Patents by Inventor Alfred Poulos

Alfred Poulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified polyunsaturated fatty acids
    Patent number: 6376688
    Abstract: The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two substitutions selected from the group consisting of &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia. It is also preferred that the polyunsaturated fatty acid compound includes a further substitution selected from the group consisting of hydroxy, hydroperoxy, peroxy, carboxymethyl substitutions or attached to an amino acid.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: April 23, 2002
    Assignee: Peptide Technology Limited
    Inventors: Antonio Ferrante, Alfred Poulos, Christopher John Easton, Michael Joseph Pitt, Thomas Alistair Robertson, Deborah Ann Rathjen
  • Methods of treating immunopathologies using polyunsaturated fatty acids
    Patent number: 6262119
    Abstract: Method of treating or ameliorating symptoms of T-cell mediated disease wherein a composition comprising a therapeutically effective amount of a polyunsaturated fatty acid and a pharmaceutically acceptable carrier is administered to the patient. The polyunsaturated fatty acid contains 18-25 carbon atoms, 1-6 double bonds and has 1 or 2 substitutions selected from &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia, based on the fatty acid acyl carbon atom, or the polyunsaturated fatty acid contains 16-26 carbon atoms, 3-double bonds and is covalently coupled at the carboxylic acid group to an amino acid.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: July 17, 2001
    Assignees: Peptide Technology Limited, Women's and Children's Hospital Adelaide
    Inventors: Antonio Ferrante, Alfred Poulos, Michael Joseph Pitt, Christopher John Easton, Merilyn Joy Sleigh, Deborah Ann Rathjen, Fred Widmer
  • Synthetic polyunsaturated fatty acid analogues
    Patent number: 5998476
    Abstract: The invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity, or anti-inflammatory activity. The polyunsaturated fatty acids contain a 16-26 carbon chain, 3-6 double bonds and are covalently coupled at the carboxylic acid group to an amino acid. It is preferred that the fatty acid contains 18-22 carbons and that the amino acid is glycine or aspartic acid. Preferred compounds are .gamma.-linolenic acid-glycine, .alpha.-linolenic acid-glycine, arachidonic acid-aspartic acid, eicosapentaenoic acid-aspartic acid and docosahexaenoic acid-aspartic acid.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: December 7, 1999
    Assignee: Peptide Technology Limited
    Inventors: Merilyn Joy Sleigh, Fred Widmer, Paul Adam Schober, Antonio Ferrante, Alfred Poulos, Deborah Ann Rathjen
  • Polyunsaturated fatty acids and uses thereof
    Patent number: 5767156
    Abstract: The present invention provides a method of stimulating macrophage, neutrophil and/or monocyte function in a subject. The method involves the administration of an effective amount of a free fatty acid having a 18-24 carbon chain length with 2-6 double bonds. Preferred polyunsaturated fatty acids are 20:4(n-6), 20:3(n-6), 20:5(n-3), 22:6(n-3), 19:2(n-6), 18:3.gamma.(n-6), 23:4(n-6) and 24:4(n-6).
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: June 16, 1998
    Assignees: Peptide Technology Limited, Women's and Childrens Hospital Adelaide
    Inventors: Antonio Ferrante, Alfred Poulos, Deborah A. Rathjen
  • Methods for treating malaria and other diseases
    Patent number: 5604258
    Abstract: Methods for treating melanoma or a disease caused by bacteria, fungi, Chlamydia, Mycoplasma, Rickettsia or Plasmodium falciparum are disclosed wherein a fatty acid having a carbon length up to 30 carbon atoms and two or more double and/or triple bonds, derivatives or oxidation products thereof is administered.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: February 18, 1997
    Assignee: Women's and Children's Hospital Adelaide
    Inventors: Antonio Ferrante, Alfred Poulos, Lakshmi M. Kumaratilake, Brenton S. Robinson