Abstract: A system automatically calculates drug infusion applicable to a patient to induce a satisfactory anesthetic state during surgery. The automatic calculation system would be determined by target values of physiological monitors to evaluate the patient's condition. Automatic infusion increases patient safety, reducing post-surgical morbidity and mortality, and reduces continuous decision-making by the specialist. An electronic system implements a MIMO-PID controller that calculates the infusion of various drugs on the basis of a control error defined by deviations in the patient's condition, which is analyzed by several monitors. The automatic drug infusions are determined by safety systems for preventing under and/or over infusion events and are complemented with correction and feedback systems.