Patents by Inventor Alfred J. Eglington

Alfred J. Eglington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .beta.-Lactam antibacterial agents, a process for the preparation and use in pharmaceutical compositions
    Patent number: 4444783
    Abstract: The compounds of the formulaes (IV), (V) and (VI): ##STR1## and salts and esters thereof where X is a bromine or chlorine atom, and n is 0 or 1; are antibacterial agents. Their preparation and use is described.
    Type: Grant
    Filed: October 1, 1981
    Date of Patent: April 24, 1984
    Assignee: Beecham Group Limited
    Inventor: Alfred J. Eglington
  • .beta.-Lactam antibiotics, their preparation and use
    Patent number: 4413000
    Abstract: The present invention provides the compounds of the formula (II): ##STR1## and salts and esters thereof wherein R.sup.3 is a hydrogen atom or is an organic bonded via a carbon atom to the carbapenem ring, n is zero or one, X is a saturated or unsaturated hydrocarbon radical optionally substituted by bromo or chloro, and R.sup.4 is a C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-10 aralkyl or aryl group, any of such groups R.sup.4 being optionally substituted. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: July 8, 1981
    Date of Patent: November 1, 1983
    Assignee: Beecham Group Limited
    Inventor: Alfred J. Eglington
  • .beta.-Lactam antibiotics, their preparation and their use in pharmaceutical compositions
    Patent number: 4387051
    Abstract: The present invention provides the compounds of the formula (II): ##STR1## and pharmaceutically acceptable salts and esters thereof wherein R.sup.3 is a hydrogen atom, a group HO.sub.3 S-- or a group R.sup.5 CO wherein R.sup.5 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, aryl, aryl(C.sub.1-6)alkyl or aryloxy(C.sub.1-6)alkyl; and R.sup.4 is an organic group other than methyl bonded to the --CO--NH-- moiety via a carbon atom; with the proviso that when R.sup.3 is a hydrogen atom or a group R.sup.5 CO the stereochemical configuration at the .alpha.-carbon atom of the C-6 substituent is S, and with the further proviso that when R.sup.3 is a group HO.sub.3 S-- the hydrogen atoms at C-5 and C-6 are cis. Their use is described as are processes for their preparation. Compounds wherein the R.sup.4 CO-- moiety is replaced by a hydrogen atom are also prepared.
    Type: Grant
    Filed: October 28, 1980
    Date of Patent: June 7, 1983
    Assignee: Beecham Group Limited
    Inventors: David F. Corbett, Robert Southgate, Alfred J. Eglington
  • Carbapenum derivatives, a process for their preparation and their use in pharmaceutical compositions and intermediates
    Patent number: 4278686
    Abstract: The present invention provides antibiotic compounds of the formula: ##STR1## and salts and cleavable esters thereof wherein X is a SCH.sub.2 CH.sub.2 NH.sub.2 or YNH-COCH.sub.3 group where Y is a SCH.sub.2 CH.sub.2, trans --SO--CH.dbd.-- or cis or trans --S--CH.dbd.CH-- group and R is a lower alkyl, aryl, aralkyl, lower alkenyl, or substituted lower alkyl.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: July 14, 1981
    Assignee: Beecham Group Limited
    Inventors: David F. Corbett, Alfred J. Eglington
  • Side chain sulphoxide metabolites
    Patent number: 4210662
    Abstract: Compounds of the formula ##STR1## and salts thereof are useful both for their antibacterial activity and as synergists in combination with penicillins and cephalosporins.
    Type: Grant
    Filed: May 25, 1977
    Date of Patent: July 1, 1980
    Assignee: Beecham Group Limited
    Inventors: Alfred J. Eglington, Thomas T. Howarth, David F. Corbett