Patents by Inventor Alfredo Brana

Alfredo Brana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid glycosylated products and their production and use
    Publication number: 20070059689
    Abstract: Hybrid glycosylated products such as polyketides and peptides are produced by transforming a host cell with (a) a gene cassette for synthesising an activated sugar and (b) nucleic acid encoding a glycosyltransferase (GT). The cell also produces or is supplied with an aglycone template. At least some of the components (sugar, aglycone, GT, sugar synthesis genes, cells) are mutually heterologous.
    Type: Application
    Filed: November 29, 2002
    Publication date: March 15, 2007
    Inventors: Ignacio Aguirrezabalaga, Nerea Allende, Alfredo Brana, Carmen Mendez, Leticia Rodriquez, Jose Salas
  • Derivatives of mithramycin and methods of making and uses thereof
    Publication number: 20050192432
    Abstract: The invention, in one aspect, generally relates to mithramycin derivatives from mutated Streptomyces argillaceous and their production. The invention also relates using the derivatives for the treatment of various diseases. Finally, the invention relates to a mutated Streptomyces argillaceous useful in the production of the mithramycin derivatives.
    Type: Application
    Filed: March 10, 2004
    Publication date: September 1, 2005
    Inventors: Jurgen Rohr, Lily Remsing, Mohammad Nur-e-Alam, Jose Salas, Carmen Mendez, Alfredo Brana, Ana Gonzalez
  • Gene cluster for thienamycin biosynthesis, genetic manipulation and utility
    Publication number: 20040038250
    Abstract: Isolation, cloning and sequencing of the cluster of genes involved in the biosynthesis of the carbapenem thienamycin by streptomyces cattleya, and the use of those genes to increase thienamycin production, and/or related antibiotics, in the producing strains, and obtaining new derivatives by means of genetic manipulation which implies gene expression, mutagenesis by gene replacement and combinatorial biosynthesis.
    Type: Application
    Filed: February 26, 2003
    Publication date: February 26, 2004
    Applicants: ASTUR-PHARMA, S.A., UNIVERSIDAD DE OVIEDO
    Inventors: Luz Elena Nunez, Gloria Blanco, Alfredo Brana, Carmen Mendez, Jose Antonio Salas