Patents by Inventor Alfred P. Wolf
Alfred P. Wolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5254726Abstract: A method for synthesizing no-carrier-added (NCA) aryl [.sup.18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro aldehydes having a suitably protected hydroxyl substitutent on an electron rich ring. The reaction isThe U.S. Government has rights in this invention pursuant to Contract Number DE-AC02-76CH00016, between the U.S. Department of Energy and Associated Universities Inc.Type: GrantFiled: June 7, 1991Date of Patent: October 19, 1993Assignee: The United States of America as represented by the Department of EnergyInventors: Yu-Shin Ding, Joanna S. Fowler, Alfred P. Wolf
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Patent number: 4913891Abstract: This invention involves a new strategy for imaging and mapping enzyme activity in the living human and animal body using positron emitter-labeled suicide enzyme inactivators or inhibitors which become covalently bound to the enzyme as a result of enzymatic catalysis. Two such suicide inactivators for monoamine oxidase have been labeled with carbon-11 and used to map the enzyme subtypes in the living human and animal body using PET. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography.Type: GrantFiled: May 22, 1987Date of Patent: April 3, 1990Assignee: The United States of America as represented by the United States Department of EnergyInventors: Joanna S. Fowler, Robert R. MacGregor, Alfred P. Wolf, Bengt Langstrom
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Patent number: 4874600Abstract: The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.Type: GrantFiled: April 17, 1986Date of Patent: October 17, 1989Assignee: The United States of America as Represented by the United States Department of EnergyInventors: Daniel W. McPherson, Joanna S. Fowler, Alfred P. Wolf
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Patent number: 4871527Abstract: There is disclosed radioligands labeled with the position emitting radionuclide [.sup.18 F] suitable for dynamic study in living humans with position emission transaxial tomography. These new [.sup.18 F]-N-fluoroalkylspiroperidols, wherein the alkyl group contains from 2-6 carbon atoms, exhibit extremely high affinity for the dopamine receptors and provide enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to make these new radioligands useful for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for these radioligands as well as a new procedure for preparing the radiolabeled alkyl halide alkylating reagents are also disclosed.Type: GrantFiled: April 29, 1987Date of Patent: October 3, 1989Assignee: The United States of America as represented by the United States Department of EnergyInventors: Chyng-Yann Shiue, Alfred P. Wolf, Lan-Qin Bai, Ren-Tui Teng
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Patent number: 4617386Abstract: Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound in which methyl 4,6-O-benzylidine-3-O-methyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopy ranoside is reacted with a triflating reagent, the resulting compound reacted with CsHF.sub.2, RbF or the corresponding .sup.18 F-compounds, and thereafter the alkyl groups removed by hydrolysis.Type: GrantFiled: April 25, 1983Date of Patent: October 14, 1986Assignee: The United States of America as represented by the United States Department of EnergyInventors: David R. Elmaleh, Shlomo Levy, Chyng-Yann Shiue, Alfred P. Wolf
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Patent number: 4439414Abstract: The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.Type: GrantFiled: January 26, 1982Date of Patent: March 27, 1984Assignee: The United States of America as represented by the United States Department of EnergyInventors: Chyng-Yann Shiue, Alfred P. Wolf
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Patent number: 4436717Abstract: The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.Type: GrantFiled: May 29, 1981Date of Patent: March 13, 1984Assignee: The United States of America as represented by the United States Department of EnergyInventors: Chyng-Yann Shiue, Alfred P. Wolf
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Patent number: 4252668Abstract: A solution of potassium-38 suitable for use as a radiopharmaceutical and a method for its production. Argon is irradiated with protons having energies above the threshold for the .sup.40 Ar(p,3n).sup.38 K reaction. The resulting potassium-38 is dissolved in a sterile water and any contaminating chlorine-38 is removed.Type: GrantFiled: February 22, 1979Date of Patent: February 24, 1981Assignee: The United States of America as represented by the United States Department of EnergyInventors: Richard M. Lambrecht, Alfred P. Wolf
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Patent number: 4162142Abstract: An improved process for labeling organic compounds with tritium is carried out by depositing the selected compound on the extensive surface of a porous structure such as a membrane filter and exposing the membrane containing the compound to tritium gas activated by the microwave discharge technique. The labeled compound is then recovered from the porous structure.Type: GrantFiled: June 29, 1978Date of Patent: July 24, 1979Assignee: The United States of America as represented by the United States Department of EnergyInventors: Richard L. E. Ehrenkaufer, Alfred P. Wolf, Wylie C. Hembree
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Patent number: 4106982Abstract: A method of synthesizing H.sup.11 CN involving the proton irradiation of N.sub.2 + H.sub.2 to produce a mixture of .sup.11 CH.sub.4 and NH.sub.3 followed by the reaction of .sup.11 CH.sub.4 and NH.sub.3 to produce H.sup.11 CN and the separation of carrier free H.sup.11 CN.Type: GrantFiled: April 1, 1974Date of Patent: August 15, 1978Assignee: The United States of America as represented by the United States Department of EnergyInventors: David R. Christman, Ronald D. Finn, Alfred P. Wolf
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Patent number: 4011307Abstract: .sup.203 Pb-tris complex injected for use in the detection and localization of tumors. The lead-203 is produced from the deuteron bombardment of a thallium target and chemically separated from the thallium. The tris is added which complexes with the lead-203.Type: GrantFiled: June 3, 1976Date of Patent: March 8, 1977Assignee: The United States of America as represented by the United States Energy Research and Development AdministrationInventors: Richard M. Lambrecht, Samuel Packer, Jerald C. Merrill, Harold L. Atkins, Alfred P. Wolf, Patrick R. Bradley-Moore
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Patent number: 3959455Abstract: The method of labeling indocyanine green (ICG) with carrier-free iodine-123 comprising the steps of condensing xenon-123 on crystals of ICG followed by permitting decay of the .sup.123 Xe a sufficient length of time to produce .sup.123 I-electronically excited ions and atoms which subsequently label ICG.Type: GrantFiled: July 1, 1975Date of Patent: May 25, 1976Assignee: The United States of America as represented by the United States Energy Research and Development AdministrationInventors: Azizullah N. Ansari, Richard M. Lambrecht, Carol S. Redvanly, Alfred P. Wolf
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Patent number: H74Abstract: Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound by the reaction of acetyl hypofluorite or the corresponding .sup.18 F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.Type: GrantFiled: February 24, 1983Date of Patent: June 3, 1986Assignee: The United States of America as represented by The United States Department of EnergyInventors: Chyng-Yann Shiue, Piero A. Salvadori, Alfred P. Wolf, Joanna S. Fowler, Robert R. MacGregor
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Patent number: H1209Abstract: There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.Type: GrantFiled: October 4, 1985Date of Patent: July 6, 1993Assignee: The United States of America as represented by the United States Department of EnergyInventors: Chyng-Yann Shiue, Joanna S. Fowler, Alfred P. Wolf