Patents by Inventor Alfred Goldberg

Alfred Goldberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays for modulators of parkin activity using S5a as a parkin substrate
    Patent number: 7790365
    Abstract: The invention provides in vitro and cell-based assays for parkin activity, in which parkin-mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: September 7, 2010
    Assignee: Elan Pharma International Limited
    Inventors: Jennifer A. Johnston, Alfred Goldberg
  • Assays for Modulators of Parkin Activity Using Novel Substrates
    Publication number: 20080293089
    Abstract: The invention provides in vitro and cell-based assays for parkin activity, in which parkin-mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity.
    Type: Application
    Filed: January 31, 2008
    Publication date: November 27, 2008
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: Jennifer A. Johnston, Alfred Goldberg
  • Selective inhibition of proteasomes of tuberculosis and other bacteria
    Publication number: 20070093410
    Abstract: Compositions and methods for inhibiting bacterial proteasomes are provided. Methods of screening antibacterial compounds, methods of treating bacterial infections and disorders associated with bacterial infections, and methods of treating polyglutamine disorders are also provided.
    Type: Application
    Filed: August 25, 2006
    Publication date: April 26, 2007
    Applicant: President and Fellows of Harvard College
    Inventor: Alfred Goldberg
  • Methods and reagents related to foxo
    Publication number: 20060069049
    Abstract: The present invention relates to regulating the activity of Foxo and prevention and treatment of diseases associated with aberrant Foxo activity.
    Type: Application
    Filed: December 28, 2004
    Publication date: March 30, 2006
    Applicant: President and Fellows of Harvard College
    Inventors: Alfred Goldberg, Stewart Lecker, Marco Sandri
  • Transformation process for production of ultrahigh carbon steels and new alloys
    Patent number: 5445685
    Abstract: Ultrahigh carbon steels with superplastic properties are produced by heating a steel containing ferrite and carbide phases to a soaking temperature approximately 50.degree. C. above the A.sub.1 transformation temperature, soaking the steel above the A.sub.1 temperature for a sufficient time that the major portion of the carbides dissolve into the austenite matrix, and then cooling the steel in a controlled manner within predetermined limits of cooling rate or transformation temperature, to obtain a steel having substantially spheroidal carbides. New alloy compositions contain aluminum and solute additions which promote the formation of a fine grain size and improve the resistance of the carbides to coarsening at the forming temperature.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: August 29, 1995
    Assignee: The Regents of the University of California
    Inventors: Michael J. Strum, Alfred Goldberg, Oleg D. Sherby, Richard L. Landingham