Patents by Inventor Alfonso Melloni

Alfonso Melloni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
    Patent number: 9604915
    Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: March 28, 2017
    Assignee: ZACH SYSTEMS S.P.A.
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • CYCLOPROPANATION OF SUBSTITUTED PHENYLACETONITRILES OR PHENYL ACETATES
    Publication number: 20160102049
    Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.
    Type: Application
    Filed: June 20, 2014
    Publication date: April 14, 2016
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid
    Patent number: 9290428
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: March 22, 2016
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • Process for preparing Bosentan monohydrate and it's intermediates
    Patent number: 8933226
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: January 13, 2015
    Assignee: Zach Systems S.p.A.
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
  • PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20140378696
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group ?wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.
    Type: Application
    Filed: June 23, 2014
    Publication date: December 25, 2014
    Applicant: CHIESI FARMACEUTICI S.p.A
    Inventors: Massimo VERZINI, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATED
    Publication number: 20130253195
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Application
    Filed: September 22, 2011
    Publication date: September 26, 2013
    Applicant: ZACH SYSTEM SPA
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli