Abstract: Current mobile devices that feature force feedback touchpads include haptic engines that operate in a narrow bandwidth and therefore cannot be used as a dual-purpose center channel for media playback. Further, a separate dedicated loudspeaker for a center channel would add cost and reduce integration space. The presently disclosed dual-use haptic trackpad loudspeaker can enable an enhanced audio experience without the need for an additional dedicated loudspeaker. The dual-use haptic trackpad loudspeaker can be used for haptics feedback as well as provide audio output over the frequency range 400 Hz to 10 kHz. The dual-use haptic trackpad loudspeaker may use a tuned spring-mass actuator and adopt mechanical properties to provide a specific desired mechanical compliance to the dual-use haptic trackpad loudspeaker.

Abstract: The invention relates to nucleic acid products that interfere with or inhibit CNNM4 (Cyclin M4) gene expression. It further relates to therapeutic uses of CNNM4 inhibition for the treatment of diseases, such as liver diseases including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver steatosis, liver fibrosis, liver cirrhosis, liver cancer and other diseases associated with magnesium dysregulation.

Abstract: Particular embodiments provide a system to determine ad segments in a video asset to enable subsequent ad replacement in video programs. The system is included in a multiple service operator (MSO) system that broadcasts video programs via a broadcast schedule. The MSO may not know the location of the ad segments in the video asset. To determine the ad segments, the MSO uses a classifier to classify video program segments and advertisements in the video asset. The classifier may be integrated with an nDVR system. By integrating with the nDVR system, particular embodiments may determine user behavior information, such as trick play commands, from the nDVR system. The classifier may use the user behavior information to detect ad segments in the video asset. In one embodiment, the classifier may fuse outputs from different detectors to detect and validate ad segments in the video program.

Abstract: The present invention relates to technologies or applications for the mitigation or adaptation to climate change, specifically to the generation of energy through renewable energy sources.

Abstract: Mesh materials for the controlled release of antimicrobial and antiviral compounds, with high antiviral activity and efficacy, predominantly against coronavirus, and a method for producing mesh materials with inclusion compounds of bisbiguanide:cyclodextrin, using mesh materials selected from polymers, fibers, nonwoven fabric, fabrics, paper and cellulose, individually or in combination, or a combination of one or more of these mesh materials with adhesives. The mesh materials impregnated, extruded, saturated, coated or laminated with inclusion compounds have been shown to be effective in the deactivation/destruction of viral particles. In fabrics, the inclusion compounds exhibited virucidal activity for all of the viruses in the coronavirus group for contact times of above 2 minutes, with the effect thereof lasting for more than 30 days. The mesh materials for controlled release of antivirals have displayed activity which is up to 1000 times more effective than the use of unencapsulated chlorhexidine.

Abstract: The invention relates to nucleic acid products that interfere with or inhibit CNNM4 (Cyclin M4) gene expression. It further relates to therapeutic uses of CNNM4 inhibition for the treatment of diseases, such as liver diseases including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver steatosis, liver fibrosis, liver cirrhosis, liver cancer and other diseases associated with magnesium dysregulation.

Abstract: Particular embodiments provide a system to determine ad segments in a video asset to enable subsequent ad replacement in video programs. The system is included in a multiple service operator (MSO) system that broadcasts video programs via a broadcast schedule. The MSO may not know the location of the ad segments in the video asset. To determine the ad segments, the MSO uses a classifier to classify video program segments and advertisements in the video asset. The classifier may be integrated with an nDVR system. By integrating with the nDVR system, particular embodiments may determine user behavior information, such as trick play commands, from the nDVR system. The classifier may use the user behavior information to detect ad segments in the video asset. In one embodiment, the classifier may fuse outputs from different detectors to detect and validate ad segments in the video program.

Abstract: Particular embodiments provide a system to determine ad segments in a video asset to enable subsequent ad replacement in video programs. The system is included in a multiple service operator (MSO) system that broadcasts video programs via a broadcast schedule. The MSO may not know the location of the ad segments in the video asset. To determine the ad segments, the MSO uses a classifier to classify video program segments and advertisements in the video asset. The classifier may be integrated with an nDVR system. By integrating with the nDVR system, particular embodiments may determine user behavior information, such as trick play commands, from the nDVR system. The classifier may use the user behavior information to detect ad segments in the video asset. In one embodiment, the classifier may fuse outputs from different detectors to detect and validate ad segments in the video program.

Abstract: The present invention relates to a CNNM4 inhibitor for use in the treatment of an acute or a chronic liver, kidney and/or lung disease in a subject, and to pharmaceutical compositions comprising a therapeutically effective amount of a CNNM4 inhibitor and a pharmaceutically acceptable excipient or carrier. Furthermore, the invention relates to a method for diagnosing a liver disease, a kidney disease or a lung disease in a subject, and to in vitro methods for identifying a compound potentially useful for reducing an induced CNNM4-mediated disease or condition in a cell.

Abstract: Human polarised three-dimensional cellular aggregates generated in vitro from one or more human pluripotent stem cells are provided. Methods for obtaining human polarised three-dimensional cellular aggregates and cells obtained from the human polarised three-dimensional cellular aggregates are also provided.

Abstract: Polarised three-dimensional cellular aggregates (or gastmloids) generated in vitro from one or more pluripotent stem cells are provided. Methods for obtaining polarised three-dimensional cellular aggregates and cells (e.g. progenitor cells and derivatives thereof) obtained from the polarised three-dimensional cellular aggregates are also provided.

Abstract: The present document describes a process for the preparation of an amino acid supplement formulation and a formulation thereof. The process comprises filtering a clarified whey protein solution with a filter having a molecular weight cut off between about 50 and 300 kDa to obtain a protein solution; dehydrating the protein solution to obtain a powder; and mixing the powder with lecithin. The present document also describes a process for the purification of a whey protein isolate, comprising filtering a clarified whey protein solution with a filter having a molecular weight cut off between about 50 and 300 kDa to obtain a protein solution; and filtering the protein solution with a filter having a molecular weight cut off between about 1 and 100 kDa to obtain a protein solution having at least one of active albumin, beta-lactoglobulin, and alpha-lactalbumin proteins.

Abstract: A method for creating derivative advertisements is provided. The method includes identifying a visual element based on an analysis of a primary advertisement asset such that the visual element is representative of a branding message provided within the primary advertisement. The method also includes identifying a call-to-action (CTA) data element based on the analysis and creating a derivative advertisement asset having the visual element and CTA data element. A system and a non-transitory computer-readable storage medium containing software for executing the method are also provided.

Abstract: Particular embodiments provide a system to determine ad segments in a video asset to enable subsequent ad replacement in video programs. The system is included in a multiple service operator (MSO) system that broadcasts video programs via a broadcast schedule. The MSO may not know the location of the ad segments in the video asset. To determine the ad segments, the MSO uses a classifier to classify video program segments and advertisements in the video asset. The classifier may be integrated with an nDVR system. By integrating with the nDVR system, particular embodiments may determine user behavior information, such as trick play commands, from the nDVR system. The classifier may use the user behavior information to detect ad segments in the video asset. In one embodiment, the classifier may fuse outputs from different detectors to detect and validate ad segments in the video program.

Abstract: A protective enclosure for an electronic device includes a top member adapted to be removably coupled to a bottom member to enclose the electronic device. A first back engagement feature is disposed on an inside surface of a perimeter wall portion of the bottom member, and the first back engagement feature is adapted to engage a first front engagement feature disposed on an inner perimeter wall of the top member to removably secure the top member to the bottom member. A second back engagement feature is disposed on an outside surface of the perimeter wall portion of the bottom member, and the second back engagement feature is adapted to engage a second front engagement feature disposed on an outer perimeter wall of the top member to further removably secure the top member to the bottom member.

Abstract: Particular embodiments provide a system to determine ad segments in a video asset to enable subsequent ad replacement in video programs. The system is included in a multiple service operator (MSO) system that broadcasts video programs via a broadcast schedule. The MSO may not know the location of the ad segments in the video asset. To determine the ad segments, the MSO uses a classifier to classify video program segments and advertisements in the video asset. The classifier may be integrated with an nDVR system. By integrating with the nDVR system, particular embodiments may determine user behavior information, such as trick play commands, from the nDVR system. The classifier may use the user behavior information to detect ad segments in the video asset. In one embodiment, the classifier may fuse outputs from different detectors to detect and validate ad segments in the video program.

Abstract: A method of video segment detection within a transport stream of a video asset is provided. Boundaries of candidate video segments of interest (i.e., advertisements, sports highlights, news highlights, content summaries, etc.) within a video asset are detected with a media analysis detector and are separately detected based on statistical models generated from historic transport control event data collected from a population of viewers of the video asset. The above referenced information concerning the candidate video segments of interest is used to identify beginning and end boundaries of selected candidate video segments within the transport stream. A transcoder is provided with parameters corresponding to the selected candidate video segments and performs group of pictures (GOP) and chunk boundary alignment of chunks of the transport stream with the boundaries of the selected candidate video segments. A system and non-transitory computer-readable storage medium are also disclosed.

Abstract: A method and apparatus determine a multimedia representation for a multimedia asset. The method includes receiving a multimedia asset request for a multimedia asset at a multimedia representation broker. The multimedia asset request is received from a specific client device. The multimedia asset request includes client device information about the specific client device. The method determines, at the multimedia representation broker, a multimedia representation for user in providing the multimedia asset to the specific client device based on the client device information and based on media representations appropriate for a client device context of the specific client device. The method outputs multimedia representation information corresponding to the multimedia asset for the specific client device based on the determined multimedia representation.

Abstract: A protective enclosure for an electronic device includes a top member adapted to be removably coupled to a bottom member to enclose the electronic device. A first back engagement feature is disposed on an inside surface of a perimeter wall portion of the bottom member, and the first back engagement feature is adapted to engage a first front engagement feature disposed on an inner perimeter wall of the top member to removably secure the top member to the bottom member. A second back engagement feature is disposed on an outside surface of the perimeter wall portion of the bottom member, and the second back engagement feature is adapted to engage a second front engagement feature disposed on an outer perimeter wall of the top member to further removably secure the top member to the bottom member.

Abstract: A level-‘n’ cache and method are disclosed. The level-‘n’ cache method comprises: in response to a data access request identifying an address of a data block to be accessed, interrogating an address cache of the level-‘n’ cache arranged to store address portions for a sub-set of data blocks stored in a main cache of the level-‘n’ cache to determine whether a cache hit occurs within the address cache for the address. In this way, providing the address cache which is separate from the main cache, with the address cache storing address portions relating to data blocks stored in the main cache, the amount of data required to be stored in the address cache is reduced, and decouples the size of the address cache from that of the main cache which enables the address cache to be sized independent of the size of the data blocks stored in the main cache.