Patents by Inventor Alfred Dirk van het Schip

Alfred Dirk van het Schip has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9999695
    Abstract: The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, the use of the microsphere, a method for detecting a tumor, and a therapeutic composition comprising the microsphere, the powder, or the suspension. The invention provides a method for preparing a microsphere that comprises a lanthanide metal phosphate complex, the method comprising: (a) providing an organic lanthanide metal complex microsphere, wherein the lanthanide metal is present in an amount of more than 20 wt.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: June 19, 2018
    Assignee: UMC UTRECHT HOLDINGS B.V.
    Inventors: Wouter Bult, Johannes Franciscus Wilhelmus Nijsen, Alfred Dirk van Het Schip
  • Patent number: 9731037
    Abstract: The invention provides a scanning suspension comprising a particle which is capable of at least in part disturbing a magnetic field, wherein said particle comprises a diameter of at least 1 ?m, and use thereof for obtaining a scanning image. Preferably, said particle comprises holmium and a composition capable of essentially maintaining its structure during irradiation. A particle of the invention is suitable for preparing a kit of parts, comprising a diagnostic and a therapeutic composition which both comprise particles of the invention with essentially the same chemical structure, wherein said therapeutic composition is more radioactive than said diagnostic composition. Said kit of parts is especially suitable for treatment of a tumor. First, the distribution of a particle of the invention within an individual can be determined with a scanning image obtained with said scanning composition.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: August 15, 2017
    Assignees: Universitair Medisch Centrum Utrecht, Universiteit Utrecht Holding B.V.
    Inventors: Johannes Franciscus Wilhelmus Nijsen, Alfred Dirk Van Het Schip, Bernard Antoni Zonnenberg
  • Publication number: 20160279273
    Abstract: The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, the use of the microsphere, a method for detecting a tumour, and a therapeutic composition comprising the microsphere, the powder, or the suspension. The invention provides a method for preparing a microsphere that comprises a lanthanide metal phosphate complex, the method comprising: (a) providing an organic lanthanide metal complex microsphere, wherein the lanthanide metal is present in an amount of more than 20 wt.
    Type: Application
    Filed: March 31, 2016
    Publication date: September 29, 2016
    Inventors: Wouter Bult, Johannes Franciscus Wilhelmus Nijsen, Alfred Dirk van Het Schip
  • Patent number: 9334298
    Abstract: The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, the use of the microsphere, a method for detecting a tumor, and a therapeutic composition comprising the microsphere, the powder, or the suspension. The invention provides a method for preparing a microsphere that comprises a lanthanide metal phosphate complex, the method comprising: (a) providing an organic lanthanide metal complex microsphere, wherein the lanthanide metal is present in an amount of more than 20 wt.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: May 10, 2016
    Assignee: UMC Utrecht Hodling B.V.
    Inventors: Wouter Bult, Johannes Franciscus Wilhelmus Nijsen, Alfred Dirk van het Schip
  • Publication number: 20140227177
    Abstract: The invention provides a scanning suspension comprising a particle which is capable of at least in part disturbing a magnetic field, wherein said particle comprises a diameter of at least 1 ?m, and use thereof for obtaining a scanning image. Preferably, said particle comprises holmium and a composition capable of essentially maintaining its structure during irradiation. A particle of the invention is suitable for preparing a kit of parts, comprising a diagnostic and a therapeutic composition which both comprise particles of the invention with essentially the same chemical structure, wherein said therapeutic composition is more radioactive than said diagnostic composition. Said kit of parts is especially suitable for treatment of a tumor. First, the distribution of a particle of the invention within an individual can be determined with a scanning image obtained with said scanning composition.
    Type: Application
    Filed: December 17, 2013
    Publication date: August 14, 2014
    Applicants: Universiteit Utrecht Holding B.V., Universitair Medisch Centrum Utrecht
    Inventors: Johannes Franciscus Wilhelmus NIJSEN, Alfred Dirk VAN HET SCHIP, Bernard Antoni ZONNENBERG
  • Patent number: 8632751
    Abstract: The invention provides a scanning suspension comprising a particle which is capable of at least in part disturbing a magnetic field, wherein said particle comprises a diameter of at least 1 ?m, and use thereof for obtaining a scanning image. Preferably, said particle comprises holmium and a composition capable of essentially maintaining its structure during irradiation. A particle of the invention is suitable for preparing a kit of parts, comprising a diagnostic and a therapeutic composition which both comprise particles of the invention with essentially the same chemical structure, wherein said therapeutic composition is more radioactive than said diagnostic composition. Said kit of parts is especially suitable for treatment of a tumor. First, the distribution of a particle of the invention within an individual can be determined with a scanning image obtained with said scanning composition.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: January 21, 2014
    Assignees: Universitair Medisch Centrum Utrecht, Universiteit Utrecht Holding B.V.
    Inventors: Johannes Franciscus W. Nijsen, Alfred Dirk van het Schip, Bernard Antoni Zonnenberg
  • Patent number: 6373068
    Abstract: An irradiation vessel is made from such material and in such form that it can also be used as administration vessel of a medicine contained therein, this medicine first being irradiated with neutrons in a nuclear reactor and subsequently being administered as radioactive medicine to a patient without the medicine having to be moved outside the vessel intermediately. To prevent additional handling operations, with the risk of contamination of the medicine, higher radiation doses to personnel and radioactive contamination of the environment when vessels are used in which the irradiation and administration take place separately, a vessel has been developed which allows a medicine to be irradiated and to be directly administered to the patient thereafter via an external carrier liquid.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: April 16, 2002
    Assignee: Academisch Ziekenhuis Utrecht
    Inventors: Johannes Franciscus Wilhelmus Nijsen, Alfred Dirk van het Schip, Bernard Antoni Zonnenberg