Patents by Inventor Alfons Valera Abril

Alfons Valera Abril has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6432676
    Abstract: The chimeric gene is directed by a promoter or fusion of promoters which preferably are regulable and activated by the diabetic process. Preferably, it is obtained by fusion of the human insulin gene to the promoter of PEPCK (P-enolpiruvate carboxiquinasa). Said promoter (fragment −460 bp to +73 bp) is fused to the flank zone 5′ of the human insulin gene (−170 bp to +1). The gene of the human insulin contains two coding exons E1 and E2 and two introns A and B. It also relates to an expression vector which allows the expression of insulin in cells which are different from the &bgr;-cells of the pancreas, and to a transgenic animal which expresses said chimeric gene. It is especially used for the gene therapy of diabetes.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: August 13, 2002
    Assignee: Universitat Autonoma de Barcelona
    Inventors: Fatima Bosch Tubert, Alfons Valera Abril
  • Patent number: 6137029
    Abstract: The chimeric gene is directed by a promoter or fusion of promoters which preferably are regulable and activated by the diabetic process. Preferably, it is obtained by fusion of the human insulin gene to the promoter of PEPCK (P-enolpiruvate carboxiquinasa). Said promoter (fragment -460 bp to +73 bp) is fused to the flank zone 5' of the human insulin gene (-170 bp to +1). The gene of the human insulin contains two coding exons E1 and E2 and two introns A and B. It also relates to an expression vector which allows the expression of insulin in cells which are different from the .beta.-cells of the pancreas, and to a transgenic mouse which expresses said chimeric gene.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: October 24, 2000
    Assignee: Universitat Autonoma De Barcelona
    Inventors: Fatima Bosch Tubert, Alfons Valera Abril