylpiperazide And/Or Salts Thereof
    Publication number: 20080058346
    Abstract: The present invention relates to novel crystalline modifications of N-?-(2,4,6-triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanine 4-ethoxycarbonylpiperazide and/or salts thereof, which can be used as pharmaceutical agents, and to pharmaceutical compositions and pharmaceutical uses comprising these novel crystalline modifications.
    Type: Application
    Filed: November 24, 2005
    Publication date: March 6, 2008
    Applicant: Wilex AG
    Inventors: Alfons Grunenberg, Jana Lenz
  • Medicaments containing vardenafil hydrochloride trihydrate
    Publication number: 20060111354
    Abstract: The invention relates to a method for producing medicaments that contain vardenafil hydrochloride, essentially as trihydrate in solid form, and to medicaments that can be obtained according to this method
    Type: Application
    Filed: July 3, 2003
    Publication date: May 25, 2006
    Inventors: Peter Serno, Alfons Grunenberg, Andreas Ohm, Rainer Bellinghausen, Eimer Vollers, Jan-Olav Henck
  • Thermodynamically stable form of (R)-3-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid (ramatroban)
    Patent number: 6362214
    Abstract: The present invention relates to a thermodynamically stable modification of the active compound ramatroban of formula (I). The thermodynamically stable form is prepared either by melting of the metastable form and subsequent recrystallization or by seeding a solution of the metastable active compound with a seed crystal of the thermodynamically stable form. The thermodynamically stable active compound can be employed as an asthma agent.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: March 26, 2002
    Assignee: Bayer Yakuhin, Ltd.
    Inventors: Alfons Grunenberg, Karl-Heinz Wahl, Klaus-Peter Voges
  • Crystal modification of CDCH a process for its preparation and pharmaceutical formulations comprising this modification
    Patent number: 5849752
    Abstract: The invention relates to the new monohydrate of 1-cyclopropyl-7-(?S,S!-2,8-diazabicyclo-?4.3.0!non-8-yl)6-fluoro-1,4-dihyd ro-8-methoxy-4-oxo-3-quinolinecarboxylic acid hydrochloride (CDCH), a process for its preparation and pharmaceutical formulations which comprise this monohydrate as the active compound.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: December 15, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alfons Grunenberg, Patrick Bosche
  • Crystalline hydrochloride of (R)-(-)-2-(N-?4-(1,1-dioxido-3-oxo-2,3-dihydro-benzisothiazol-2-yl-)-but yl!-aminomethyl)-chroman
    Patent number: 5830908
    Abstract: The invention relates to the crystalline form of the hydrochloride of the compound (R)-(-)-2-{N-?4-(1,1-dioxido-3-oxo-2,3-dihydro-benzisothiazol-2-yl)-butyl! -aminomethyl}-chroman, which is present as a stable form at room temperature. The crystalline modification V of the hydrochloride is suitable in particular for the preparation of solid medicaments, in particular of medicaments for the treatment of neuronal degenerations.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: November 3, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alfons Grunenberg, Oliver Brehm, Michael Conrad, Dietrich Seidel
  • Pharmaceutical preparation containing a specific crystal modification of isopropyl-(2-methoxyethyl) 1,4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
    Patent number: 5599824
    Abstract: The invention relates to pharmaceutical preparations, containing a specific crystal modification (subsequently called "modification II") of isopropyl-(2-methoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (nimodipine) and to a process for its preparation.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: February 4, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alfons Grunenberg, Ahmed Hegasy, Wolfgang M uck, Gerhard Franckowiak, Rango-Rao Kanikanti