Patents by Inventor Alfred D. Steinberg

Alfred D. Steinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8309527
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: November 13, 2012
    Assignees: University of Iowa Research Foundation, The United States of America, as represented by the Secretary, Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8258106
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: September 4, 2012
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America, as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Joel N. Kline, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8158592
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: April 17, 2012
    Assignees: Coley Pharmaceutical Group, Inc., The United States of America, as represented by the Department of Health and Human Services, University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8148340
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: April 3, 2012
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Iowa Research Foundation, Pfizer Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8129351
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: March 6, 2012
    Assignees: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8114848
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: February 14, 2012
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8058249
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: November 15, 2011
    Assignees: University of Iowa Research Foundation, United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8008266
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: August 30, 2011
    Assignees: University of Iowa Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Alfred D. Steinberg, Dennis Klinman
  • Patent number: 7879810
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: February 1, 2011
    Assignees: University of Iowa Research Foundation, The United States of America, as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 7723022
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 7723500
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 7713529
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: May 11, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 7674777
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: March 9, 2010
    Assignees: University of Iowa Research Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040229835
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: June 24, 2004
    Publication date: November 18, 2004
    Applicants: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040198688
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: April 2, 2004
    Publication date: October 7, 2004
    Applicants: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., U.S.A., as represented by the Secretary, Department of Health & Human Services
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040181045
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: February 26, 2004
    Publication date: September 16, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040171150
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: February 26, 2004
    Publication date: September 2, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040167089
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: January 30, 2004
    Publication date: August 26, 2004
    Applicants: The University of Iowa Research Foundation, Coley Pharmacuetical Group, Inc., The USA as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040162258
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: January 30, 2004
    Publication date: August 19, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmacuetical Group, Inc., The USA as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20040162262
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: February 26, 2004
    Publication date: August 19, 2004
    Applicants: University of Iowa Research Foundation, Coley Pharmacuetical Group, Inc., The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg