Patents by Inventor Alfred Chung

Alfred Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8813750
    Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: August 26, 2014
    Assignee: Covidien LP
    Inventors: Michael P. O'Neil, Joel C. Colburn, Gary L. Crumback, Charles E. Porges, Alfred Chung, David Hyde
  • Patent number: 8413659
    Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: April 9, 2013
    Assignee: Covidien LP
    Inventors: Gary L. Crumback, Charles E. Porges, Alfred Chung, David Hyde
  • Publication number: 20100313894
    Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.
    Type: Application
    Filed: August 3, 2010
    Publication date: December 16, 2010
    Applicant: Nellcor Puritan Bennett LLC
    Inventors: Gary L. Crumback, Charles E. Porges, Alfred Chung, David Hyde
  • Publication number: 20100313895
    Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.
    Type: Application
    Filed: August 19, 2010
    Publication date: December 16, 2010
    Applicant: Nellcor Puritan Bennett LLC
    Inventors: Michael P. O'Neil, Joel C. Colburn, Gary L. Crumback, Charles E. Porges, Alfred Chung, David Hyde
  • Publication number: 20080078401
    Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.
    Type: Application
    Filed: September 29, 2006
    Publication date: April 3, 2008
    Inventors: Michael P. O'Neil, Joel C. Colburn, Gary L. Crumback, Charles E. Porges, Alfred Chung, David Hyde
  • Publication number: 20080078405
    Abstract: There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.
    Type: Application
    Filed: September 29, 2006
    Publication date: April 3, 2008
    Inventors: Gary L. Crumback, Charles E. Porges, Alfred Chung, David Hyde
  • Publication number: 20080050736
    Abstract: The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by addition of cysteamine as the target-associative moiety to another molecule or entity having a property or properties useful in discriminating or selecting between members of a set, where such properties could include, for example, fluorescence, mass, affinity, reactivity, size, absorbance, magnetism, subatomic spin characteristics, or an ability to associate specifically or preferentially with certain structures. The invention further relates to a method for analyzing, identifying, or purifying phosphorylated proteins or phosphorylated protein fragments using a tag having the properties of both fluorescence and affinity.
    Type: Application
    Filed: November 9, 2005
    Publication date: February 28, 2008
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Stanley Stevens, Alfred Chung
  • Publication number: 20060099604
    Abstract: The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by addition of cysteamine as the target-associative moiety to another molecule or entity having a property or properties useful in discriminating or selecting between members of a set, where such properties could include, for example, fluorescence, mass, affinity, reactivity, size, absorbance, magnetism, subatomic spin characteristics, or an ability to associate specifically or preferentially with certain structures. The invention further relates to a method for analyzing, identifying, or purifying phosphorylated proteins or phosphorylated protein fragments using a tag having the properties of both fluorescence and affinity.
    Type: Application
    Filed: November 9, 2004
    Publication date: May 11, 2006
    Applicant: The University of Florida Research Foundation, Inc.
    Inventors: Stanley Stevens, Alfred Chung
  • Patent number: 4833152
    Abstract: Novel inhibitors of angiotensin coverting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: May 23, 1989
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4801721
    Abstract: Methods for the alkylation of substituted amines with trifluorate esters is disclosed.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: January 31, 1989
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4766110
    Abstract: Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula ##STR1## wherein R.sub.1 and/or R.sub.3 form complex amides and imides thereof, R.sub.4 and R.sub.5 form with --N--C-- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: August 23, 1988
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4745124
    Abstract: Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula,R.sub.1 -A.sub.1 -S-Z,wherein Z denotes -B-A.sub.2, R.sub.1 is H or an acyl group, A.sub.1 is a carboxylic acid containing at least one amino or imino -N-, A.sub.2 is a carboxylic acid containing at least one amino or imino -N- or a lower alkyl ester or amide thereof, B is a 2-4 carbon backbone chain in mercapto linkage to S which includes a carbonyl or sulfonyl group joined in carboxamido or sulfonamido linkage, respectively, to A.sub.2.Preferably A.sub.2 includes a 4-6 membered C-N ring or a 5 membered ring of one N, one S and 3 C atoms.
    Type: Grant
    Filed: July 20, 1983
    Date of Patent: May 17, 1988
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4734420
    Abstract: Novel inhibitors of angiotensin converting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.
    Type: Grant
    Filed: May 2, 1980
    Date of Patent: March 29, 1988
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4707490
    Abstract: ACE inhibitors containing amino acid esters of thiopropanoyl-L-3,4-dehydroproline are disclosed.
    Type: Grant
    Filed: April 10, 1986
    Date of Patent: November 17, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4698356
    Abstract: Novel compounds are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective antihypertensive agents.
    Type: Grant
    Filed: August 14, 1979
    Date of Patent: October 6, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4698355
    Abstract: Novel compounds are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective antihypertensive agents.
    Type: Grant
    Filed: August 14, 1979
    Date of Patent: October 6, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4695577
    Abstract: Novel compounds are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective antihypertensive agents.
    Type: Grant
    Filed: August 14, 1979
    Date of Patent: September 22, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4695582
    Abstract: The compounds, N-[3-(benzoylphenylalanylthio)-2-D-methylpropanoyl]-L-proline (I), N-(2-benzoylphenylalanylthiopropanoyl)-L-proline (II) and N-(3-benzoylphenylalanylthiopropanoyl)-L-proline (III) are disclosed. These compounds are potent inhibitors of serum angiotensin converting enzyme.
    Type: Grant
    Filed: January 30, 1980
    Date of Patent: September 22, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4692459
    Abstract: Inhibitors of angiotensin converting enzyme which have the formula: ##STR1## wherein R is hydrogen, formyl, acetyl propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert-butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L-glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl;A is L-phenylalanyl, D-phenylalanyl, D,L-alanyl, D-alanyl, D,L-tryptophyl, D-tryptophyl, D,L-tyrosyl, D-tyrosyl, D,L-isoleucyl, D-isoleucyl, D,L-leucyl, D-leucyl, D,L-histidyl, D-histidyl, D,L-valyl, or D-valyl, the .alpha.-amino group thereof being in amide linkage with R;R.sub.1 is hydrogen or methyl;R.sub.2 is L-proline, L-3,4-dehydroproline, D,L-3,4-dehydroproline, L-3-hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4-carboxylic acid, or L-5-oxo-proline, the imino group thereof being in imide linkage with the adjacent ##STR2## and, n is 0 or 1, such that when n is 0, R.sub.1 is methyl are disclosed as useful anti-hypertensive agents.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: September 15, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4692458
    Abstract: Novel inhibitors of angiotensin converting enzyme having the general formula R--A--S--Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.
    Type: Grant
    Filed: March 5, 1980
    Date of Patent: September 8, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung