Patents by Inventor Alfred Jentzko

Alfred Jentzko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor
    Patent number: 8263352
    Abstract: The present invention concerns a method of detecting hepcidin, prohepcidin or fragments thereof, by contacting the sample with an antibody or fragment thereof that specifically binds to one or more epitopes contained within amino acids 28-47 of SEQ ID NO:2.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: September 11, 2012
    Assignee: DRG International, Inc.
    Inventors: Hasan Kulaksiz, Cyril E. Geacintov, Alfred Jentzko, Wolfgang Stremmel
  • Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor
    Patent number: 8017737
    Abstract: The present invention concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the amino acid sequence between and including amino acids 60 and 84, or, in another embodiment, amino acids 74 and 81, as aligned with the human pre-pro-hepcidin precursor protein, and quantifying the pro-hepcidin and/or mature hepcidin level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of prohepcidin/mature hepcidin is indicative of the disease condition.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 13, 2011
    Inventors: Hasan Kulaksiz, Cyril E. Geacintov, Alfred Jentzko
  • Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor
    Publication number: 20070224186
    Abstract: The present invention concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the amino acid sequence between and including amino acids 60 and 84, or, in another embodiment, amino acids 74 and 81, as aligned with the human pre-pro-hepcidin precursor protein, and quantifying the pro-hepcidin and/or mature hepcidin level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of prohepcidin/mature hepcidin is indicative of the disease condition.
    Type: Application
    Filed: January 25, 2007
    Publication date: September 27, 2007
    Inventors: Hasan Kulaksiz, Cyril Geacintov, Alfred Jentzko