Patents by Inventor Alfred Jonczyk

Alfred Jonczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclopeptides of the formula I
    Patent number: 5693612
    Abstract: The invention relates to novel cyclopeptides of the formula Icyclo-(Arg-A-Asp-R.sup.1 -R.sup.2) Iin whichA, R.sup.1 and R.sup.2 have the meaning given in claim 1, and their salts.These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation, bones and in tumour therapy, and as antimicrobial and antiviral active compounds.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: December 2, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Alfred Jonczyk, Gunter Holzemann, Simon Goodman, Horst Kessler, Roland Haubner, Jochen Wermuth
  • Peptide and renin inhibitors
    Patent number: 5215966
    Abstract: Novel amino acid derivatives of the formula IX--Z--NH--CHR.sup.1 --CO--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--W'--Ywherein X, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, W', Y and n have the meanings defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: June 1, 1993
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Gunter Holzemann, Peter Raddatz, Claus J. Schmitges, Klaus Otto Minck, Alfred Jonczyk, Johannes Sombroek, Joachim Gante
  • Peptides possessing renin inhibitory activity
    Patent number: 4812555
    Abstract: New peptides of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CHOH--(CHR.sup.4).sub.n --CO--Ewherein X, Z, R.sup.2, R.sup.3, R.sup.4, E and n are as defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: March 14, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus O. Minck
  • Statine-containing peptides useful in medicaments
    Patent number: 4755592
    Abstract: New peptides of the formula IX--Z--W--E--W'--Y Iwherein X, Z, W, E, W' and Y are as defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: July 5, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus-Otto Minck, Hans-Eckart Radunz, Johannes Sombroek
  • Peptides useful for inhibition of renin
    Patent number: 4709010
    Abstract: New peptides of the formula IX--Z--NH--CHR--CHOH--CH.sub.2 --CO--NH--CHR.sup.1 --CH.sub.2 --NH--CHY--C.sub.n H.sub.2n --R.sup.2 Iin whichX is H, R.sup.3 --O--CH.sub.2 --CO--, R.sup.3 --O--CO--, R.sup.3 --CH.sub.2 --O--CO-- or R.sup.3 --C.sub.m H.sub.2m --CO--,Z is 1 to 4 aminoacid residues which are bonded together in the manner of peptides and are selected from the group comprising Abu, Ala, Arg, Asn, Dab, Gln, Gly, His, Ile, Leu, Lys, Met, NLeu, Orn, Phe, Pro, Trp, Tyr and Val,is A, Ar-alkyl (in which the group -alkyl contains 1-4 C atoms) or cycloalkyl-alkyl having 4-11 C atoms,R.sup.1 is H or A,Y is H, A, --C.sub.p H.sub.2p --OR.sup.4, --C.sub.p H.sub.2p --NHR.sup.4, --COOR.sup.4, --CONHR.sup.4 or --CONA.sub.2,R.sup.2 is A, cycloalkyl having 3-7 C atoms, Ar, pyridyl, indolyl, imidazolyl, piperidyl, N-benzylpiperidyl or piperazinyl,R.sup.3 is A, cycloalkyl having 3-7 C atoms or Ar,R.sup.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: November 24, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Gunter Holzemann, Peter Raddatz, Alfred Jonczyk, Claus J. Schmitges