Abstract: Provided herein are methods and compositions related to bacteria of genus Burkholderia useful as therapeutic agents.

Abstract: The present application provides immune cells comprising an HPV antigen and an adjuvant, methods of manufacturing such modified immune cells, and methods of using such modified immune cells for treating an HPV-associated disease, preventing an HPV-associated disease and/or for modulating an immune response in an individual with an HPV-associated disease.

Abstract: A new class of 16-ary Amplitude and Phase Shift Keying (APSK) coded modulations, called double-ring APSK modulation, based on an amplitude and phase shift keying constellation in which the locations of the digital signals to be encoded are placed on two concentric rings of equally spaced signal points. The APSK constellation parameters are optimised so as to pre-compensate the impact of non-linearities. The new modulation scheme is suited for being used with different coding schemes. It is shown that, for the same coding scheme, pre-distorted double-ring APSK modulation significantly outperforms classical 16-QAM and 16-PSK over a typical satellite channel, due to its intrinsic robustness against the high power amplifier non-linear characteristics. The proposed coded modulation scheme is shown to provide a considerable performance advantage for future satellite multi-media and broadcasting systems.