Patents by Inventor Alfred Hedinger

Alfred Hedinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable crystal modifications of DOTAP chloride
    Patent number: 10000445
    Abstract: The present invention relates to crystal modifications of racemic (2R,S)- and enantiomerically pure (2R)-resp. (2S)-DOTAP chloride, to processes for the preparation thereof, and to the use thereof for the preparation of pharmaceutical compositions.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: June 19, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Michael Wilhelm Platscher, Alfred Hedinger
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 9586899
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: March 7, 2017
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Stable crystal modifications of DOTAP chloride
    Patent number: 9457087
    Abstract: The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (2S)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: October 4, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Michael Platscher, Alfred Hedinger
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20150336887
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: August 4, 2015
    Publication date: November 26, 2015
    Inventors: Bertrand M.C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 9115081
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: August 25, 2015
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • STABLE CRYSTAL MODIFICATIONS OF DOTAP CHLORIDE
    Publication number: 20140370081
    Abstract: The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (25)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Application
    Filed: September 2, 2014
    Publication date: December 18, 2014
    Applicant: Merck Patent GmbH
    Inventors: Michael Platscher, Alfred Hedinger
  • Stable crystal modifications of DOTAP chloride
    Patent number: 8853283
    Abstract: The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (2S)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: October 7, 2014
    Assignee: Merck Patent GmbH
    Inventors: Michael Platscher, Alfred Hedinger
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 8692002
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: April 8, 2014
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • STABLE CRYSTAL MODIFICATIONS OF DOTAP CHLORIDE
    Publication number: 20140093558
    Abstract: The present invention relates to crystal modifications of racemic (2R,S)- and enantiomerically pure (2R)-resp. (2S)-DOTAP chloride, to processes for the preparation thereof, and to the use thereof for the preparation of pharmaceutical compositions.
    Type: Application
    Filed: May 2, 2012
    Publication date: April 3, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Michael Wilhelm Platscher, Alfred Hedinger
  • Stable crystal modifications of DOPC
    Patent number: 8513446
    Abstract: The invention relates to stable crystal modifications of (R,S)-, (R)- and (S)-DOPC, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: August 20, 2013
    Assignee: Merck Patent GmbH
    Inventors: Michael Platscher, Alfred Hedinger
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20130102791
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 25, 2013
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • STABLE CRYSTAL MODIFICATIONS OF DOPC
    Publication number: 20110086091
    Abstract: The invention relates to stable crystal modifications of (R,S)-, (R)- and (5S)-DOPC, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Application
    Filed: May 13, 2009
    Publication date: April 14, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
    Inventors: Michael Platscher, Alfred Hedinger
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20100152464
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: November 18, 2005
    Publication date: June 17, 2010
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Stable Crystal Modifications of Dotap Chloride
    Publication number: 20080014254
    Abstract: The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (2S)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Application
    Filed: November 7, 2005
    Publication date: January 17, 2008
    Inventors: Michael Platscher, Alfred Hedinger
  • Process for the simultaneous production of fructose and gluconic acid from glucose-fructose mixtures
    Patent number: 4242145
    Abstract: A process for the simultaneous production of fructose and of gluconic acid from glucose-fructose mixtures and/or from invert sugar by the selective oxidation of the glucose proportion, wherein oxygen and/or air, activated by noble metal catalysts, are utilized as the oxidizing agents; the oxidation is conducted in a pH range of about 8 to 10; and the oxidation is terminated after the formation of 1 equivalent of carboxylic acid per mole of glucose employed.The thus-obtained gluconic acid can subsequently be separated from the unchanged fructose in a simple way and practically quantitatively, and can be isolated as the salt.
    Type: Grant
    Filed: February 21, 1979
    Date of Patent: December 30, 1980
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Rudolf Muller, Werner Kundig, Alfred Hedinger
  • Method of preparing 4-methyl-5-hydroxymethyl-imidazole
    Patent number: 4189591
    Abstract: The yield of 4-methyl-5-hydroxymethyl-imidazole from the known reaction between formaldehyde and 4-methyl-imidazole can be increased greatly if the reaction is performed in a concentrated aqueous medium at pH 11-13.5, preferably 12-13.5, at a temperature of 20.degree.-60.degree. C., preferably 30.degree.-40.degree. C., with an amount of formaldehyde not exceeding 1.5 mole per mole of 4-methyl-imidazole.
    Type: Grant
    Filed: January 25, 1979
    Date of Patent: February 19, 1980
    Assignee: Eprova Aktiengesellschaft
    Inventors: Hans-Rudolf Mueller, Werner Kuendig, Alfred Hedinger