Patents by Inventor Alfred Steinberg
Alfred Steinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080031936Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: November 10, 2006Publication date: February 7, 2008Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., U.S.A., as represented by the Secretary, Dept. of Health and Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20070202128Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: December 22, 2006Publication date: August 30, 2007Applicants: Coley Pharmaceutical Group, Inc, United States of America as represented by the Secretary, Department of Health & Human Services, University of Iowa Research FoundationInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20070066553Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: August 11, 2006Publication date: March 22, 2007Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20070009482Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: May 11, 2005Publication date: January 11, 2007Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20070010470Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: May 11, 2005Publication date: January 11, 2007Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20060094683Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: December 7, 2005Publication date: May 4, 2006Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., USA, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20060089326Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: December 7, 2005Publication date: April 27, 2006Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20060058251Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.Type: ApplicationFiled: March 6, 2003Publication date: March 16, 2006Applicants: University of Iowa Research Foundation, The US, as Represented by the Secretary, Department of Health and Human Services, Coley Pharmaceutical Group, Inc.Inventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20060003955Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: February 25, 2005Publication date: January 5, 2006Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary Department of Health & Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20050277609Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: January 7, 2005Publication date: December 15, 2005Applicants: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The USA, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20050277604Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: May 9, 2003Publication date: December 15, 2005Applicants: University of Iowa Research Foundation, The U.S.A., as represented by the Secretary, Department of Health and Human Services, Coley Pharmaceutical Group, Inc.Inventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20050244380Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: May 11, 2005Publication date: November 3, 2005Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20050244379Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: May 11, 2005Publication date: November 3, 2005Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20050245477Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: May 11, 2005Publication date: November 3, 2005Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20050239732Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: October 1, 2004Publication date: October 27, 2005Inventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20050239736Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: February 25, 2005Publication date: October 27, 2005Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20050233995Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: April 23, 2004Publication date: October 20, 2005Applicants: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20050233999Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: October 1, 2004Publication date: October 20, 2005Inventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20050215500Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: October 22, 2004Publication date: September 29, 2005Applicants: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Dept. of Health & Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20050171047Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: January 14, 2005Publication date: August 4, 2005Applicants: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The USA, as represented by the Secretary, Dept. of Health & Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg