Patents by Inventor Alfred A. Avey

Alfred A. Avey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and use of (R),(R)-2,2?-bis-methylnaltrexone
    Patent number: 8916706
    Abstract: This invention relates to synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: December 23, 2014
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Alfred A. Avey, Julio Perez
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8853232
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: October 7, 2014
    Assignees: Wyeth LLC, Progenics Pharmaceuticals., Inc.
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20140142132
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Application
    Filed: September 4, 2013
    Publication date: May 22, 2014
    Applicants: WYETH, LLC, PROGENICS PHARMACEUTICALS, INC.
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • PREPARATION AND USE OF (R),(R)-2,2'-BIS-METHYLNALTREXONE
    Publication number: 20130296570
    Abstract: This invention relates to synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Application
    Filed: June 6, 2013
    Publication date: November 7, 2013
    Inventors: Alfred A. Avey, Julio Perez
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8546418
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: October 1, 2013
    Assignees: Progenics Pharmaceuticals, Inc., Wyeth, LLC
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • Preparation and use of (R),(R)-2,2?-bis-methylnaltrexone
    Patent number: 8471022
    Abstract: This invention relates to the synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: June 25, 2013
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Alfred A. Avey, Julio Perez
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20110190331
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Application
    Filed: March 28, 2008
    Publication date: August 4, 2011
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • PREPARATION AND USE OF (R),(R)-2,2'-BIS-METHYLNALTREXONE
    Publication number: 20110100099
    Abstract: This invention relates to synthesis of (R),(R)-2,2?-bis-MNTX, as shown in Formula (I), and related methods and products.
    Type: Application
    Filed: February 6, 2008
    Publication date: May 5, 2011
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Alfred A. Avey, Julio Perez
  • Synthesis of imidazole 2-thiones thiohydantoins
    Patent number: 7919630
    Abstract: The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: April 5, 2011
    Assignee: Allergan, Inc.
    Inventors: Michael E. Garst, Lloyd J. Dolby, Shervin Esfandiari, Alfred A. Avey, Jr., Vivian Rose MacKenzie, Charles David Muchmore
  • Processes for Synthesizing Quaternary 4,5-Epoxy-Morphinan Analogs and Isolating their N-Stereoisomers
    Publication number: 20080161570
    Abstract: Methods for the synthesis of 4,5-epoxy-morphinaniums using dimethyl formamide and resolution of the diastereomeric products by means of HPLC.
    Type: Application
    Filed: November 19, 2007
    Publication date: July 3, 2008
    Applicant: Progenerics Pharmaceuticals, Inc.
    Inventors: Julio Perez, Amy Qi Han, Alfred A. Avey
  • SYNTHESIS OF IMIDAZOLE 2-THIONES VIA THIOHYDANTOINS
    Publication number: 20070203344
    Abstract: The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione.
    Type: Application
    Filed: August 29, 2006
    Publication date: August 30, 2007
    Inventors: Michael Garst, Lloyd Dolby, Shervin Esfandiari, Alfred Avey, Vivian MacKenzie, Charles Muchmore
  • Method of making imidazole-2-thiones
    Publication number: 20060122400
    Abstract: The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione.
    Type: Application
    Filed: December 7, 2004
    Publication date: June 8, 2006
    Inventors: Michael Garst, Lloyd Dolby, Shervin Esfandiari, Alfred Avey
  • Process for preparing isomerically pure prodrugs of proton pump inhibitors
    Publication number: 20050038076
    Abstract: Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.
    Type: Application
    Filed: July 13, 2004
    Publication date: February 17, 2005
    Inventors: Michael Garst, Lloyd Dolby, Shervin Esfandiari, Vivian MacKenzie, Alfred Avey, David Muchmore, Geoffrey Cooper, Thomas Malone
  • Method for directly depositing metal containing patterned films
    Patent number: 5534312
    Abstract: A photoresist-free method for making patterned films of metal oxides, metals, or other metal containing compounds is described. The method involves applying an amorphous film of a metal complex to a substrate. The film may be conveniently applied by spin coating using standard industry techniques. The metal complex used is photoreactive and undergoes a low temperature chemical reaction in the presence of light of a suitable wavelength. The end product of the reactions depends upon the atmosphere in which the reactions take place. Metal oxide films may be made in air. Patterned films may be made by exposing only selected portions of the film to light. Patterns of two or more materials may be laid down from the same film by exposing different parts of the film to light in different atmospheres. The resulting patterned film is generally planar. Separate planarization steps are not generally required.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: July 9, 1996
    Assignee: Simon Fraser University
    Inventors: Ross H. Hill, Bentley J. Palmer, Alfred A. Avey, Jr., Sharon L. Blair, Chu-Hui W. Chu, Meihua Gao, Wai L. Law