Abstract: The present invention relates to a multi-layered, physiologically tolerated oral dosage form for pharmaceutically active compounds. The dosage form comprises a central core, a middle layer, and an outer shell, at least one of which includes at least one pharmaceutically active substance. By varying the diameter of the core, a different middle layer volume is obtained within a fixed outer shell dimension. This gives the ability to obtain different dosage strengths for one composition without the need of reformulation work. The oral dosage form is produced in a single-step, continuous process by coating the core with the middle layer and the outer shell.

Abstract: The present invention relates to a multi-layered, physiologically tolerated oral dosage form for pharmaceutically active compounds. The dosage form comprises a central core, a middle layer, and an outer shell, at least one of which includes at least one pharmaceutically active substance. By varying the diameter of the core, a different middle layer volume is obtained within a fixed outer shell dimension. This gives the ability to obtain different dosage strengths for one composition without the need of reformulation work. The oral dosage form is produced in a single-step, continuous process by coating the core with the middle layer and the outer shell.

Abstract: A tissue fastening device comprising (a) a fastener member having a pair of legs extending from the same side of a connecting cross piece, said fastener member adapted to be placed on one side of the tissue to be joined with the legs penetrating the tissue, said fastener member being an oriented crystalline polymeric material, whereby the fastener member has sufficient inherent strength and stiffness so said legs can penetrate the tissue to be fastened, and (b) a receiver member to secure said fastener member in place. The fastener member is formed by forming an oriented polymeric filament into the configuration of the fastener member, and annealing the filament while in such configuration while it is being restrained so as to prevent shrinkage.

Abstract: A tissue fastening device comprising (a) a fastener member having a pair of legs extending from the same side of a connecting cross piece, said fastener member adapted to be placed on one side of the tissue to be joined with the legs penetrating the tissue, said fastener member being an oriented cystalline polymeric material, whereby the fastener member has sufficient inherent strength and stiffness so said legs can penetrate the tissue to be fastened, and (b) a receiver member to secure said fastener member in place.

Abstract: A wound closure tape of a substrate and a pressure sensitive adhesive. The substrate has a specific pattern of indentations which provide the tape with improved elastic properties, excellent drape and desired abrasion and tensile properties.